1BQQ,1UEA


Conserved Protein Domain Family
NTR_TIMP_like
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cd03577: NTR_TIMP_like 
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NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by non-covalently binding their active zinc-binding sites. This group contains domains similar to the TIMP NTR domain, which binds MMPs. Members of this group may or may not function as MMP inhibitors.
Links
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Statistics
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PSSM-Id: 239632
Aligned: 19 rows
Threshold Bit Score: 82.0214
Created: 29-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Metzincin-bin..
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:Metzincin-binding interface
Evidence:
  • Structure:1BQQ: Bovine TIMP-2 binds human membrane-type 1 matrix metalloprotease
  • Citation:PMID 9724659
  • Structure:1UEA: Human TIMP-1 binds matrix metalloprotease stromelysin-1
  • Citation:PMID 9288970
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       ##     ###                                           #                          
1BQQ_T        1 CS-----CSPv-------HPQQAFCNaDIVIRAKAVNKKEVdsgndiygnpikRIQYEIKQ----------IKMFKGp-- 56  cow
XP_780837    28 CM-----CQPs-------HPQQQYCKaNFVLTGHVLEKNPIddiql--rgrfgQFEYVINV----------DKIFKEnen 83  purple urchin
1UEA_B        1 CT-----CVPp-------HPQTAFCNsDLVIRAKFVGTPEVaqt-------tlYQRYEIKM----------TKMYKGfqa 51  human
ZP_01051411  20 CT-----CAKdpkvskkeEITEKYKRaDVVFSGNLIKKEVLnkark--rssadPVRYTFEI----------IKQYKGsf- 81  Cellulophaga sp....
AAK58952     10 CFavahaCKCekk--prpPLEKLLCQsQFVTHAKVTKKRIDg----------yFIYYDLEH----------KEVYKPkd- 66  dog hookworm
XP_873472    22 CE-----CKIq-------HPQTFYCMsDIVIIGNILEHGRDta---------lKRSYRINItqvrpnitqiLKIPKKi-- 78  cattle
AAA96176     21 CS-----CMEf------qSEKDGYCAtSWISKVKVVSKETDgl--------glMMSYRLEH----------LKVIKApe- 70  nematode
ZP_01059139  19 CD-----CDPp-------KITEKYTQsDFVANVTIIKIYPNqk---------nEHGYRADIk--------iNELYKGd-- 67  Flavobacterium s...
ZP_00657410  43 CP-----ASRt-------GLDQLTMQaDDVFTGAVEDRARQg----------rTIVYTVTV----------DRVYKGdl- 89  Nocardioides sp....
AAT59594     31 CE-----CMKv-------SPEERLQKtNVVFEGKVLEVQEKg----------gKMEILFEV----------KKIWKGt-- 76  Bacillus thuring...

Feature 1                     ##       #                 #                   # ###              
1BQQ_T       57 -----dQDIEFIYTAPaa---avCGVSLdig-gkKEYLIAGKAegn------------gnMHITLCDFIVPWDt--lSAT 113 cow
XP_780837    84 lkkgasGFPLSILPSPgd---slCGPKSlr--igTKYLIAGSVvg-------------geLHISACDWIQEWRd--vTQE 143 purple urchin
1UEA_B       52 l--gdaADIRFVYTPAme---svCGYFHrsharsEEFLIAGKLqd-------------glLHITTCSFVAPWNs--lSLA 111 human
ZP_01051411  82 -----sKSTIEILSEAsg---ssCGYVFsk---gLTYLVYTRAsshfndrfpqlvddknaHTTSLCSGNMLRKk--vDKK 148 Cellulophaga sp....
AAK58952     67 -----rSIPIELFSWRek---enCGVPDle--egKEYLIGGKVtdygd--------gdlvISVSRCDLLRNWTd--vSGE 126 dog hookworm
XP_873472    79 ------PPITSVYTPKdw---gsCGYEVrts-qqSQLLIAGYLrk-------------gaLYFTRCHMVYFWYr--lTDE 133 cattle
AAA96176     71 ----nmTLPETMNTATqe---saCGQTKfk--vgKQYIFGGSLann------------dsLLITFCDWRVPLKy---IDE 126 nematode
ZP_01059139  68 -----rLKSIYVYGRSdngigtsCDIYIp----eNTNLIAYASknk-----------dgnYGIGMCSGLLYLNkt-nQKR 126 Flavobacterium s...
ZP_00657410  90 -----dGTEATVTTPAra---raCGLPDlr--tgTDYVFFTQGa---------------dLETTSTAGTAPAAatllRRV 144 Nocardioides sp....
AAT59594     77 -----sSSQVIIYTSFs-----sCTFPFae---gGEYLVFSSYrge------------gqLETSMCSGTKRLDe---AGA 128 Bacillus thuring...

Feature 1                   
1BQQ_T      114 QKKSLNHRYQMG 125 cow
XP_780837   144 QKKGIKNFYSAY 155 purple urchin
1UEA_B      112 QRRGFTKTYTVG 123 human
ZP_01051411 149 QLRILKRLKAKG 160 Cellulophaga sp. MED134
AAK58952    127 EKKLLGTFKCEN 138 dog hookworm
XP_873472   134 QRLGFQELYKNG 145 cattle
AAA96176    127 PKLEMKPTWKKF 138 nematode
ZP_01059139 127 QKRELDILKTFK 138 Flavobacterium sp. MED217
ZP_00657410 145 ERLLGEGHPATP 156 Nocardioides sp. JS614
AAT59594    129 DKVALSQIAKES 140 Bacillus thuringiensis serovar konkukian str. 97-27

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