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SICA C-terminal inner membrane domain The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies. The C-terminal domain is thought to remain in the erythrocyte, found juxtaposition to the single transmembrane domain. To date, all full length proteins contain a single copy of this domain. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",