Conserved Protein Domain Family
PspC_subgroup_1

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NF033838: PspC_subgroup_1 
pneumococcal surface protein PspC, choline-binding form
The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.
Statistics
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PSSM-Id: 468201
Aligned: 19 rows
Threshold Bit Score: 797.299
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAF73809   1 MFASKSERKVHYSIRKFSIGVASVAVASLFLGGVVHAEGVRSG--NNLTVTSSGQDISKKYADE---------------- 62  
AAF73792   1 MFASKSERKVHYSIRKFSIGVASVVVASLVMGSVVHATEKEGAt-QVPTSSNRANESQAEQGEQpkkldse------rdk 73  
AAF73811   1 MFASKSERKVHYSIRKFSIGVASVAVASLVMGSVVHATENEGTt-QAPTSSNRGNESQAEQRREldlerd---------k 70  
AAF73810   1 MFASKNERKVHYSIRKFSIGVASVAVASLFMGSVVHATEKKVTt-QVATSSNKANKSQTEYMKAak-------------- 65  
AAF73795   1 MFASKKERKVHYSIRKFSIGVASVVVASLFMGSVVHATERGGSt-PVATSSNKANKSQTEHMKAae-------------- 65  
AAF73797   1 MFASKSERKVHYSIRKFSIGVASVAVASLVMGSVVHATEKEVTt-QVATSSNRANESQAGHRKAae-------------- 65  
AAF73779   1 MFASKSERKVHYSIRKFSIGVASVAVASLVMGSVVHATENEGSt-QAATSSNMA---KTEHRKAak-------------- 62  
AAF73790   1 MFASKNERKVHYSIRKFSIGVASVAVASLFMGSVVHATAEGGNypSSPCSSSEANKSQTEHMKAaeqgkqhreidldrnk 80  
AAF73773   1 MFASKSERKVHYSIRKFSIGVASVAVASLVMGSVVHATEKEVTt-QVPTYSNMA---KTEHRKAak-------------- 62  
AAF73813   1 MFASKSERKVHYSIRKFSVGVASVVVASLFLGRVVHAEGVRSGdtPKVTSSGYADE------------------------ 56  
AAF73809  63 ----VESHLESILKDVKKNLKKVQHTQNVGLITKLSEIKKKYLYDLk-VNVLSEae---lTSKTKETKEKLTATFEQFKK 134 
AAF73792  74 arkeVEEYVKKIVGESYAKSTKKRHTITVALVNELNNIKNEYLNKI--VESTSEsq---lQILMMESRSKVDEAVSKFEK 148 
AAF73811  71 vkkeVREYKEKKVKELYSKSTKSRHKKTVDIVNKLQNINNEYLNKI--IQSTSTye--elQKLMMESQSEVDKAVSEFEK 146 
AAF73810  66 ---qVDEYITKKLQ-----LDRREHIQNVGLLTKLGVIKTEYLHRLsvSKEKSE------AELPSEIKAKLDAAFELFKK 131 
AAF73795  66 ---qVDEYVNKMIQ-----LDKRKHTQNLALNIKLSAIKTKYLRELnvLEKKSKk-----EELTSKTKKEIDAAFEQFKK 132 
AAF73797  66 ---qFDEYIKTMIQ-----LDRRKHTQNFALNIKLSRIKTEYLRKLnvLEEKSK------AELPSETKKEIDAAFEQFKK 131 
AAF73779  63 --qvVDEYIEKMLREIQ--LDRRKHTQNVALNIKLSAIKTKYLRELnvLEEKSK------DELPSEIKAKLDAAFEKFKK 132 
AAF73790  81 akkaIDEYIEKMLSEIQ--LDKRKHTQNFALNLKLSRIKTEYLYGLsvLKEKSEaelpskAELPSKIKEKLTAAFEHFKK 158 
AAF73773  63 --qvVDEYIEKMLREIQ--LDRRKHTQNFAFNMKLSAIKTEYLYG---LKEKSE------AELPSEVKAKLDAAFEQFKK 129 
AAF73813  57 ----VKSHLEKILSEIQ--LDKRKHTQNLAFNKKLSRIQTEYFYL--------K---------------------KKLKA 101 
AAF73809 135 DTLp---------------------tEPEKKVAEAQKKVEEAKKKAEDQKEKDRRNYPTITYKTLELEIAESDVEVKKAE 193 
AAF73792 149 DSSsssssdsstkpeasdtakpnkptEPGEKVAEAKKKVEEAEKKAKDQKEEDRRNYPTITYKTLELEIAESDVEVKKAE 228 
AAF73811 147 DLSsssssgsstepeasdtakpnkptELEKKVAEARKKVEEAEKKAKDQKEEDYRNYPTITYKTLELEIAEFDVKVKEAE 226 
AAF73810 132 DTLp---------------------tEPGKKVAEAEKKVEEAKKKAEDQKEKDLRNYPTNTYKTLELDIAESDVEVKKAE 190 
