Conserved Protein Domain Family
DDE_3

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pfam13358: DDE_3 
DDE superfamily endonuclease
This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.
Statistics
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PSSM-Id: 433142
Aligned: 30 rows
Threshold Bit Score: 93.891
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8ZSE8          20 RTISIDEmTGIQATErLEKDLPMRPGKV--ERREFEYIRHGTQSLIASFDVATGQIVePTCSDTRTEIDFAL-HIRRTIE 96  Nostoc sp. PC...
Q01P88         181 PVVCLDE-KPVTLHAdVRPTSPAKPGRE--ARRDNEYERRGTANVFCAVEPKAGRHF-TFATPDRSAFEFAH-VVFELAM 255 Candidatus So...
jgi:Pnap_4724   30 PVVCMDE-TPRQLIReTREPIAAAPGRP--ERHDYEYERCGVCNVFMASEPLAGRRL-TKVTERRTKTDWAV-FVQDIAA 104
jgi:Veis_3846  180 PVVCFDE-SPTQLIGeVRQPIPAEPGQP--LRYDYEYKRNGTANLFVFLDAHRSWRR-VKVTERRMAQDFAQ-CMRDLVD 254
XP_001959946   322 RVVFHDE-RRFNLDG-PDGFSYYFHDLRnyERTLSQRPRGNSVYIYLMVCVGG-----AVHLEVSSAKQRPEsCIEAIMR 394
Q12BS7         169 QIYWGDE-MGLRSDH-VSGKSYAPAGQT--PL-IRATGQRFGCNMISAITNKGALAF-MVFEGKFRAPLFVE-FLRRLLK 241 Polaromonas s...
WP_011733788   171 EIYWGDE-TGIQTGA-NVERGYSPKGKT--PV-LRQTGRKHRINMISAITNQGKVRF-MFYKETMNSKRLIT-FMKRLVK 243 Pelobacter pr...
jgi:Tmz1t_2354 172 VIYWADE-TAVKEDT-NWIRGFAPAGRT--PV-LEASARWAKLSMISAITNRGEIAF-QIVEGTINAERFIE-FLERLIA 244
ADD07678       179 TVVCIDQ-TKKSVQV-EPRAAWFPRGTR--PS-VELSGQRDWTCLLGAITENGDRFF-TRFEEYVTAAHAKH-FILALCQ 251
Q5V1W0          25 TVVVVDQ-FTKHVGT-VQRRGFYPIGSN--PT-IEVATSWDSVTVLGAVTDNGDSFF-CWTEENLTRNHGIR-LLEALKD 97  Haloarcula ma...
Q8ZSE8          97 TDTQAk----KWHLIMDCLN--THQSESLVRLVAEKeglnldlgikgesgilksmksrttflsdpAHRIVFHYTPKHSSW 170 Nostoc sp. PC...
Q01P88         256 QYQQAd----TIHLVLDNLN--IHCLKSLTDAFGMEmgc------------------------evWDRFTIHFTPKHGSW 305 Candidatus So...
jgi:Pnap_4724  105 SYPDAe----RITLVMDNLN--THTPGSLYEAFSPEqak------------------------alWDRFEFVYTPKHGSW 154
jgi:Veis_3846  255 IHYPQa---eRIRLVLDNLS--THTAAALYQSMPPQear------------------------riLQRIEFHYTPKHASW 305
XP_001959946   395 ERPNIvgklgSPEFVLQDHNwmSHALPTAQDLLNA-------------------------------EGLKTQKWPTIAHD 443
Q12BS7         242 QVEG------KICLIVDGHP--VHKSGVVKRFVQAN-----------------------------AQRLRLILLPGYCPE 284 Polaromonas s...
WP_011733788   244 DAGR------KVYLILDNLK--VHHSHVVMDWLEKH-----------------------------KDKIEVFYLPSYSPE 286 Pelobacter pr...
jgi:Tmz1t_2354 245 SAAS------KVFLIVDNLR--VHHAKLVQAWVETR-----------------------------RAQIELFYLPPYAPE 287
ADD07678       252 EFED------NLIVVLDGAP--YFQASAVTDLAAR-------------------------------DDLTFVRLPAYSPE 292
Q5V1W0          98 RFGE------ELVVFLDRAG--YFYARDLWEHVSGEretetvgd--------------ssvscvrGDDLEVWYFPSKLPE 155 Haloarcula ma...
Q8ZSE8         171 LNQIEIWFSILVRKLLR-RASFLSQDDLK 198 Nostoc sp. PCC 7120
Q01P88         306 LNQAEIEIGLFSRQCLG-KRRIPTLISLR 333 Candidatus Solibacter usitatus Ellin6076
jgi:Pnap_4724  155 LNMAEIEINVMVDQCLS--RRIDSIETVR 181
jgi:Veis_3846  306 LNMVEIEIGVLRRQCLD--RRIDCRERLI 332
XP_001959946   444 LNIMENVWGWLIREVFDgGRKFSRKDDLI 472
Q12BS7         285 LNPDELLNQDVKTNALG-KSRPANKSEMI 312 Polaromonas sp. JS666
WP_011733788   287 LNPDEYLNNSLKGRVHS-GERAQNVKQLE 314 Pelobacter propionicus
jgi:Tmz1t_2354 288 SNPDEYLNHDFKTALRL-EPPSRDDSQLL 315
ADD07678       293 LNPVEECWRQLQAALSN--RFFDSLPELT 319
Q5V1W0         156 LNAVEGCWDQLQEWFKY--RLVPDISSLK 182 Haloarcula marismortui
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