Conserved Protein Domain Family
SART-1

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pfam03343: SART-1 
SART-1 family
SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.
Statistics
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PSSM-Id: 460888
Aligned: 102 rows
Threshold Bit Score: 187.934
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O01524              111 KDIKEKLEIAKAKRDVYSKVLkAKKLADS-D-EE---DSAASFVNKMR-QKEDeakkAADRAAAFDqLDEELGvs----- 179  Caenorh...
XP_002506343         80 AALAAKIAAAKEKRTMEQRNRaTKQLGEaadaDD---DDMMAWVNKSR--KIEekrrKEERKKAEE-----LArkl---- 145 
XP_004343271         73 KTLEERLAAHREARRIEDSLKaTKTLGA----ADkegDSASSWVTQSRkAQDAqrkaAEARLRAFDeLDEQAStsigs-- 146 
XP_004992299         60 AELRDKLKERKEKRSVEAKLRsVKTLGEad-dDD---DSAAAWVKRSR-AKKQ----AQRQAKMLQdMDEQLTgsssasa 130 
CDS40635            151 EKLQEKITTAKEKRELLSKLReVK-SLGS-G-EE---TSVSSWVEKMR-SKEKakleAEKREQMLTeMDAVFGvsa---- 219 
XP_001606055        233 EKLRERLATTKQKREIQSSLAaIKTLGEG-DdDD---LNTEKWASKFT-QIQDekrkAAERAKMLDqMDEEFGgig---- 303 
XP_002431526        161 EKIKERLSERKEKREIEKKLKaFKGLGDE-SeSD---EDVKSWVKKSR-QKELerkqAEAREKLLDeLDEEFGvgs---- 231 
WGS:AAQB:GK14964-PA 280 EKLRDKLNLRKEKRFLEERLArIKTLGES-DeET---DNTSKWVDRNK-RVVNereeAKRKAKELEeLDEAFGvae---- 350 
Q9VKD8              345 EKLREKLKQRKEKRFLEERLArIKTLGES-DeET---DNVSKWVDKNK-RVVNereeAMRKAKELEeLDEAFGvse---- 415  fruit fly
EFA10481            138 EKLKGKLTTIREKRQLENKLGkVKLLGDS-D-SD---DNVESWVDKNR-KIELakkeAEKRAKMLEeLDEQFGvse---- 207 
O01524              180 --------aIVd-KVKKPKKPKTkgPSDTAGMVIGHGREAFIEGDQ-ILVLQDKGV--LDD-----G--DEVLVNPNLLD 240  Caenorh...
XP_002506343        146 ------aeqDDeaEESEGDEIYG--GKDLAGMRVRHGLEDVAEGETmILTLKDSSI--LDDklqgiNeeDDELENVNVAQ 215 
XP_004343271        147 ----skpkpAQkkAAATGAQSYD--SSNLAGLKVAHDVEDFEEGSt-VLVLQDTGVldDDN-----E---DVLENVNMAD 211 
XP_004992299        131 saggssrkrKGskNPTIKQEEYT--STDLRGMTVRHDLDQFQEGAQtILTLEDRGVldDDE-----E---DVLVNVNIAE 200 
CDS40635            220 -------vvEEriRPKALKPEYS--SASLEGLKVEHSVDRFSEGKPiILTLKDSDV--LAE-----Da-SDVLTNVNLED 282 
XP_001606055        304 ------nlvKEdiRNDL-KNAYT--NKDLRGLKVEHSLNNFNEGSSvILTLKDQAV--LAE-----E--DDVLVNVNMID 365 
XP_002431526        232 -------lvEEekKDFH-KNAYT--AKDLKGLKVGHSLLGFRDESSlILTLKDQEV--LGE-----G--DDVLVNVNMIE 292 
WGS:AAQB:GK14964-PA 351 -------mvEEekQKAR-QRAYG--DNSLKGLRVDHDMDDFGEGRTvILTLKDQDV--LNE-----Ed-GDTLVNVNMLD 412 
Q9VKD8              416 -------ilEQekTKAR-QRAYG--DSNLKGLRVDHDMDDFGEGRTvILTLKDQDV--LNE-----Ee-GDTLVNVNMVD 477  fruit fly
EFA10481            208 -------fvENekKEKR-KQRYT--ERNLKGLRVEHDVDSFAEERDvILTLQDKGV--LDE-----Dk-EDVLVNVNMVE 269 
O01524              241 NERHVRNVElRKRkD---PNRNFde--dVDEFGNaKN-FG-VLAKYDE---TLeg---eqKKQFRLde-hgGVDLEEERR 306  Caenorh...