AAF73795 133 DTL-----------------------KPGEKVEEAQKKVEEAEKKAKDQKEEDRRNYPTITYKTLELEIAESDVEVKKAE 189 
AAF73797 132 DTN-----------------------RTKKTVAEAEKKVEEAKKKAKAQKEEDHRNYPTNTYKTLELEIAESDVEVKKAE 188 
AAF73779 133 DTL-----------------------KPGEKVAEAKKKVEEAKKKAEDQKEEDRRNYPTNTYKTLELEIAEFDVKVKEAE 189 
AAF73790 159 DTL-----------------------RPGEKVAEAKKKVEEAEKKAKDQKEEDYRNYPTITYKTLELEIAESDVEVKKAE 215 
AAF73773 130 DTL-----------------------KLGEKVAEAEKKVAEAEKKAKAQKEEDRRNYPTNTYKTLELEIAESDVEVKKAE 186 
AAF73813 102 ELAk---------------------tEVESEQAETTRLK------------------------KIKTDREEAELKV---- 132 
AAF73809 194 LELVKVKAKESQDEEKIKQAEAEVESKQAEATRLKKIKTDREEAKRKADaklk----eaveKNVATSEQDKP----KRRA 265 
AAF73792 229 LELVKVKANEPRDEEKIKQAEAEVESKQAEATRLKKIKTDREKAEGEAK------------RRADAKEQDESskrrKSRV 296 
AAF73811 227 LELLKVKAKESRDEKKIKHAEAEVESKQAEATRLKKIKTDRKKAEEEAKlke------aveKNAATSEQGKP----KRRV 296 
AAF73810 191 LELVKEEAKESRDEKKINQAKAKVENKKAEATRLKNIKTDREKA-EEAKrrada---klqeaNVATSEQDKS----KRRA 262 
AAF73795 190 LELVKVKAKGSRNEEKIKKAKAEVESKKAEATKLEEIKTERKKAEEEAKrkaea----------eeevKDKL----KKRT 255 
AAF73797 189 LELVKEEAKESRDDEKIKQAEAKVESKKAEATRLENIKTDREKAEEEAKrraeaklkesveKNVATSEQDKP----KGRR 264 
AAF73779 190 LELVKEEAKESRNEGTIKQAKEKVESKKAEATRLENIKTDRKKAEEEAKrkada---klkeaNVATSDQGKP----KGRA 262 
AAF73790 216 LELVKEEANKPRNEQKVKQAKAKVESKQAEATRLEKIKTDREEAEEEAKrraeaklkeaveKNTATSEQGKP----KGRA 291 
AAF73773 187 LELLKEEAK-TRNEDTINQAKAKVESKKAEATKLEEIKTDRKKAEEEAKrkaga---------eedkvKDKL----KRRA 252 
AAF73813 133 ----------------------------------KKIKTDREEAEDEVK--------------------DKP----KKRT 154 
AAF73809 266 KRGVSGELATPDKKENDAKSSDSSVGEETLPSPSLnmanesqtehrkdvdeyikkmlseiqldrrkhtqnvnlniklsai 345 
AAF73792 297 KRGDLGEQATPDKKENDAKSSDSSVGEETLPSPSL--------------------------------------------- 331 
AAF73811 297 KRGALGEQATPDKKENDAKSSDSSVGEETLPSPSL--------------------------------------------- 331 
AAF73810 263 NREVLGELATPDKKENDAKSSDSSVGEETLPSPSL--------------------------------------------- 297 
AAF73795 256 KRGALGEPATPDKKENDAKSSDSSVGEETLPSPSL--------------------------------------------- 290 
AAF73797 265 KRGVPGEQATPDKKENDAKSSDSSVGEEALPSPSL--------------------------------------------- 299 
AAF73779 263 KRGVPGELATPDKKENDAKSSDSSVGEETLPSSSL--------------------------------------------- 297 
AAF73790 292 KRGALGEPATPDKKENDAKSSDSSVGEETLPSPSL--------------------------------------------- 326 
AAF73773 253 KRAVPGEPATPDKKENDAKSSDSSVGEETLPSPSL--------------------------------------------- 287 
AAF73813 155 KRGALGEPATPDKKENDAKSSDSSVGEETLPSPSL--------------------------------------------- 189 
AAF73809 346 ktkylyelsvlkenskkeeltsktkaeltaafeqfkkdtlKPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYPTNTYKTLE 425 
AAF73792 332 ----------------------------------------KPEKKVAEAEKKVAEAKKKAEDQKEEDRRNYPTNTYKTLE 371 
