Conserved Protein Domain Family
PNGaseA

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pfam12222: PNGaseA 
Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A
This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 558 and 775 amino acids in length. There is a conserved TGG sequence motif. PNGase A is a protein which cleaves glycopeptides.
Statistics
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PSSM-Id: 403439
Aligned: 21 rows
Threshold Bit Score: 451.415
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERT01665     120 PVLTPDGPATerssg----------pssasGAVTVTLMEHVFGNSYNAPFVGSYV-PP-AT----PFNRVVMNFTATSAG 183
EDN94889     199 PVLIPPGVTDetasyngvedtaiiastndaTSCKVVLMEHTFGYSYGIPFVGNYT-PP-GC----KFNRVVMNFTVTSSG 272
EGZ74538     187 PIPAGSTQE----------------------ACTVLLMRHDFAFSYGVPYIGDYT-PP-SC----KFNRIVMNFTVVSEG 238
Q0UTT9        59 PILSPSG------------------------GCQQTLMVYTFALSYGQPFVGDYA-PP-EC----DFNRVAIEFTVTSAG 108 Parastagonospor...
XP_006685489 140 PDVVNPSYGK--------------------SLQHELLFNHTFGNSYGSPFVTTYT-PPsGI----EFNRVVLTLDTYVSG 194
EDK36913     153 PFVPPKWYGS--------------------PVYESLLLNHTFGNSWGNPAETKFV-PPsNV----SFDKVVLTLRTTSSG 207
XP_002494029 109 P---SPNFGVp-------------------VFESVLLDSYEFGDSWGHPALTTYVaPPaAI----KFNKVVLGLDIYVSG 162
EFJ00017      29 PPPLPVGVQ----------------------ECTITVLQRDFANSYGDAEVVQLE-PPtECgdpgSWSAVSLNLTVTSNG 85 
EMD38307      31 PPPLPQNTK----------------------QCTVQILERTFGFSFGDPEIVQLT-PPtDCgpvgSWAGISLNFTVTSNG 87 
XP_007395826  31 PPPLPQDAK----------------------QCTIQILERTFGNSFGDPEIVQFT-PPtDCgsvgSWAGISLNFTVTSNG 87 
ERT01665     184 RQFDRLALMYLNDTEVWRTSTAEPVKApGIRWVYLKDTTAYLALWR-TPQKIIFDLGNLQNDVYTASFNVTLTATFFQSD 262
EDN94889     273 RQFDRLAIMYFGDSEVWRTSTAEPTTA-GIRWEYLKDMTEYLYFWN-SPQTLIFDLGNLIDSTYTGYYYTTLTATFFTSQ 350
EGZ74538     239 RQYDRLALMYLGDTEVWRTSTAEPVAPpGIRWEYLKDMTEYLSLWQ-QKQKIIFDLGNLVNDKYTGIFNTTLTATFFYSD 317
Q0UTT9       109 RQFDRLALMYLDDIEVWRTSTAEPTSS-GIIWTYTKDMSAYSVLFR-SPHKLIFDLGNLIDDTYTGSWNTTLTATFFTAD 186 Parastagonospor...
XP_006685489 195 VQYDRLAHLFVSGVEVWRTSTIEPGGK-PSHSNFVKDVSDYAILFQ-DEATLSFSLGNIVNDKYTGSFELNMYIDYYYDE 272
EDK36913     208 VQYDRLANLFVNGVEIWRTSTAEPGGR-SIVSLATKDVSVYTELFR-NPASILFDLPNILTGRLTGSFHVQLSIQLYDSH 285
XP_002494029 163 VQYDRLAHIYLDGSPLWRTSTPEPGNR-HVHSLSHKDVSEYVPLFKeNGTELMVQLDNLLTGRLNGSFEVTLTARYYDSF 241
EFJ00017      86 TQYDRLGIFTFQNVEIWRTSTPEPTRGdGIIWTYIKDVTQYIPLFA-KPGTFILQLDNIIQDNLDGVYSTTVTATYYAAT 164
EMD38307      88 TQFDRLGIFTFQNVEIWRTSTPEPTIGdGIIWTYIKDVTRYIPLFS-KPGTFILQLDNLLETGLDGQYATILQATFFASS 166
XP_007395826  88 TQFDRLGIFTFQNVEIWRTSTPEPNIGdGIIWTYLKDVTRYLPLFA-KPGTLILELDNLLETGLDGQYATTLHATFFASS 166
ERT01665     263 vgd---------------------rldAAPPSDAVIPISKRQSDVNGVSQFTLPAD-VATNTITdFPRNARRAVFSVSAN 320
EDN94889     351 e--------------------------TVEPADLILPISARHGADDSVSVFTLPGD-NATNTIA-FPRNANRAVFSISAC 402
EGZ74538     318 va-----------------------tnAAPPSDLIIPISARQSANNAVSQFTLPTQ-NATNTISdFPLNARRAVFSVSAN 373
Q0UTT9       187 d--------------------------TTKPADIILPVSARRSAANQPSAFVVPDT-KAINTLE-LPKNTEKAVFTISAC 238 Parastagonospor...