XP_002506343        216 ERKRQKAKKaATKrSd----NPFgaddeDAG-------KK-ILSKYDEe-----------DEDEGLtldaaGAIDAAEEK 272 
XP_004343271        212 HERAKQNAIrRANsKr-pGYNPLvgedgNDSGLGa---PTgLLSHYDEweeELkgd--rkLKKLTVldaqgSADTAEKKL 285 
XP_004992299        201 DEHAKRRVAeAQRsG---GYDPKrglddDDEDTLlGLkKKsVLDKYDDidsltgdkklkeTKTFRIgfedeK-------- 269 
CDS40635            283 EERAEKNREnQRKlA---GLGGIlqdedDDVVMGlRE-KG-ILEKYDV---EIsg---pkKAEFILea-ngTYATDHE-R 349 
XP_001606055        366 DERYKKNVLvKSKkP---GYDAYde-shYDEYGMpLG-K--VLDKYDE---EIeg---ekRDSFAIgm-vdAKEIKER-Q 430 
XP_002431526        293 NERYKKNIEiKRKsT---KYDd------MDNFDDpLV-EKsVLSKYDE---EIdgp--ktEEGFRLg--------EED-S 348 
WGS:AAQB:GK14964-PA 413 DERYKKNVAnKKQnPlsyGYDVYee--qYDELGNpIE-RS-ILEKYDD---DIdgk-pkkRKNFVIge-nvEEQRDQR-R 482 
Q9VKD8              478 EERYKKNVAnKKQnPlsyGYNVYee--qYDELGNpIE-RS-VLEKYDD---EMegq-pkkRKNFVIge-nmDEEREHR-R 547  fruit fly
EFA10481            270 DERYKKNVInKKKkI---LYNAYed-qeYDEFGNpKE-KS-LLAQYDE---TIdg---ekRESFKIg-----YDNAVERK 332 
O01524              307 EM--EAFRRMKM-AGKrlESL-ETKkye----------laSEFYTQDEMtq--frKVKKgKKEk------NIRKRkv--- 361  Caenorh...
XP_002506343        273 Rk--ADIKRRLA------ASLgGVsvnavaetadvrkremSEFMSAAEVaeeaaaKFNKpKKKrr----kKLREKkfdis 340 
XP_004343271        286 E------QEFFAkQRAkaVSLdSDtrt-----------svSDFYTPEEMi-----SFKKpSKDkk---hkKRRTRdrtqd 340 
XP_004992299        270 -SseEQRKEEVRqRLLqaESL-EFkhn-----------avSDFYTEEEMe-----KFKKkRKKrkakgrkKTRRVraddl 331 
CDS40635            350 AL--RRLQEELQ-TTr--QSL-EDQelr----------paADFYTEDEMa-----QFKKkKRR-------KV-QRri--- 397 
XP_001606055        431 AA--M-VKNRLA-NKr-lESL-QLAepk----------iaSDYFNESELe-----KFKKtKKKv-----rKLRTKkt--- 481 
XP_002431526        349 QL--EKVKRKLA-LQi--NCW-KGDppr----------ikSKFRN----------KIKCeRNRa-----kKLRKKpkm-- 395 
WGS:AAQB:GK14964-PA 483 KL--LEIKTKLA-GKr-lETL-QDTnlq----------laSDTYSTAELa-----TFKKpKKKi-----kKLRQkl---- 533 
Q9VKD8              548 KL--LEIKTKLA-GKr-lETL-EDTnlq----------laSDTYSAEELa-----KFKKpKKKv-----kKLRQkl---- 598  fruit fly
EFA10481            333 QAivQSIKEKLA-KKr-iESI-ETKdlk----------laSEYYNDEELs-----KFKKpKKKv-----rKIRTKgk--- 386 
O01524              362 lkASDLvpVe-----kA-GEGRDFgrrrrdsdepedeglkkekqdgkdedgeisdkevpesssdngkwkkamrgngvdlq 435  Caenorh...