AAF73811 332 ----------------------------------------KPEKKVAEAQKKVAEAEKKAKDQKEEDRRNYPTNTYKTLE 371 
AAF73810 298 ----------------------------------------KPEKKVAEAEKKVEEAKKKAEDQKEEDRRNYPTNTYKTLE 337 
AAF73795 291 ----------------------------------------KPEKKVAEAEKKVAEAEKKAKDQKEEDRRNYPTNTYKTLE 330 
AAF73797 300 ----------------------------------------KPEKKVAEAEKKVAEAEKKAKAQKEEDRRNYPTNTYKTLE 339 
AAF73779 298 ----------------------------------------KSGKKVAEAEKKVEEAEKKAKDQKEEDRRNYPTNTYKTLD 337 
AAF73790 327 ----------------------------------------KPEKKVAEAEKKVEEAEKKAKDQKEEDRRNYPTNTYKTLD 366 
AAF73773 288 ----------------------------------------KSGKR-SGAEKRC-RAEKKAKDQKEEDRRNYPTNTYKTLD 325 
AAF73813 190 ----------------------------------------KPEKKVAEAEKKVEEAEKKAKAQKEEDRRNYPTNTYKTLE 229 
AAF73809 426 LEIAESDVKVKEAELELVKEEANESRNEEKIKQAKEKVESKKAEATRLEKIKTDRKK---AEEEAKRKAEESEKkaaeak 502 
AAF73792 372 LEIAESDVEVKEAELELVKEEAKEPRNEEKVKQAKAEVESKKAEATRLEKIKTDRKK---AEEEAKRKAAEEDK------ 442 
AAF73811 372 LEIAESDVKVKEAELELVKEEAKESRNEEKIKQVKAKVESKQAEATRLEKIKTDRKK---TEEEAKRKAAEEDK------ 442 
AAF73810 338 LEIAESDVEVKKAELELVKEEAKEPRNEEKVKQAKAEVESKKAEATRLEKIKTDRKK---AEEEAKRKAAEEDK------ 408 
AAF73795 331 LEIAESDVKVKEAELELVKEEAKEPQNEEKIKQAKAKVESKKAEATRLEKIKTDRKK----AEEAKRKVAEEDK------ 400 
AAF73797 340 LEIAESDVKVKEAELELVKEEAKESRNEEKVNQAKAKVESKKAEATRLEKIKTDRKK---AEEEAKRKAAEEDK------ 410 
AAF73779 338 LEIAESDVKVKEAELELVKEEAKEPRDEEKIKQAKAKVESKKAEATRLENIKTDRKK---AEEEAKRKAAEEDK------ 408 
AAF73790 367 LEIAESDVKVKEAELELVKEEAKEPRDEEKIKQAKEKVESKKAEPTRLEKIKTDRKK----AEEAKRKAAEEDK------ 436 
AAF73773 326 LEIAESDVKVKEAELELVKEEAKGSRNEEKINQAKAEVESKKAEATRLEKIKTDRKK---AEEEAKRKAAEEDK------ 396 
AAF73813 230 LEIAESDVKVKEAELELVKEEAKESRNEEKIKQVKAKVESKKAEATRLENTSRQIRKkaeEEEEAKRKAAEEDK------ 303 
AAF73809 503 qkvdaeeyaleakiaeleyevqrlekelkeidesdsedylkeglraplqskldtkkaklskleelsdkideldaeiakle 582 
AAF73792     --------------------------------------------------------------------------------     
AAF73811     --------------------------------------------------------------------------------     
AAF73810     --------------------------------------------------------------------------------     
AAF73795     --------------------------------------------------------------------------------     
AAF73797     --------------------------------------------------------------------------------     
AAF73779     --------------------------------------------------------------------------------     
AAF73790     --------------------------------------------------------------------------------     
AAF73773     --------------------------------------------------------------------------------     
AAF73813     --------------------------------------------------------------------------------     
