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bifunctional allantoicase/(S)-ureidoglycine aminohydrolase, UGLYAH2 family The UGLYAH2 family acts primarily as allantoicase (allantoate amidinohydrolase, EC 3.5.3.4), while unrelated to the AllC family of allantoicase enzymes. It belongs to a broader family of enzymes with (S)-ureidoglycine aminohydrolase activity (EC 3.5.3.26) carried out at the same active site. However, Puggioni, et al. consider that activity secondary, as (S)-ureidoglycine is an unstable compound expected only as a product of allantoate amidohydrolase (AAH) activity, and AAH is nearly always absent when UGLYAH2 is present. UGLYAH2 is an acronym for (S)-ureidoglycine aminohydrolase type 2. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",