XP_002506343        341 eiENDHlaQaaqekqeAaAEPERA-------------------------------------------------------- 364 
XP_004343271        341 adDDEDdsIatqqsasGvVRSKRKapsgedged-------------------------------------------eddv 377 
XP_004992299        332 lgLDDEe------------------------------------------------------------------------- 338 
CDS40635            398 lrADDLipDpgs-astVs--TDHGsrgrremqetagpalkeegevvdvkk---------veedikppalapltglnpaia 465 
XP_001606055        482 lkADDL--Lss----aNdYLKDLGsrrrrh-------------------------------------------------a 506 
XP_002431526        396 lkAEDL--Lpqq--emTwPSEDLGsrrlknsvppe---------------------------------------kisaav 432 
WGS:AAQB:GK14964-PA 534 -kAEDL--Eqla-epsTsGSSNFGsrh----------------------------------------------------- 556 
Q9VKD8              599 -kAEDL--Apla-mgeAsGSSDFGsrg----------------------------------------------------- 621  fruit fly
EFA10481            387 ltADEL--Eqq---inNkGIEEVG-------------------------------------------------------- 405 
O01524              436 rlqkLRSKHqiaeDDDSDNDlmfsggv--------------------------------dltgvviDDNAEe--eLSSIL 481  Caenorh...
XP_002506343        365 ----RGr-----fRNDAGEEerklmgfqnalnkak-----------------iktderilaemagdvEDEDt--eLAMAL 416 
XP_004343271        378 qpavTVRHLlnnsQAMDTSSsasgpdrgsrkrgrhdddehseatislpepgqfqalkpvtdasfdfVADDEgeveLARAL 457 
XP_004992299        339 ----eQTQPeaegDTMETGAdvshavrdeedi------------------------lnqandaeleaaEREleaeLQASL 390 
CDS40635            466 allsVQTIPeeeeQIDAGDEdvanqw----------------------------------saeplePDNLQl--eLEKTL 509 
XP_001606055        507 gdilDN------------DDlggpted--------------------------------lsgvkieDDDHDl--dRRMK- 539 
XP_002431526        433 entiKKel---ieDVMDVDDlpppvdd--------------------------------lsdikleADEGEl--eLQLAL 475 
WGS:AAQB:GK14964-PA 557 -gryRD-----------ADDiemkdeeqet---------------------------kstqiklelDDDDDl----ERVL 593 
Q9VKD8              622 -gryRD-----------HEDaemeefk---------------------------------pqikveVEDDDl----ERVL 652  fruit fly
EFA10481            406 ----SR-RPkkelEDLTIDDipemeyp----------------------------------tdvkleDEKDd--lLEKAL 444 
O01524              482 AKTRKv--K---Q------IDgkqmdndvgKKV--QDILTSHGVKme------iD-EEEDvkplkeGQIYIDSTTEYCRH 541  Caenorh...
