2A07


Conserved Protein Domain Family
FH_FOXP2
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cd20065: FH_FOXP2 
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Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
FOXP2, also called CAG repeat protein 44, or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal, and cardiovascular tissues. An arginine-to-histidine missense mutation (R553H) in the FOXP2 Forkhead domain has been linked to a severe speech and language disorder. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410839
Aligned: 10 rows
Threshold Bit Score: 171.8
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingdimer interface
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2A07; Homo sapiens FOXP2 binds DNA through its Forkhead domain, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                             #  #   #  #  ##  #                         
2A07_F         2 VRPPFTYATLIRQAIMESsdRQLTLNEIYSWFTRTFAYFRRnaATWKNAVRHNLSLHkCFVRVEn-VKGAVWTVDEvEYQ 80  human
O15409       503 VRPPFTYATLIRQAIMESsdRQLTLNEIYSWFTRTFAYFRRnaATWKNAVRHNLSLHkCFVRVEn-VKGAVWTVDEvEYQ 581 human
Q4VYS1       494 VRPPFTYATLIRQAIMESsdRQLTLNEIYSWFTRTFAYFRRnaATWKNAVRHNLSLHkCFVRVEn-VKGAVWTVDEaEYQ 572 African clawed ...
NP_001303811 484 VRPPFTYATLIRQAIMESsdRQLTLNEIYSWFTRTFAYFRRnaATWKNAVRHNLSLHkCFVRVEn-VKGAVWTVDEvEYQ 562 coelacanth
XP_007892764 489 VRPPFTYATLIRQAIIESsdRQLTLNEIYNWFTRTFAYFRRnaATWKNAVRHNLSLHkCFVRVEn-VKGAVWTVDEiEYQ 567 elephant shark
NP_001025253 469 VRPPFTYATLIRQAIMESsdMQLTLNEIYSWFTRTFAYFRRnaATWKNAVRHNLSLHkCFVRVEn-VKGAVWTVDEmEYQ 547 zebrafish
AER14046     478 VRPPFTYATLIRQAIMESsdRQLTLNEIYSWFTRTFAYFRRnaATWKNAVRHNLSLHkCFVRVEn-VKGAVWTVDEvEYR 556 chicken
NP_001158441 488 VRPPFTYAALIRQSIIDSpdGQLTLNEIYNWFTRTFAYFRRnaATWKNAVRHNLSLHkCFVRVEn-VKGAVWTVDEmEYQ 566 Saccoglossus ko...
NP_001293724  79 VRPPYTYASLIRQAIMESsdCQLTLNEIYTWFTETFAYFRRnaATWKNAVRHNLSLHkCFQRVEqnVKGAVWTVDDsEFY 158 Caenorhabditis ...
ABB89487     478 VRPPFTYAALIRQGIIDApdRQLTLNEIYNWFTRTFAYFRRnaATWKNAVRHNLSLHkCFVRVEn-VKGAVWTVDEiEFM 556 purple sea urchin

Feature 1        ## 
2A07_F        81 KRR 83  human
O15409       582 KRR 584 human
Q4VYS1       573 KRR 575 African clawed frog
NP_001303811 563 KRR 565 coelacanth
XP_007892764 568 KRR 570 elephant shark
NP_001025253 548 KRR 550 zebrafish
AER14046     557 KRR 559 chicken
NP_001158441 567 KRR 569 Saccoglossus kowalevskii
NP_001293724 159 RRR 161 Caenorhabditis elegans
ABB89487     557 KRR 559 purple sea urchin

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