Conserved Protein Domain Family
Xre_MbcA_ParS_C
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pfam09722: Xre_MbcA_ParS_C 
Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain
This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp.. This domain interacts with the toxin component and sterically blocks its active site, neutralising its effect. These antitoxins also have a HTH domain at the N-terminal.
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Statistics
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PSSM-Id: 462855
Aligned: 165 rows
Threshold Bit Score: 38.2704
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q120Z5           126 QAQRIVdnsTSeqaegfdtAHWLGQ-WLE-QPQPA--LNGLRPSDLLD-T--ETGTQMVHQLLGAMESG 187 Polaromonas sp. JS666
WP_013449813      64 DLQTLY---GS--------PEAVRA-WMK-TPAPV--FGDQTAWEMIRlE--PQGLEAVEAYVENLKEG 115 Oceanithermus profundus
CCO60818          82 VLRTVF---NN--------PEL-VYgFMT-SQNHNtfFEGRAPIDVIE-GgnFGSLYDVYHRVNALRGG 136
jgi:Q7C_1533      78 SLQILL---PD--------QVL-ADqWLA-TPNDNplFNGTAPLDRIL-AgqVVDLAVVRDFLDAERGG 132
Q21PX8            94 ALHIIY---GD--------KL--ADeWVS-LPNKNaiFAGRTPLQYML-SggLIGMQTVRKLLDARRGG 147 Rhodoferax ferrireduce...
jgi:Deipr_2413    91 ALRILF---VG--------EA--SKaWLT-RPNGRrtLNGQRPLDYML-SggIPAMLTVRQLLDADRSG 144
jgi:Plav_2369     97 alGILF---PD--------ERS-GVeWLT-TSHGAlpFGGRPPLDLLT-SgsQDGLLSVRRFLDGARGG 151
QianUST:TMO_0842   7 RVEAWA---GG--------PRAALS-WYRaYPIPA--LGNRTAESLVK----TGGASAVRDYLDHVAlg 57 
Q5LL86            63 kVEPRF---GS--------ELMAYA-WYRsEPLPG--FDGRTAMQLVQ----EGKVQQVLDYVDAVDAG 113 Ruegeria pomeroyi
Q7NH13            69 AAAMIG---GE--------ANRAVI-WFRfEPLPG--FDHKTAAQLVA----EGHADAVETYLDMLDDG 119 Gloeobacter violaceus
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