Conserved Protein Domain Family
F420_Rv2161c
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TIGR03619: F420_Rv2161c 
probable F420-dependent oxidoreductase, Rv2161c family
Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity]
Links
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Statistics
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PSSM-Id: 274680
Aligned: 31 rows
Threshold Bit Score: 213.273
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_011593597  67 TEVAQTAENNGFESLWVYERSLYPLTpeepYPYSdpPGGDWPSyyrQTADPLSVLAAAAMVTSHVRLGTSVLIAAQHIPF 146 Rhodococcus jostii
WP_011604452  30 gELAVAAEAAGFHGFAFTEHPIPGAR------WLasGGHQS-------LDPFVALSAAAAVTTRLRLLTYLAVVPYRNPF 96  Frankia alni
WP_011603606  25 TPWVRAVEESGWSGIAFTDHPAPS------TKWThaGGEGSS-------EPFSSLAFCAALTEDITLITLVTVLPYRNPL 91  Frankia alni
WP_011604572  25 AEVGRLVEEAGFDAVSMSEHPIPDD------AWLgnGGHHAF-------DPFVSLSFLAAATTRLRVMTYVAVAGYRSPY 91  Frankia alni
WP_011730112  25 vavaaaaeaagFDGFGFTDHPAPS------QRWLdaGGHDA-------VDPFVAMAYAAAQTTTLRLVPNIVVLPYRNPF 91  Mycobacterium s...
WP_011728665  28 VAIAQAADETGFDFLTCSEHVAIP------RADAarRGAVYW-------DPLSTLGFLAAHTRRIRLATAVLVLSYHHPL 94  Mycobacterium s...
WP_011604931  25 TGFARAAEESGFAALGFSDHPAPSAR------WVdsGGEGS-------ADPLVSLAFCAAVTSRIRLFTWALVAPYRSPL 91  Frankia alni
WP_011606550  43 TRVVQAAERLGYAAVAFTEHPAPS------TKWLrsGGHEALD---VVP----ALAFCAAATTRLRLMTYLLVLPYRNPL 109 Frankia alni
WP_011557718  30 RTVAQAADSLGFEYLTCSEHVAVPA------ADAlaRGAVYW-------DPLATLGFLAACTSRIRLATSVIVLGYHHPL 96  Mycobacterium
WP_011605097  17 ariarriEEAGYDAIAVNDHLAPS------RKWYeaGGHDA-------YEPFGLMAYLAAVTERVRLMTFAVVVPHRNPF 83  Frankia alni

WP_011593597 147 QLAKTIATIDQISEGRFVAGFGAGWSKDEIRAAGADPKFRGRYLDETLDVLAAAWGPDPVSYQGRRTIVNNAIVAPKPAS 226 Rhodococcus jostii
WP_011604452  97 LLAKSAATLDKISHGRLTLGVGTGYLKAEFFALGVDFDERNELFDEALEVLPLHWKGEPFSYQGKHFTARDVIARPRPVQ 176 Frankia alni
WP_011603606  92 FTAHQIRTLDRLSGGRLVVGVGTGYLRGEFRASGADFDRRRELFDEALEILTADTDIEEISHRGIGFETSGTALRPPSIQ 171 Frankia alni
WP_011604572  92 LLAKSAASLDRLSGGRLTLGVAAGYLKTEFAALGADFTQRGRLLDAAIPAMRAVWTGRSVDRDDPTFPLHGHTSLPTPAQ 171 Frankia alni
WP_011730112  92 VVAKSGATLDLLSGGRFTLAVGVGYLKREFAALGVAFDERTELFDESLEVIRGIWTTDDFTYEGMHFSARGITAHPRPVN 171 Mycobacterium s...
WP_011728665  95 ELVKRYGTLDRLSCGRLVLGVGIGSLREEFDLIGAPWEKRGARADDAIRALRASMGRAEPAYEGPFYAFSEMTVLPHAER 174 Mycobacterium s...
WP_011604931  92 LTAHQVATLDALSAGRLTLTLGAGYLRSEFGALGVDFDGRLAAFDETVDVLRASWEQPRLTHSGALLQTRGTNIQPRVVQ 171 Frankia alni
WP_011606550 110 LTARAAATVDILSAGRLTVVVGTGYLRSEFRALGVDFDERNLLFDEALEVLRGVWSRSPFDYEGRHFTAASIASLPMPVT 189 Frankia alni
WP_011557718  97 EIAKRYGTLDRVSGGRLTLGVGVGSLAAEFELLGAQFGDRGRRADDALRALRASLSTTRPAYDGEFYQYDSVVVEPCAAQ 176 Mycobacterium
WP_011605097  84 ALAKSVATTDALSDGRLDLGVAVGYLRSEFLALGADFDERNELFDEALAVLRGAWTASSVSARGRHFDGLDQVLAPAPVQ 163 Frankia alni

