Conserved Protein Domain Family
murD

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TIGR01087: murD 
UDP-N-acetylmuramoylalanine--D-glutamate ligase
[Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Statistics
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PSSM-Id: 273436
Aligned: 16 rows
Threshold Bit Score: 411.734
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O83873        12 TVTIMGLGVHGGgcAAACFCAEAGARLTVTDLRNADALTPSLKRLRAYP-SIR-FTLgEHrLEDFENAHVVIKNPIVKgA 89  Treponema palli...
AAF95546      36 HVVVVGLGITGL--SVVNYLRKYHPSVTVQVIDTREAP---PGQEQLSSdVAL-HRSgWN-LEWLLNADLVVTNPGIAlA 108 Vibrio cholerae...
Q9ZDC2         8 KIGIFGLGKTGI--SVYEELKNKYDLIVYDDLEAN--RDIFKELFGNNLiTVL-SDS------RWQDLDKIVLSPGVPlT 76  Rickettsia prow...
CAB74268       2 KISLFGYGKTTR--AIAENLVDKFGPFDIYDDHFTETKKDTLGNLLLNP---------ND--FDDNLSDIEIPSPGFPpK 68  Campylobacter j...
WP_004082930   2 KIGFLGFGKSNR--SLLKYLLNHQEAKFFVSEAKTLDGETKKFLEEHSVeYE---EG-GH-TEKLLDCDVVYVSPGIKpD 74  Thermotoga mari...
WP_010881357   2 KFLVWGLGRSGK--GALKLLKERGFEVYAGDDSQNPELWR----------------------EVLGEVDTVVLSPGIPpS 57  Aquifex aeolicus
WP_002224926   7 KILVAGLGGTGI--SMIAYLRKNGAEVAAYD--AELKPERVSQIGKMFDgLVfytGR-LK-DALDNGFDILALSPGISeR 80  Neisseria menin...
WP_009872138   5 RVVVIGLGVSGR--SIAHFLAQKGVCVLGVDKSLHALQNCPYIQEKYLE----------N-EEFPSQVDYVVRSPGVSkE 71  Chlamydia trach...
WP_014518191   4 RILILGTGITGK--SVARFLYQQGHYLIGADNSLESLISVDHLHDRLLMgAS----------EFPENVDLVIRSPGIKpY 71  Chlamydia pneum...
WP_000703484   2 KISLLGHGKTTL--ALGRFFKKNHNEVKFFDDKFLSSFKDSEGFLCYPS----------K-DFNPNDSQLEIVSPGISfT 68  Helicobacter py...
O83873        90 HNIYLSAAQragaRIETDISLFLR---LS---P----APLLAVSGSKGKSSTASALCYSLRALGFPAFLGGNSTVSPLEF 159 Treponema palli...
AAF95546     109 TPEIQQVLAag-iPVVGDIELFAW---HVdt-------pVIAITGSNGKSTVTDLSGVLANAAGVKAAVGGNIGVPALDL 177 Vibrio cholerae...
Q9ZDC2        77 HEVVRIAHHfn-iPIISDIDLFFE---KSk------nLKFIAITGTNGKSTTTALISHILNSNGLDYPVAGNIGVPALQA 146 Rickettsia prow...
CAB74268      69 HKLIQKAKN-----LQSEYDFFYD---IM--------PKSVWISGTNGKTTTTQMATHLLSHIG--AVMGGNVGT-PLAE 129 Campylobacter j...
WP_004082930  75 TSMIELLSSrg-vKLSTELQFFLD---NVd--P----KKVVGITGTDGKSTATALMYHVLSGRGFKTFLGGNFGTPAVEA 144 Thermotoga mari...
WP_010881357  58 HPLWKEALKke-kEVVGELELAYR---FF---K----GKVIAITGTDGKSTTTRLTYLILKKFFDEVFEAGNIGKPFSEV 126 Aquifex aeolicus
WP_002224926  81 QPDIEAFKQng-gRVLGDIELLAD---IVnrrD----DKVIAITGSNGKTTVTSLVGYLCIKCGLDTVIAGNIGTPVLEA 152 Neisseria menin...
WP_009872138  72 HPWVQAAIAsh-iPVMADIQLAFQtekFT---E----RESLAITGTTGKTTTILFLEYLFKRSGIPAFAMGNVGIPILDG 143 Chlamydia trach...
WP_014518191  72 HPWVEQAVSlk-iPVVTDIQVALK---TP---Efq-rYPSFGITGSNGKTTTTLFLTHLLNTLGIPAIAMGNIGLPILDH 143 Chlamydia pneum...
WP_000703484  69 HPLVIKAKH-----LVSEYDYINS---LF---DlvftPTIISISGTNGKTTTTEMLTMLLED--FKAVSGGNIGTP-LIE 134 Helicobacter py...
O83873       160 VRHt--TPATPVVLELSSWQLADLRAVDaqdhtvhhagllrP--EIAIMTPIMADHQNWYADMESYVADKQVLYAHQGTH 235 Treponema palli...
