Conserved Protein Domain Family
AKR_unchar

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cd19101: AKR_unchar 
uncharacterized aldo-keto reductase (AKR) superfamily protein
This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Statistics
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PSSM-Id: 381327
Aligned: 36 rows
Threshold Bit Score: 351.897
Created: 24-May-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ###                                     #    #                           
PSP87659   10 EACRIINGYWQLSAKHnen--------qtsTPVEDTAEFVDAGLTTFDCADHYt---gVEELLGEFRNwyrre---hgtd 75  Halobacteriales ar...
OEJ73887    8 IPHSLIVGCWQLDDRSwtsi-------sepEIERAIDTYLALGLRCFDTADIYg---rSESLIGRLLKg----------- 66  Desertifilum sp. I...
PNR58272  121 RFAPLINGCWTLAGGHgrv--------vesEIIHVMEMYARSGLTSFDTADIYg---pSESILGAFREqwmnnkqendgl 189 Physcomitrella patens
PIB32708   11 TISRVIKGGWHLAGGHgni--------seeQALVDMRHFVKAGITTFDCADIYt---gVEELIGKFRKkykdqf-rsgel 78  Maribacter sp. 4G9
EIE18538   14 SISQVIKGCWQLSGGHggerds--drtsgnAAIEDFKPFVQAGITTFDTADIYg---pSESIIGEYLResg-------dr 81  Coccomyxa subellip...
PNW72043   35 NISRVVKGCWQLSGGHkgsret--drtsglAAVEDFGKFVAAGVTTFDAADHYg---pAEALIGRYLAsnpd-----qrp 104 Chlamydomonas rein...
KOO35341  335 RCPRLIVGGWQLSSGHskhpegsdldalrkRCHEHLAAHVAAGLVAFDLGDIYt---gVEVIVGRFVGehvar---grrr 408 Chrysochromulina s...
GAX23676   70 EISRTIQGHWQLAGGHgsf--------resDVLTNMKEHFDAGITTLDTADIYg---iSELIVGRFVKlq---------- 128 Fistulifera solaris
OUS48092   92 TPSRVIKGCWQLSGGHggdrds--drtkgdAAVEDFERFVEAGVTTFDTGPEAcgygpSELIIGEYLKspagr----rra 165 Ostreococcus tauri
EGB06911   16 PLPRVVIGCWQLLERDns----------rdAAVRTLEAYAAAGFTAFDTADIYg---pSESILGAFREah---------d 73  Aureococcus anopha...
Feature 1            #                                      ##                             ## 
PSP87659   76 lPVQIHTKIVPdrnrle-svsraYIEGIVDRSRRRLcvDALDLVQFHWWDYsvknYVDAARHLADLRDEGKIRHIGVTNF 154 Halobacteriales ar...
OEJ73887   67 rDCTIFTKAVFfgev----ptpsQVRNKIETSLRYLkqSSLDCVQVHWHNPql-dFSSTFETFNQLIEQGKIRTLGVTNF 141 Desertifilum sp. I...
PNR58272  190 rDVQIFTKFCPnifrm--kmtpqVVEQSIRRSIAALrvPKLDLVQMHWWDYdmpgMVDVAKSLAELREKGLITSIGVTNM 267 Physcomitrella patens
PIB32708   79 sPIQVHTKYVPdynala-tlkkeDTIRIIDRSLKRLgvEQLDLVQFAWWDYqfpkYLETAVHLSELQKSGKIRFLGVTNF 157 Maribacter sp. 4G9
EIE18538   82 gNVQVLTKFCCfgr------dmqTADSGVQNSLRSLgvDKLDLVQFYWHDYgvekYVGAAQRLAELQGAGLIRHVGVTNF 155 Coccomyxa subellip...
PNW72043  105 pKTQVLTKYCVfgqmdmatinkgAVVQAVNQSRKRLgvDSVDLMQYYWADYdvkrYVDGALYLSECAAEGLIKHVGVTNF 184 Chlamydomonas rein...
KOO35341  409 aSLLLHTKLVPdldelg-tygmaETRRAVERSCGRLqtSYLDLVQFHWWDLsvrrYVEVAQHLATLRRQGLVRELGLTNL 487 Chrysochromulina s...
GAX23676  129 pNAVPLTKFCCfryle--didraEVKRRIEKARERLqvDKLPLVQFFWSDYnvkrYVDVALYLTELKEQGLIQEIGATNF 206 Fistulifera solaris
OUS48092  166 nEVKVFTKLCCvgreqy-gmtkeWVEANVDRPRKRLgvDKLNMVQMYWNDYgskgYVDAALYLTDLKHKGKIDAVSLTNF 244 Ostreococcus tauri
EGB06911   74 gPLTFHTKYVTqds------skaNAVAVNKQSRKSLrvESLDLVQFHWWDFsdgaYVEAAKHLVDLRTKGFIGEVAACNF 147 Aureococcus anopha...
Feature 1                       #                            #######                          
PSP87659  155 DApRLEALLDaGVPVVSNQVQYSLLDTRPer-eMVDLCERrDMKLLCYGTLAGGFLTSKFAGepdpge-------atdle 226 Halobacteriales ar...
OEJ73887  142 NTpMLKQALQ-LAPIRYHQIQYSLIDRRVen-gMQQLCLDhDIGLLPYGPLAGGYLSDKFRGvqspp---------nqgs 210 Desertifilum sp. I...