WP_011593597 227 Rv--PVLIGGGGtPRTIERIASRADGWlsIPFGs-------------KG--------------F--------------QE 263 Rhodococcus jostii
WP_011604452 177 Dp-iPIWIGGNS-KLTLRRVAQKVQGW--MPLG--------------GP--------------AelftttrtaqlattEA 224 Frankia alni
WP_011603606 172 RphpPLWVHANS-RWGLERAARFGGGA--LFTLttetlagtirtahvPD--------------A--------------AA 220 Frankia alni
WP_011604572 172 AggpPIWIGGNS-NAARRRAVTLADGW--MPMGqsvevakitktppmAD--------------V--------------AA 220 Frankia alni
WP_011730112 172 Pp--PIWIGGNT-AAARARVARHGDGW--CPFA--------------AP--------------PglaqtagtaaidsiER 218 Mycobacterium s...
WP_011728665 175 Id-vPIWVGGRT-EASLRRAVSLGDGW--MPFG--------------L-------------------------------- 204 Mycobacterium s...
WP_011604931 172 QphpPLWLHGNS-AWGRERAVRYGQGV--VTLLtndtlartirtaavPG--------------V--------------DG 220 Frankia alni
WP_011606550 190 PggpPIWVGGNS-AVARR-RAARVQGW--SPLM--------------IPdaiagttrtpalttF--------------AQ 237 Frankia alni
WP_011557718 177 Pr-vPIWVGGRT-RRSLRRAVELADGW--MPFG--------------LS--------------A--------------DR 210 Mycobacterium
WP_011605097 164 LphpPLWIAGNS-ARARRRAAAWGQGW--APLSiddlgartirsvsiPT--------------V--------------DD 212 Frankia alni

WP_011593597 264 IESTWNKIRERAVELGRSAEHLEHIV------CanitltselagaeRT--PFVGTLDQIVEDVVAASKVGVDELIIDL 333 Rhodococcus jostii
WP_011604452 225 MAAKIRELRDLAGERASQLDIAPAYL------D-------------ATinRPDHEADRHREAFQTLADAGVTNLIISa 283 Frankia alni
WP_011603606 221 VGERIDRLRDATTAAGRDPQEVTVVL------Ggvl-------sliDV--RQGWNTEQVRAEVAAYERLGVDWLIFNV 283 Frankia alni
WP_011604572 221 LAEAVRGVQDRRAEAGAAPLDVSFVP------Yea---------elLP--DVDAFARAVAASYRAYEDAGVTWITIEP 281 Frankia alni
WP_011730112 219 LAAGIADLRAKLDAAQRDPSTVDIVF------Tnfd-------ggnPG--DDDFDADAYLAGVDQLAALGVTWLHVTI 281 Mycobacterium sme...
WP_011728665 205 ---RTSGIRALLDAT-PTPDGFEVVL------Stg----------hAV--DPIGDPAGTRKRLSGLADAGATVASCTI 260 Mycobacterium sme...
WP_011604931 221 FTRVVDDVRARLDAAGRPRDAVDVVA------Tgmw-------pqlDA--RQGWDAAAMLDDVATYAKLGADWIVIAV 283 Frankia alni
WP_011606550 238 LRSAVTEVNELASRERGRDVTVDVQLqslqstW-------------LQ--DPNGSPDEHLNFLGQARDAGATWFVVQP 300 Frankia alni
WP_011557718 211 LSELLSTV--------DVPADFDIVLp----vA-------------PL--DPSGDRDRAARRLRALDDLGATAVTCTL 261 Mycobacterium
WP_011605097 213 LRRAARTLRADTVVAGRDPAEVGLWA------Ttsd-------saaAG--RDELDPGAHLDHLVELAELGASHFTTTf 275 Frankia alni
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