XP_006685489 273 tvgsqfgpvp-------dinditdlilTNTLPSKIVSLG---STSESSPQISLPDT-QFIAQLPeLNTNTSKLRLSIFTS 341
EDK36913     286 geadesdpe---------iqskasifsTHKPASRVHAILP--SRPHKPSVVYLPSD-KIRVQLPtVPQNTTRLRLSILTS 353
XP_002494029 242 lndtapvkiagidddlfipgshvqffsANEAASKVFPLVD--TPPTRPPLIYYPDR-KFQVTLPvLSPNTTRVKLALFTS 318
EFJ00017     165 ge-----------------------ypTAKQADTILPIST--GANDTGNDASVPPGfSTNVT---IPVNTIKLFAEIFAS 216
EMD38307     167 pe-----------------------hpPAPKANTIIPVTT--LANNTGNEASVPPDfSLNVT---VPRNAVQIFAELYAS 218
XP_007395826 167 aq-----------------------npPAPRADLIVPITT--LANNTGNDASVPPIfSLNIT---LPQNTVEVYAELQAS 218
ERT01665     321 GQANEEFWWSNVLQSDTLTFNATgAGVFPGFSPFREVQVLIDGQLAGVQWPFPVVFTGGVVPSLHRPIVGADVFDLREHE 400
EDN94889     403 GQSTEEFWWGNVLQSDIEAFEDY-DGTLYGYSPFREVQVLIDGQLAGVQWPFPVVFTGGIVPGLWRPIVGLDAFDLREHE 481
EGZ74538     374 GQGNEEFWWSNVLQSDTNAFSDT-VGELPGYSPFREVQILIDGHLAGVYWPFPVIFTGGVVPSLHRPIAGIEAFDLKEHE 452
Q0UTT9       239 GQAAEEFWWSNVFNSDTKAFGN--DTTLYGHSSFRELQLLIDGNLAGVAWPFPVIFTGGIVPGFWRPVVGIDAFDLKEDE 316 Parastagonospor...
XP_006685489 342 GNSQEEFWYTNILDAYVSGFAAE-GVEFYGHGPIRHVEVYFDGQIVAAVAPDPVIFTGGISPSLWSPVVSNDAFDLKPIN 420
EDK36913     354 GNAAEEFWYANVLDKYAHRFDEQ-GNTLQGHGPTRFVNVNFNGEKIATQTPDPIVFTGGISPALWSRVVATRAFDLPTID 432
XP_002494029 319 GNAAEEFWYSNILDGFEDYFSDH-QHYLAPHGPCRMVNVYINGIRIASLSPEPIIYTGGISPALWSPIVSTSAFDVRALE 397
EFJ00017     217 GNGQEEFWYGNIPNAYLSSLP---DGLTYGQGPFREVRLLIDGRVAGVAFPFPVIFTGGFSPPAWRPINAINALDLPRYA 293
EMD38307     219 GNGNEEFWYFNTADEFVNDLP---AGFTFPDGPFREVRMLVDGQLAGVAFPYAVIFTGGILPSCWRPITSYGALDLPTYF 295
XP_007395826 219 GNGDEEFWYFNTANEFINDLP---SGESLPNGPFREVRLLVDGQVAGTAFPYPVIFTGGIAPPAWQPITSYGALDLPNYY 295
ERT01665     401 IDISPWLPVLCDGQ---PHTFSILVAGLDDd--gQPSGV-ASLTKQVAASWYVTGKIFVWLDDND-----GDDSSALVTT 469
EDN94889     482 IDITPWLPILCDGS---EHTFEIRVAGVID----DEEGS-GTLIDTVGSYWLVTGKIFIWLDSND-----------SVTT 542
EGZ74538     453 IDITPWLAVLTDGK---PHEFTIRIAGINDtassSSSGHnAVLTDHVNESWYVTGKIFIWTDSHShsnsiGSNNNNNNND 529
Q0UTT9       317 IDITPFLPLLNDGN---THAFEIRVVGIDD----DGKGN-GQLTENIESNWVVTGKIFIWTGTAM-----------NLSI 377 Parastagonospor...