PNR58272  268 STeALSQIIDaGVPVVCNQVQFSLLDQRPrm-aMLKYCKErDIKLFTYGTLAGGLLSNRYLEegkkglfgkvnyttpdln 346 Physcomitrella patens
PIB32708  158 DTkHIQEMLDaGVTIASNQVQYSVLDHRVek-nMTALAKEhNIPYLCYGTVAGGFLSDRYLNapdpv---------ppye 227 Maribacter sp. 4G9
EIE18538  156 DTpRLSEIVDaGVPVVSNQVQYSLLDRRPen-lMVPYCQEhGIKLLPYGTVAGGFLSERYLGlpask---------vrad 225 Coccomyxa subellip...
PNW72043  185 DVpRMEAMTKaGVRIAANQLQYSLLDRRPen-gMSAFCAAnNIQLLPYGVLAGGFLSDKYLGvpask---------vtsd 254 Chlamydomonas rein...
KOO35341  488 VLePTREIVQaGVPIATTQVQLSLLDRRVetsgLGAYCVAtGIQILPYGALAGGLLSDRWLGqpqppa------dplqhe 561 Chrysochromulina s...
GAX23676  207 DLiRLQELYEaGVPLVSHQVQLSALDRRAvqsgMANWCVDhNIGLIGFGTVGSGILSNEYLNrraptp-------eemne 279 Fistulifera solaris
OUS48092  245 DTqRMREMVDaGAEISTNQIQYSLLDRRPek-yMTKYCKDtGIGLLPYGVVAGGLLADKYLDapkge---------frin 314 Ostreococcus tauri
EGB06911  148 DAtHLETLLDaGVPLVANQVQYSLLDRRPen-gVIALATKrGLQLTCFGTAAGGWLSDKYLGapeptr------sdvskg 220 Aureococcus anopha...
Feature 1                                                  #                   ######   #  ## 
PSP87659  227 NRSLTKYKLIIEEVGGWEAYQNLLGTVSDIADKHg-------VSIANVATRYVLEk---PRVGSAIVGARN-TRHIESNQ 295 Halobacteriales ar...
OEJ73887  211 HARGFYYSSMVRAHGGWSPVLALLEDLATVGSKYn-------LTIAQVALNWVLQq---PGVAGVISGVTLdRRQMQKNV 280 Desertifilum sp. I...
PNR58272  347 TSSLKMYWRVVREAGGEGHWRKLLSTLGEIAASKe-------VSIASVALRWAMQ----QGPVHPIVGLRN-STHLDDNL 414 Physcomitrella patens
PIB32708  228 NRSLTKYRLIIDEFGGYELFQEALQVLRTIADQYq-------VGIAEVACNYILQk---QMVGGIIVGARN-RNHLESLQ 296 Maribacter sp. 4G9
EIE18538  226 TYSKSKYASVISQSGGWDWFQSLLRELDGVARKHg-------ADIATVSSRWVLDq---PQVAGVIVGARN-ARHVAQHQ 294 Coccomyxa subellip...
PNW72043  255 TYSKGKYARVIMEAGGWSWFQDLLQALDGVARKHd-------VTISNVAARWVLDr---PGVAAVILGARN-ADHVEDNQ 323 Chlamydomonas rein...
KOO35341  562 SRSLTKYLLIVDEAGGWGALQALLRALRAIADDAtaavggepLAIADVALAWARSr---PGVGGVIVGARG-IGRIQQMV 637 Chrysochromulina s...
GAX23676  280 TASMRMYSRTAARFGDWKLVQELLGTMDEIAKQVrldgrcstANISNIAQRYVLEt---PAVVSVLIGVRN-LEHLDENV 355 Fistulifera solaris
OUS48092  315 TSSLRKYSSVLAEVGGFEWYQSLLKTLRAVGDKHg------gASISNVASKWVLDs---PVVPAIIIGARN-ASHIDDHR 384 Ostreococcus tauri
EGB06911  221 TVSLRMYKSSLDAWGPWSLFQDLLKTLRAVGDELd-------ASISAVAVAWVLDaldrSCGGSVILGVRD-ASHLDDHV 292 Aureococcus anopha...
Feature 1                        
PSP87659  296 RTLAFELDDEDHRTIEVAR 314 Halobacteriales archaeon QS_4_66_20
OEJ73887  281 EAMHSAIAPEDIAQLTARS 299 Desertifilum sp. IPPAS B-1220
PNR58272  415 TALSFSLEPAEMDKIEEVL 433 Physcomitrella patens
PIB32708  297 KLDSFTLNQNDLVKIESIV 315 Maribacter sp. 4G9
EIE18538  295 KLFEFKLDGEDRGRIDAVL 313 Coccomyxa subellipsoidea C-169
PNW72043  324 RLFSFRLDADDLGAIDEVL 342 Chlamydomonas reinhardtii
KOO35341  638 RAASRTLPAELLARATAAA 656 Chrysochromulina sp. CCMP291
GAX23676  356 KTHSFRLKAEEKAAIDQVV 374 Fistulifera solaris
OUS48092  385 ALFDFDLDDSDRRDIESVL 403 Ostreococcus tauri
EGB06911  293 RARDLALDDMHRAAIRAVL 311 Aureococcus anophagefferens

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