Conserved Protein Domain Family
HdeA

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cl05752: HdeA Superfamily 
HdeA/HdeB family
HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localized in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that HdeA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. The gene encoding HdeA was initially identified as part of an operon regulated by the nucleoid protein H-NS. This family also contains HdeB.
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Statistics
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Accession: cl05752
PSSM Id: 446773
Name: HdeA
Created: 8-Feb-2008
Updated: 8-Mar-2022
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