AAF73809 583 vqlkdaegnnnveayfkeglekttaekkaelekaeadlkkAVDEPE-TPAPapQPAPAPEKpaekpapapekPAPAPEKP 661 
AAF73792 443 ----------------------------------------VKEKPAeQPQP--APAPQPEK-----------PAPKPENP 469 
AAF73811 443 ----------------------------------------VKEKPAeQPQP--APAPQPEKpteep--enpaPAPKPEKP 478 
AAF73810 409 ----------------------------------------VKEKPAeQPQP--APAPKAA------------PAPKPENP 434 
AAF73795 401 ----------------------------------------VKEKPAeQPQP--APAEKPA------------PAPQPEKP 426 
AAF73797 411 ----------------------------------------VKEKPAeQPQP--APAPQPEKpteep--enpaPAPKPEKP 446 
AAF73779 409 ----------------------------------------VKEKPAeQPQP--APATQPEK-----------PAPKPEKP 435 
AAF73790 437 ----------------------------------------VKEKPAeQPQP--APAPQPEK-----------PAPKPEKP 463 
AAF73773 397 ----------------------------------------VKEKPAeQPQP--APDPQPEKpteep--enpaPAPKPEKP 432 
AAF73813 304 ----------------------------------------VKETPAeQPQP--APAPQPENpteep--enpaPAPKPEKP 339 
AAF73809 662 A--PAPEKP----------APAPEKPAPA----PekPAP----TPETPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWY 721 
AAF73792 470 AeqPKAEKPadqqaeedyaRRSEEEYNRLtqqqP--PKTekpaQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWY 547 
AAF73811 479 AeqPKAEKTddqqaeedyaRRLEEEYKRLtqqqP--PKTekpaQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWY 556 
AAF73810 435 AeqPKAEKPadqqaeedyaRRSEEEYNRLtqqqP--PKTekpaQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWY 512 
AAF73795 427 AeqPKAEKPadqqaeedyaRRSEEEYNRLtqqqP--PKTekpaQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWY 504 
AAF73797 447 AeqPKAEKPddqqaeedyaRRSEEEYNRLtqqqP--QKPeq--paPAPKIGWKQENGMWYFYNTDGSMATGWLQNNGSWY 522 
AAF73779 436 AeqPKAEKTddqqaeedyaRRSEEEYNRLtqqqP--PKTekpaQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWY 513 
AAF73790 464 AehPKAENRadqqaeedyaRRSEEEYNRLtqqqP--PKTekpaQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWY 541 
AAF73773 433 AeqPKAEKTddqqaeedyaRRSEEEYNRLtqqqP--PKTekpaQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWY 510 
AAF73813 340 AeqPKAEKPadqqaeedyaRRSEEEYNRLtqqqP--PKTekpaQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWY 417 
AAF73809 722 YLNSNGA--------------------MATGWLQNNGS--------------------WYYLNSNGAMATGWLQYNGSWY 761 
AAF73792 548 YLNANGD--------------------MATGWLQYNGS--------------------WYYLNANGDMATGWLQNNGSWY 587 
AAF73811 557 YLNANGS--------------------MATGWLQNNGS--------------------WYYLNANGSMATGWLQNNGSWY 596 
AAF73810 513 YLNSNGA--------------------MATGWLQNNGS--------------------WYYLNANGSMATGWLQNNGSWY 552 
AAF73795 505 YLNSNGAmatgwlqnngswyylnangsMATGWLQNNGSwyylnangsmatgwlqyngsWYYLNANGSMATGWLQNNGSWY 584 
AAF73797 523 YLNSNGA--------------------MATGWLQNNGS--------------------WYYLNANGSMATGWLQNNGSWY 562 