AAF95546     178 IS----PDVELYVLELSSFQLETTSSLK-------------L--KAAAFLNLSEDHMDRYQGMEDYRQAKLRIFDHAe-- 236 Vibrio cholerae...
Q9ZDC2       147 KASn--EG---YVLELSSFQLDLVKSFT-------------V--KVAVLLNITPDHLDRYQDMNDYIAAKAKIFDRMDKD 206 Rickettsia prow...
CAB74268     130 LN----PYAKLWILETSSFTLHYTHKAK-------------P--EIYALLPISPDHLSWHGSFDNYVQDKLSVLKRMNEC 190 Campylobacter j...
WP_004082930 145 LEG---E-YDYYVLEMSSFQLFWSERPY-------------L--SNFLVLNISEDHLDWHSSFKEYVDSKLKPAFLQTEG 205 Thermotoga mari...
WP_010881357 127 VLE---NPEGIAVLEVSSFQGKTLKTFR-------------P--NIGAFISFSVDHLDWHPSIEDYLKSKYRIFENQTEE 188 Aquifex aeolicus
WP_002224926 153 EWQregKKADVWVLELSSFQLENTESLR-------------P--TAATVLNISEDHLDRYDDLLDYAHTKAKIFRG---D 214 Neisseria menin...
WP_009872138 144 M-----QNPGVRIVEISSFQLADQEKSY-------------PvlSGGMILNISDNHLDYHGNFSEYFQAKQNLALCMRNP 205 Chlamydia trach...
WP_014518191 144 MGQ---PG--VRVVEISSFQLATQEEHI-------------PalSGSVFLNFSRNHLDYHRNLDAYFDAKLRIQKCLRQD 205 Chlamydia pneum...
WP_000703484 135 LFE---KRSPLWVLETSSFSLHYTNKAY-------------P--LIYLLINIEADHLTWHCNFENYLNAKLKVLTLMPKT 196 Helicobacter py...
O83873       236 dtLLCN---ADdg-wGPRFAceAQKNGVRVFWYTAQSpetacractprLMERALWRATDGTYWARFAegdracmlippql 311 Treponema palli...
AAF95546     237 -tAVVN---AD-----DTQTfpDHAAHLQVVTFGVEQ-----------AAQFSLAQHQGREYLFARDeav--------ma 288 Vibrio cholerae...
Q9ZDC2       207 syAVIN---IDndycRKIFVllQKDQSIKLIPFSVTK-----------ILKNGISIVDDK--IHDNDlty--------kl 262 Rickettsia prow...
CAB74268     191 dvVILP---KIya-nTP--------TKAHKISYEDEK-----------DLAVKFGIDTEKISFKS--------------- 232 Campylobacter j...
WP_004082930 206 dlFVYN---KH----IERLRnlEGVRSRKIPFWTDENf----------ATEKELIVRGKKYTLPGN-------------- 254 Thermotoga mari...
WP_010881357 189 dfLILN---------DLVYEikKTPSRARKVLFSELY------------INSDSVFYKDIRLFNPKN------------- 234 Aquifex aeolicus
WP_002224926 215 gvQVLN---AD----D-AFCraMKRAGREVKWFSLEH-----------EADFWLERETGR--LKQGN------------- 260 Neisseria menin...
WP_009872138 206 ddLWVG---DE-------------RFYGHLYLEEVQK-----------YM----RLLDKESALKP--------------- 239 Chlamydia trach...
WP_014518191 206 ktFWVW---EE----C---------SLGNSYQIYSEE-----------I----EEILDKGDALKP--------------- 239 Chlamydia pneum...
WP_000703484 197 slAILPlkfKE----HPII----QNSQAQKIFFDKSE-----------EVLERLKIPSNALFFKGAF------------- 244 Helicobacter py...
O83873       312 hVP------GRVLQTQVASAALAALLFAQRHSL-PpsscppcfcahshspayanhasppdyacpsahspfqehTR-RLAQ 383 Treponema palli...
AAF95546     289 cAE------LSLVGRHNVANVLTVLALLDSAGV-N--------------------------------------FR-LALD 322 Vibrio cholerae...
Q9ZDC2       263 pLN------KNLQGLHNCENIAASYAVAKIIGL-E--------------------------------------SK-KILE 296 Rickettsia prow...
CAB74268     233 ---------PFLLDAIMALAIEKILLDTL---S---------------------------------------------YK 255 Campylobacter j...
WP_004082930 255 ------------YPYQMRENILAVSVLYMEMFN-E--------------------------------------LE-SFLE 282 Thermotoga mari...
WP_010881357 235 -L--------KIRGLHNVYNASVASLIALTLGL-K--------------------------------------PE-DFEE 265 Aquifex aeolicus
WP_002224926 261 -EDlivtqdIPLQGLHNAANVMAAVALCEAIGL-S--------------------------------------RE-ALLE 299 Neisseria menin...
