1QWK


Conserved Protein Domain Family
AKR_AKR1G1_CeAKR

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cd19154: AKR_AKR1G1_CeAKR 
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Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins
CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Statistics
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PSSM-Id: 381380
Aligned: 8 rows
Threshold Bit Score: 486.149
Created: 17-Apr-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
active sitecatalytic
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Coptotermes gestroi aldo-keto reductase (5KET) binds its cofactor NADP.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         ###                       #    #                             # 
1QWK_A         5 TASIKLSNGVEMPVIGLGTWQss-paEVITAVKTAVKAGYRLIDTASVYqNEEAIGTAIKELLEEGv-vKREELFITTKA 82   Caenorhabditis...
NP_506205      5 VPIFTLSNGVLMPSIGLGTWQmt-geEGKTVIRNAVLAGYRHIDTATLYqNEHQIGDALAELFAEGi-lKREDIFITTKA 82   nematode
NP_509242      5 TASIKLSNGVEMPVIGLGTWQss-paEVITAVKTAVKAGYRLIDTASVYqNEEAIGTAIKELLEEGv-vKREELFITTKA 82  
XP_014665700   2 SIHIELSNGVKMPLIGLGTYEln-gnTGIEAVQVALQTGYRALDAAWLYnNQEEIGEAIANAVNTGv-vRREELFITTKV 79   Priapulus caud...
CBY37977       8 KSVFRCKSGFSIPAVGLGTYKln-gvSGVSAMKHAIKTGYKLLDTAFIYkNETEVGQAIAESVEEGvlkSREDIFVTSKL 86   Oikopleura dioica
OWF50467      22 ATNITLNNGIKMPLFGLGTWQsk-peDVKSAVRTALDTGYRLIDTAFNYqNEEAIGEVLKKYTETGk-vKREDLYITTKL 99   Yesso scallop
NP_504231      3 VDSIPLNTGAQLPLFGLGTWQvkdeaELTVALRAALDAGYRLIDTAHLYqNEHIIGKVLHEYISSGk-lKREDIFVTSKL 81   nematode
KHJ49402     327 SKCVTLHNGLRMPMVGYGTWQgk-gdALRAGLRKALEVGYRLIDTAYVYeNEDVIGEVLQQWLASGs-gKREDLFVTTKL 404  pig whipworm
Feature 1                                        #                                               
1QWK_A        83 Wth-eLAPGKLEGGLRESLKKLqLEYVDLYLAHMPAafndd------------------msehiASPVEDVWRQFDAVYK 143  Caenorhabditis...
NP_506205     83 Fch-eVAPDVVEEALRNSLKRLrLDYVDLYLAHIPAstkdd------------------gsfrsDVKVEDIWRGFEKVYG 143  nematode
NP_509242     83 Wth-eLAPGKLEGGLRESLKKLqLEYVDLYLAHMPAafndd------------------msehiASPVEDVWRQFDAVYK 143 
XP_014665700  80 SpqfyDSQESIKENCRYSLSKLrLQYVDLLLLHAPWavkkvegdts--------ptvngkcmtvPCDLAQVWKGMETCMD 151  Priapulus caud...
CBY37977      87 Hsg-fHKPSKILPAIRHSLNLMnSEYIDLYIIHAPWgmkpteaesgadfpfttatdetgndifdDYELVDVWAQLEKAVD 165  Oikopleura dioica
OWF50467     100 Gni-lTRPADVQYAMSESLRKLqVSYVDLFLIHIPLvlkkqadpynil-----pmkdgqldhdgAVDFEGVWKEMEKLVD 173  Yesso scallop
NP_504231     82 Pft-aHAPEDVPKCVESQLKALqLEYIDLYLIHCPFpfkhqegsfap-------lmengelavtEIAHIDTWRALEKLYK 153  nematode
KHJ49402     405 Amh-rHRRADVERSLRESLERFkLDYVDLFLVHAPLsakssdgrai--------dmvndhcipdVVDHLETWKGMEDVLS 475  pig whipworm
Feature 1                 ##                    #                         #######                
1QWK_A       144 AGLAKAVGVSNWNNDQISRALAlgLTPVHNSQVELHLYFpQHDHVDFCKKHnISVTSYATLGSPGRvnftlptgqk--ld 221  Caenorhabditis...
NP_506205    144 LGLTKAIGVSNFNESQIVRIMNiqKVPIHASQLELHLYLpQKAHRELCKKHnILITAYATLGSPGRmsvvgsngrplfes 223  nematode
NP_509242    144 AGLAKAVGVSNWNNDQISRALAlgLTPVHNSQVELHLYFpQHDHVDFCKKHnISVTSYATLGSPGRvnftlptgqk--ld 221 
XP_014665700 152 QGLTKAIGVSNFNSKQLQLVLDnaRIRPVVNQVECHIYQqQKKLQSFMAERgVVMISYGCLGSPGRnnpdksd------- 224  Priapulus caud...
CBY37977     166 EGLVRHIGLSNFDDDQVRLILSncRIKPVNNQIELHPWLdQPDSVQFLLDNdISVTSFMSLGRIERtldsk--------- 236  Oikopleura dioica
OWF50467     174 EGKTKNIGISNFNVAQVERIMKvaRVKPVVNQVECHAYFqQKELEAAMKKHdIVIMAYGSLGSPGSaaiitvpg------ 247  Yesso scallop
NP_504231    154 EGKLKALGVSNFSCNQLQALYDaaEVKPANQQVECHIYWpQQELRALCKKLgVTVTAYAPLGSPGRkaarpdg------- 226  nematode
KHJ49402     476 KGLTRSIGLSNFNIAQMTRIMDncTVKPHNVQVECHLYWpQFEIHEFCKQRnISLTGYSPLGSPGRashpvshig---vd 552  pig whipworm
Feature 1                                #              ######  #  ##                           #
1QWK_A       222 wapapsdLQDQNVLALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEvFDFSLTEEDIAKLEESKNSQRLFLQ 301  Caenorhabditis...
NP_506205    224 tqnseneMNDKHVKALAQKYSKTPAQILLRATVEMGIIVIPKTTNPERMKENINiFDFNISNAEVNLLEAHERTKQERLF 303  nematode
NP_509242    222 wapapsdLQDQNVLALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEvFDFSLTEEDIAKLEESKNSQRLFLQ 301 
XP_014665700 225 -iglqnmLEHSVVKSIGERHGKLPSQVCLRFLIQSGIAVIPKSATPARIKSNFDiCDFALNAAEMDSISEMHSGKRVFTF 303  Priapulus caud...
CBY37977     237 ---gktlVDEAIVLEIAKNHGKSPAQVLLRYQLQRGVLVIPKSATPSRIEENANiFDFSLSENDVLEISKLNKPLRSCHF 313  Oikopleura dioica
OWF50467     248 espppvlLQDPVLGEMAKKYKKTPAQILIRNLLQRKVIVIPKSVTPSRIQENGNvFDFKISSEDMATIAGIDKDLRMFKF 327  Yesso scallop
NP_504231    227 vwpegdpLLEPIVKQLAAKYHKTAAQILIRHLTQHGISTIPKSVSPDRIVENIStFDFKLSDEDMHTLNSIETRTRLFIA 306  nematode
KHJ49402     553 vskqrqpMDDPLAKQIATKHGKSVAQVLLKWLVQRGIVVIPMSTIASQIVSNLQlFDFTFDDAEMKALNAISYAVSSKYV 632  pig whipworm

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