AAF73779 514 YLNANGA--------------------MATGWLQNNGS--------------------WYYLNANGSMATGWLQNNGSWY 553 
AAF73790 542 YLNANGA--------------------MATGWLQNNGS--------------------WYYLNANGSMATGWLQNNGSWY 581 
AAF73773 511 YLNANGA--------------------MATGWLQYNGS--------------------WYYLNSNGAMATGWLQYNGSWY 550 
AAF73813 418 YLNSNGA--------------------MATGWLQNNGS--------------------WYYLNANGSMATGWLQNNGSWY 457 
AAF73809 762 YLNANGDMATGWLQYNGSWYYLNANGDMATGWFQYNGSWYYLNANGDMATGwfqyngswyylnangdmatgwlqyngswy 841 
AAF73792 588 YLNANGDMATGWLQYNGSWYYLNSNGAMVTGWLQYNGSWYYLNSNGAMVTG----------------------------- 638 
AAF73811 597 YLNANGSMATGWLQYNGSWYYLNANGSMATD------------------------------------------------- 627 
AAF73810 553 YLNANGSMATGWLQYNGSWYYLNANGSMATGWLQYNGSWYYLNANGDMATG----------------------------- 603 
AAF73795 585 YLNANGSMATGWLQYNGSWYYLNANGDMATGWLQYNGSWYYLNANGDMATGwlqnngswyylnangdmatgwlqyngswy 664 
AAF73797 563 YLNANGSMATGWLQNNGSWYYLNANGDMATGWLQYNGSWYYLNANGDMATGwlqnngswyylnangsmatgwlqyngswy 642 
AAF73779 554 YLNANGAMATGWLQYNGSWYYLNSNGAMATGWLQYNGSWYYLNANGDMATGwlqnngswyylnangdmatg--------- 624 
AAF73790 582 YLNANGAMATGWLQYSGSWYYLNRNGAMATGWLQYNGSWYYLNANGDMATGwlqyngswyy------------------- 642 
AAF73773 551 YLNSNGAMATGWLQYNGSWYYLNANGDMAIGWVQYNGSWYYLNANGDMATGwlqyngswyy------------------- 611 
AAF73813 458 YLNANGSMATGWLQYNGSWYYLNANGSMATGWLQYNGSWYYLNANGDMATG----------------------------- 508 
AAF73809 842 ylnsngamvtgwlqnngswyylnangsmatdWVKDGDTWYYLEASGAMKASQWFKVSDNWYYVNGSGALAVNTTVDSYRV 921 
AAF73792 639 -------------------------------WVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDGYGV 687 
AAF73811 628 -------------------------------WVKDGDTWYYLEASGAMKASQWFKVSDNWYYVNGSGALAVNTTVDSYRV 676 
AAF73810 604 -------------------------------WVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDGYGV 652 
AAF73795 665 ylnangdmatgwlqyngswyylnangsmatdWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDSYRV 744 
AAF73797 643 ylnangamatgwlqyngswyylnangdmatdWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDSYRV 722 
AAF73779 625 -----------wlqyngswyylnangdmatgWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDGYGV 693 
AAF73790 643 ---------------------lnangdmatgWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDGYGV 701 
AAF73773 612 ---------------------lnangsmatgWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDGYGV 670 
AAF73813 509 -------------------------------WVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDGYGV 557 
AAF73809 922 NPNGEWVN 929 
AAF73792 688 NANGEWVN 695 
AAF73811 677 NANGEWVN 684 
AAF73810 653 NANGEWVN 660 
AAF73795 745 NANGEWVN 752 
AAF73797 723 NANGEWVN 730 
AAF73779 694 NANGEWVN 701 
AAF73790 702 NANGEWVN 709 
AAF73773 671 NANGEWVN 678 
AAF73813 558 NANGEWVN 565 
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