WP_009872138 240 ------------LYLHDKYNYCCAYLLAKTEFP-I--------------------------------------SEtSFIE 268 Chlamydia trach...
WP_014518191 240 ------------IYLHDRDNYCAAYALANEVGWvS--------------------------------------PE-GFLK 268 Chlamydia pneum...
WP_000703484 245 -LL------DAAL----ALLVYEQFLKIKNLKW-Qd------------------------------------yRE-NALK 275 Helicobacter py...
O83873       384 ALESYTGIEHRLEFFYEKGGLRFYNDSASTVPEATIAALEAF-DES--VVLIVGGTDKNADYQPLAQAAAKAHALYLLAG 460 Treponema palli...
AAF95546     323 ALKSYTGLTHRCQVVADNHGIKWVNDSKATNVASTLAALSGL-KIEgqLYLLVGGVGKGADFTPLAPVLATLPVQLCCFG 401 Vibrio cholerae...
Q9ZDC2       297 SISSFQSLHHRMQYIGSINNISFYNDSKATNAISALQSIKAL-DN---IYWLAGGIPKEGGIEGIKPYFN-KIKKAYFYG 371 Rickettsia prow...
CAB74268     256 LLNSFVMEKNKLEELKDSQNRLWVNDTKATNESAVMAALSRY-KDKk-IHLIIGGDDKGVDLSNLFDFMKGFDIELYAIG 333 Campylobacter j...
WP_004082930 283 LLRDFKPLPHRMEYLGQIDGRHFYNDSKATSTHAVLGALSNF-DK---VVLIMCGIGKKENYSLFVEKASPKLKHLIMFG 358 Thermotoga mari...
WP_010881357 266 VIYEFRGLPHRLEFLGNFNGVEVYNDSKSTTPHALMHALKTFpDNS--VILIVGGKDKGADFYSLRHIVQKKVKIALAIG 343 Aquifex aeolicus
WP_002224926 300 HVKTFQGLPHRVEKIGEKNGVVFIDDSKGTNVGATAAAIAGL-QNP--LFVILGGMGKGQDFTPLRDALVGKAKGVFLIG 376 Neisseria menin...
WP_009872138 269 AVATFNKPPHRMEYLGQKQGIHYINDSKATTVSATETALLGV-GNQ--AIVILGGRNKGCTFSSLLPALRKAAKSVVAMG 345 Chlamydia trach...
WP_014518191 269 AIRTFEKPAHRLEYLGEKDGVHYINDSKATTVTAVEKALMAV-GKD--VIVILGGKDKGGDFPALASVLSQTTKHVIAMG 345 Chlamydia pneum...
WP_000703484 276 RLNAFKIGSHKMEEFRDKQGRLWVDDSKATNIDATLQALKTF-KNQk-IHLILGGDIKGVNLTPLFEEFKNYKISLYAIG 353 Helicobacter py...
O83873       461 SATARLQPLLHAAQVPFYg--PFTSLEVLLQDLRARQKSPGVIVFSPGAASFELFAHEFERGTTFKSQVRI 529 Treponema pallidum subsp...
AAF95546     402 VDGHQFMPLHPSARF-------YDSMESIIRSIRPQLKSGDMVLLSPACASFDQFKNFMARGDIFAQLARQ 465 Vibrio cholerae O1 biova...
Q9ZDC2       372 QAKAMFANTAKNIIDFVIcdnLEYAFNIAYKDAVSDTTEVKNILLAPSCSSYDQFKNFEERGELFIKLSKR 442 Rickettsia prowazekii st...
CAB74268     334 ISTEKMLDYAKKANLKAY---KCEVLSKAVNEISNHLRVNEVALLSPACASLDQFNSYAERGKVFKECVNK 401 Campylobacter jejuni sub...
WP_004082930 359 EISKELAPFVGKIPHS-----IVENMEEAFEKAMEVSEKGDVILLSPGGASFDMYENYAKRGEHFREIFKR 424 Thermotoga maritima
WP_010881357 344 ETKEKIKDSWKDITEVKT----CNTLEEAVKLAREVSKLGNVVLFSPACSSFDMFRNYEERGEKFKELVEI 410 Aquifex aeolicus
WP_002224926 377 VDAPQIRRDLDGCGLNMT---DCATLGEAVQTAYAQAEAGDIVLLSPACASFDMFKGYAHRSEVFIEAFKA 444 Neisseria meningitidis
WP_009872138 346 ECAQEIARDLEEF--PVT---VVKNLSEALLCAEEQAVPGDVIVLSPACASFDQFRSYEERGAMFKQLVGM 411 Chlamydia trachomatis
WP_014518191 346 ECRQTIADALSEKIPLT----LSKDLQEAVSIAQTIAQEGDTVLLSPGCASFDQFQSFEERGAYFKLLIRe 412 Chlamydia pneumoniae
WP_000703484 354 SSAFIIQALALEFNVSCQ---VCLELEKAVQEIKSVLSQNEIALLSPSAASLDQFSSYKERGEKFKAFVLK 421 Helicobacter pylori
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