Conserved Protein Domain Family
RSD-2

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pfam07547: RSD-2 
RSD-2 N-terminal domain
This domain is found in three copies in the N-terminus of the C. elegans RSD-2 protein. RSD-2 (RNAi spreading defective) is involved in systemic RNAi. Mutations in the rsd-2 gene do not effect somatic genes but only germline expressed genes.
Statistics
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PSSM-Id: 400093
Aligned: 17 rows
Threshold Bit Score: 86.59
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q93845         96 FSSVPHHLTFNRKVAYADWYGLVDSSGI-------EIKFAGVFGVMIA-------------VNDL-DYELTGQHLFK-VV 153  Caenorhabditi...
2_pfamImport    1 FSDDPAHKTFDLNLAFADWYGSVDSSAFkdqillySSGKKRVFNSLII-------------VNDL-KYKENGTQLFK-VH 65  
O62256         96 FSSDPSHLTYDRNIGYADWYGPVNCSQFk-----aKNTKVAFFKYLIA-------------VNDL-DYKNTGECLMK-AV 155  Caenorhabditi...
Q9XUE3        227 CSSIETHITYPQSVAFADTFGKVNVAAE-------SMERGVTYRVELA-------------INII-DSEANNVPLFK-IS 284  Caenorhabditi...
XP_002634186  127 FSVESNHPTYSKKKAYAGVFGHVEVDENva----lRMERNQVYKAELT-------------FNNStELSQKSTYGFK-VW 188 
XP_003088181   92 FSFLDTHPTYSKKKVYAGGFGHVEIEDHls----eKMDRGIVYKVELS-------------LNVL-EIKDNQKPVFK-VT 152 
6_pfamImport    1 FSNNNLHATYTKNVAFSNQFGHVEISKAd-----eSLDHLVLYETFIT-------------LK---QCEDTALPVFEaIS 59  
3_pfamImport    1 FSNNNGYKTYNRSCGFSNRFGLVEIADPa-----dGLLGNTVYSTNIE-------------IK---QWLDPLEPVFRsVS 59  
4_pfamImport    1 FSSNQKHGSYNKTVAFSDSYGLVRIPESn-----aSLKHMAVYNTLIQllvlfnlniqsdkVRFRcQNEDKLKPIFIsVG 75  
Q9XUE3         44 FGDNPNYLTYNRDLGYADWYGIVDCSDS-------PPTGPGVYKAFIY-------------VNDL-NYQESGNPLFKvTG 102  Caenorhabditi...
Q93845        154 QRPWKLKSTADt-SEFWQKLLQFEE 177  Caenorhabditis elegans
2_pfamImport   66 ELGFPIVGKDAevDEFLQNMNSHEK 90  
O62256        156 QLVGVIDNRDA--AEVRLKMMEFER 178  Caenorhabditis elegans
Q9XUE3        285 DIGEKLTGEEN--EAFLRKLNDFEE 307  Caenorhabditis elegans
XP_002634186  189 SICGDASPEES--EAFMTSLYLYED 211 
XP_003088181  153 KVYELLESEDG--EAFLNELYEFDE 175 
6_pfamImport   60 TLQN--KSDQSqiEDMIKYMEEYE- 81  
3_pfamImport   60 KLK---EEDVEfsDDFANSMVQFEE 81  
4_pfamImport   76 PLK---QDENDpnARFIESMYNYED 97  
Q9XUE3        103 RLKFLANKDTS---DTMMKLEIFEQ 124  Caenorhabditis elegans
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