XP_002506343        417 ERTKRlaerg----------------vgarSDVdvARVAAARRATdapdvgergAsG---------EGMVFNDVQEFVHG 471 
XP_004343271        458 ERTRRl--KqqaEgflagpA---------------VPAVRPKSEDs----------tEDSaasagdSSLVFSATSEFVKN 510 
XP_004992299        391 TRARRarkNaykK-----------------KDV--TELLDAAVKKs----------kENNngssagGGVVFSTMSEFVRG 441 
CDS40635            510 SRVRNt--Nlakcv------------pqpeERL--QMVMKEVESEtfv-----pkaQ-NGnsggdgGGLVFDATAEFFKQ 567 
XP_001606055        540 QKWKKi--K---Ap----aPSik------pEEI--ALTIKQEAdm-------tnE-TDSa------GNIILNSTAEFCRT 588 
XP_002431526        476 NKARKl--K---Lk----dRq---------NNS--ADTIAKEIINts-----tsH-NNDgp----gGTIILNSTAEFCRT 525 
WGS:AAQB:GK14964-PA 594 SKARRl--K---Qk----eNIikkslpidvAAI--ERDIKPEPVQev-----nsA-TSGIilsgtdNNIVLNATAEFCRT 656 
Q9VKD8              653 AKARKl--K---Qk----eNIikkplpvdfESI--QREIKPEHVEd---------tASGVvltgvdGNIVLNATAEFCRT 712  fruit fly
EFA10481            445 HKTRKi--K---Qk----eNLv-------------AEIVKSTPVKsese-------------enleGSIVLNATAEFCRT 489 
O01524              542 VGEITTLG-------LGGnrtvdvsevk-----------------------------------kvkeeemeqeGSEGFEk 579  Caenorh...
XP_002506343        472 INVEDKRAtrs--eaAAAgdmppvpppppgsgdmppvpppppgsdvdgmppvpppppsgvgaeeeheddevnpLDG---- 545 
XP_004343271        511 IGARDLKPdpvqtqpAKPasfvpalvsqaqqpagvtapmdivsvgvpaanrtrrtklvgddeaeamdtqpikkEESKSDd 590 
XP_004992299        442 IGANSKDDdqprkrnKQGssssatatatagatetsapp----------------vpaapasssssassaaaaaMETGEDk 505 
CDS40635            568 ISG----GlqndvtaKMVkreaeaeleea--------------------------------------evevqrrqpvREk 605 
XP_001606055        589 LGDIPTYG-------QAGnrdenh--------------------------------------------qefmdFEVNEVk 617 
XP_002431526        526 LGDIPTYG-------LSGnreede--------------------------------------------qelldFEREIKe 554 
WGS:AAQB:GK14964-PA 657 LGDIPTYG-------MAGnrneds--------------------------------------------ndmmdFDNNEQq 685 
Q9VKD8              713 LGDIPTYG-------MAGnrneds--------------------------------------------ndmmdFDKTEqp 741  fruit fly
EFA10481            490 LGDIPTYG-------KSGnreet---------------------------------------------edlidFERDLKd 517 
O01524              580 wk------rakVDKelkekekrklrd---qggwlaagepaPSNARIDSDDEDALEEAKkRKWSEdeeeDEDMEEDKDDYa 650  Caenorh...
XP_002506343            --------------------------------------------------------------------------------     
XP_004343271        591 knd---------------------------------------------------------------------------fq 595 
XP_004992299        506 aeeggdgdgtgRYF--------------------------QSSFTTDQATTDAEHAERkTEVDDt--pV----------- 546 
CDS40635            606 dsrserapekkERHrdssgrytsstkhsssshrhyeekasMSKSSGSSTRSKE------GKEREdisaISFTPTASAGGg 679 
XP_001606055        618 q--------ecVDEemngk-----------------sawnTV---------EV------DD-V------TVVPFTTEAAi 650 
XP_002431526        555 ek--------kklTddkkn----------------vgawnEV---------EL------DE-------HSADLLPKEVSi 588 
WGS:AAQB:GK14964-PA 686 md------ehmDGHgdeasvsg-----------hghgtwnSV---------NP------DEVMQpadfDNLGDDLEDRAi 733 
Q9VKD8              742 e-------ehmETHtdepal--------------shgtwnSV---------NP------DEVMQpadlDNLGEDLEDRAi 785  fruit fly
EFA10481            518 ep-------emDEVeqeek-----------------tgwnSV---------DP------NE-------PHESPQIAPQEv 551 
O01524              651 paLGQEVDV-SKGVGRMLKLAGQKGYLQ------------------------------------NP---NAKShsgpsld 690  Caenorh...