XP_006685489 421 IELTVLLPKIQANP---DGKLEIKIDNGVD-------------HKSVGSNWITTANLHVWENSHV-----ESSTGSSSQA 479
EDK36913     433 LDVTGLLPLLWEHQavtDRILEIEISNGID----ESNRPfLPEHSQIGENWITSANLLSWENSEV-----VESSGDIVNI 503
XP_002494029 398 FDLSTILPYLWDSE---DTVLEVEISNCIQ----DQEETeASAGNTIGQNWVTSANLLTWEHSSI-----KSSEGTVISN 465
EFJ00017     294 IDVTPFVPLLTDGE---PHNYTLDVASAEE-------------DHAILGNWYVSGLLQVVTGNSE-----GRTTGNMTVY 352
EMD38307     296 IDLTPFVPVLTDGN---PHNITIDVTSAEA-------------DHAINQNWFVSGNLQVVTDPSP-----KPTTGTITVY 354
XP_007395826 296 LDVTPFVPLLVDGN---PHNFSLDVVSAET-------------DHTINQNWFVSGLLQVITDPSG-----KPTTGKINVY 354
ERT01665     470 GTP--PVVHDAGV--AISVTQHLQQN-ATGANQTLTYSVSVARSFSVQGTlrtgakgprAVSWSQSLSYANEGALTDFGN 544
EDN94889     543 GTA--PKIFLPAP--IITTSHVLTQN-ASGANETLTYITNVQRSLSISSTiite-ngttTSTWTQELSALNYGQYTAFGA 616
EGZ74538     530 NKL--PTIDGLTPliTVSSIRAPPSSsNSSTPESITYTTSVKRSLRVRSP---------LVTWTQTLSYTNKGLVSAQGY 598
Q0UTT9       378 GTV--PIISAPAP--SIKLQSITKRS-VNGTVSALDYSIQVSRQLSVESTimts-agsqTVSWKQDLTFSNTGTLSNGGN 451 Parastagonospor...
XP_006685489 480 LTN---RYCTQIVinSTSLHQTLVCEdDVKLHSSLSFTLADSSVVSG------------PVELEFKTSTTNIQIISSDGL 544
EDK36913     504 DDKarATVVSLAPpfSGTIQQVITSIlNTEVTSNLTFVLENDQEIKT------------TVTALTKGEIANVQHYSHFGS 571
XP_002494029 466 DNS--TEIKAKIFpgDSKLTQIVSARyKTAISAQLNYTFFNGSSLNI------------LFNNVYDSSQSNVQLYADYGN 531
EFJ00017     353 EVG--EYAETDTTg-------------GNTTEGAFEVEVDAKRSVHIESVlvdgdgeetTVVWAQDLGYTSKQTFSADYL 417
EMD38307     355 DAQ--PFAVSNISg-------------SVATNGDIIVTVNASRSIHIEADivsgsgahtHVVWSQQMEFSNTQFYLDDLI 419
XP_007395826 355 QAS--PFAETSTTg-------------SVGSNGDVNVTVKATRNIHVESTiisgsgtttNVVFTQSSSYSNTQNFLNNTF 419
ERT01665     545 NQINNFTLSGSDKASGDG--DAASKYSysTSYAYPT 578
EDN94889     617 IQINNATTYGIDTS------KLGSSTKykSEYTYPV 646
EGZ74538     599 NQFNDMLISGSESSS--S--SSSSTHDyeTSYTFPL 630
Q0UTT9       452 DQVDQQATKGTSI----------SSTGfsRSFDYPL 477 Parastagonospora nodorum SN15
XP_006685489 545 DQSVVHTGNTKMTVGVGS-------SYenIEFTYPL 573
EDK36913     572 VQSVVHVGHSSKNVTIAT--ENDELYKldTSYSYPL 605
XP_002494029 532 KQHVALIPSTKHSISLFDlkNQKEIYEvnSTFSYPL 567
EFJ00017     418 VQLIDQSTTGTITSTHNG--DTVVSDE----FSYPL 447
EMD38307     420 IQNVVQTASGTFLSTHNG--VTALQDI----FSYPL 449
XP_007395826 420 IQNVQQTATGSVLSTHNG--VASTVDN----YSFPL 449
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