XP_002506343        546 ---VQANPMgS-GLAATLALLKETGKLH---------------------------------------------------- 569 
XP_004343271        596 dfLTEEPSLvN-GVGAALAFMARRGMIEneskaqgvvvvetdrqrdkgkqrmdqeeerkieleiRRqreAERN------- 667 
XP_004992299        547 --LGEEGNVgS-SVTAALNLALRKGYLAqkkkkqqqqqee-------------atasrlaeltsKNaqqEEHG------- 603 
CDS40635            680 -vFEEEPAL-NQGVFSALLLAQKKGYVE------------------------------------EE---KEKErpmgqlv 718 
XP_001606055        651 --LDAEPSL-DQGVGGALKLAMSKGYLQ------------------------------------KE---DSNRpsanqla 688 
XP_002431526        589 --LDAEPDV-GSGVAGALRLALSKGYLE------------------------------------KE---TENRpsasrfa 626 
WGS:AAQB:GK14964-PA 734 --LDEEPDV-GAGVANALRLALSKGYLE------------------------------------KE---EKNRpsntkma 771 
Q9VKD8              786 --LDEEPDV-GAGVANALRLALSKGYLE------------------------------------KE---EKNRpsntkma 823  fruit fly
EFA10481            552 qiLDEEPDV-STGLGAALKLAMSKGYLD------------------------------------KE---QNKRpsnsrla 591 
O01524              691 hLKNKTtQRIDGQRFDPDDRNAKKADRLNSQH-RGPVM-PFAeKhDYKPDVNISYVDRKGREMDAKDAYRELSYKFHGRN 768  Caenorh...
XP_002506343        570 --------ENDMWDGRTNDKKPLALMRVREAAeITGAEfE-----GHKFDFKLDRYDEFGRKMTPKEAFRELCHRFHGIE 636 
XP_004343271        668 -RDRRD-RRDVRDSRSDRDRNDRPPERDREADpFSMPA----------PEFTLDYVDENGRTMTTKEAFNHLSYKFHGIQ 735 
XP_004992299        604 -PEDDDhGRDSRSSRDWRRDSRRDRDRG-----------DPFeKrGYQPSFRLSYTDNTGRELTPKEAFTYMSHQFHGKT 671 
CDS40635            719 nLMAKHyVKEDVRYDDIDAKFAKR-ERYN-----GPLC-DFReKsSYKPDVKLYYVDEMGRNLTPKEAFRQLSHKFHGKG 791 
XP_001606055        689 hLRAQNySIEDKTYGDD-DKFGRR-D--R--Y-NGPTS-EFTeKiGYRPILKLEQIGDDGRVLTTKEAFRYLSHKFHGKG 760 
XP_002431526        627 hLQAQNySIEDKSHGDD-DKFGRR-D--R--Y-IGPTT-DFKeKdNYKPNVKLDYIDDEGHILNAKEAFRYLSHKFHGKG 698 
WGS:AAQB:GK14964-PA 772 hLQAKNySIEDKAAGEE-EKVGRR-D--R--FhSGPIM-DFKdKeTFKPNVKLDYIDDNGRILNLKEAFRYLSHKFHGKG 844 
Q9VKD8              824 hLQAKNySIEDKAAGED-EKVGRR-D--R--FhFGPIT-DFKdKeTFKPNVKLDYIDDNGRILNLKEAFRYLSHKFHGKG 896  fruit fly
EFA10481            592 hLQAKHySIEDKTYGDEGDRANRR-ERYT-----GPIM-EFKeKdGFKPNVKLEYIDDDGHVLNSKEAFRYLSHKFHGKG 664 
O01524              769 PGKKQLEKRANRKDKE 784  Caenorhabditis elegans
XP_002506343        637 PGRAKKEKRLRAYQEE 652 
XP_004343271        736 PGKNKQEKRQRKLEEE 751 
XP_004992299        672 SGRMKTEKKLRKRQQE 687 
CDS40635            792 SGKKKTERRTKKIIEE 807 
XP_001606055        761 PGKNKVEKRMKKAEQE 776 
XP_002431526        699 PGKNKVEKRMKKNEQE 714 
WGS:AAQB:GK14964-PA 845 PGKNKIEKRLKKMEQD 860 
Q9VKD8              897 PGKNKIEKRLKKMEQD 912  fruit fly
EFA10481            665 PGKNKIEKRIKKGVQE 680 
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