Conserved Protein Domain Family
ASKHA_NBD_YND1-like
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cd24039: ASKHA_NBD_YND1-like 
nucleotide-binding domain (NBD) of yeast nucleoside diphosphatase 1 (YND1) and similar proteins
YND1 (EC 3.6.1.5), also called Golgi apyrase, ATP-diphosphatase, ATP-diphosphohydrolase, adenosine diphosphatase, ADPase, or Golgi nucleoside diphosphatase, catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. YND1 is required for Golgi glycosylation and cell wall integrity.
Links
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Statistics
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PSSM-Id: 466889
Aligned: 11 rows
Threshold Bit Score: 447.572
Created: 25-Jan-2023
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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Feature 1: catalytic site [active site], 1 residue position
Conserved feature residue pattern:EClick to see conserved feature residue pattern help
Evidence:
  • Comment:The catalytic residue Glu functions as a general base to deprotonate a water nucleophile for direct attack of the terminal phosphate group.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
P40009        8 DRFGIVIDAGSSGSRIHVFKWqdtesllhatnqDSQSILQSVPHIHqe-------------------------------- 55   Saccharomyces c...
CAE85507      3 GRWGVILDAGSSGTRLHIYRWkdpek---alvdATPEELRSLPKITtk-------------------------------- 47   Neurospora crassa
Q9USP2        3 RKYGIFIDAGSSGSRLLIYSWdyd------tdsSLSDKVKKLPLIEtgig------------------------------ 46   Schizosaccharom...
KAB8342774  577 DKYGVVLDAGSSGTRVHIYKWdnpli---arekASEKELHALPEISth-------------------------------- 621  Carpinus fangiana
CCF54738     96 RKYAVLIDAGSSGSRMQVYSWkdpkle-ralraKQGLDATVLPKVEkgtwe----------------------------- 145  Ustilago hordei
KIY30801     10 THYALVIDAGSSGSRLQIYSWrdp-------dlERAEILQDVKNIErggsssssaggerwwwggedgwkgkgkgkgkeme 82   Cryptococcus ga...
TIC05019      8 RNYAIIIDAGSSGSRSQIYSWdn--------siATEAHAPELPYVElglgra---------------------------- 51   Wallemia mellicola
OAJ37553    250 RCYAVVIDAGSSGSRVLIYSWk----------dPRLPSKKNIITIEkgse------------------------------ 289  Batrachochytriu...
CEI87921     17 RKYGVIIDAGSSGSRVYIYSWkdheh--aksafTIDELKGKIPVVErady------------------------------ 64   Rhizopus micros...
POW22008     20 RQFGIVLDAGSSGTRIQVYSWksprvq-lkqrvTSRQSTKVLPRIEtgvq------------------------------ 68   Puccinia striif...
KNE62295     69 TQYAIVIDAGSSGSRVQVFSLqp--------skHGLPEFGRAMHPTlh-------------------------------- 108  Allomyces macro...

Feature 1                                                                                       
P40009       56 ----------------kdWTFKLNPGLSSFekkpqDAYKSHIKPLLDFAKNIIPeshwssCPVFIQATAGMRLLPqdIQS 119  Saccharomyces c...
CAE85507     48 ----------------kkWTKKIRPGISTFgekagVVGQDYLKELIDHALDIIPadkihdTPIFLMATAGMRLLPqvQQN 111  Neurospora crassa
Q9USP2       47 --------------dggkWSLKVQPGISSFannpkHVGKKHLKELLDFAAHAIPkdvhkeTPVFLSATAGMRLLGvdAQN 112  Schizosaccharom...
KAB8342774  622 ----------------krWTKKVKPGISTFadhpsSVGPDHLKALFDHALEYIPeqdvpdTPIFLLATAGMRLLPdmQRN 685  Carpinus fangiana
CCF54738    146 -------------nsgmdWSLKVTPGLSSFgd-rpADVGKYLKGLLDHAEKIVPpsawadTPIYVMATAGMRLLPkqQRE 211  Ustilago hordei
KIY30801     83 evalrrlvrvgkgvegddWVKRVEPGISTVd---pENVPEYLAPLLTHALQYIPpsvhssTPIYVLATAGMRLLPpqQRD 159  Cryptococcus ga...
TIC05019     52 ------------vagdkpSGWKVEPGISTLep-svNELEVYLRQLLEPALNIIPpsarqnTPVYVLATAGMRLLNldRQK 118  Wallemia mellicola
OAJ37553    290 --------------lgplPQLKTSPGISSFak-hpQKVANHIRSLLDFAASVVPidkhksTPIFLFATAGMRLLSsqDQQ 354  Batrachochytriu...
CEI87921     65 --------------nglkWTSREEPGISTYgs-kpSEVGEHLDMLLNFAKEVVPeenqssTPIFLMATAGMRLLPqdQQD 129  Rhizopus micros...
POW22008     69 --------------dgndWQLKVEPGISSFgs-hpHHLGEYLKPLLDHALKLIPskqiatTPFYLLATAGMRLLPqsQQD 133  Puccinia striif...
KNE62295    109 -----------------dWQLKTEPGVSSFad-hpHDVSSSLAPLLKFAMGIVParlhesTPLRVLATAGMRLLPlhKQT 170  Allomyces macro...

Feature 1                                             #                                         
P40009      120 SILDGLCQGLKhpaeFLVEDcs------aQIQVIdGETEGLYGWLGLNYLYGHFndynpe-------------------- 173  Saccharomyces c...
CAE85507    112 AITGAVCTYLRkntnFSLPDcd------lHIQVIpGETEGLYGWIASNYLLGGFdhpeqha------------------- 166  Neurospora crassa
Q9USP2      113 KILSHACRYIKknydFDIPNcs------nSIRVIdGKAEGMYGWLATNYLLKTLeek----------------------- 163  Schizosaccharom...
KAB8342774  686 EILRQVCDYATrttkFQLPDce------lHVQVIpGDTEGLYGWIAANYLLNGFdnpeehq------------------- 740  Carpinus fangiana
CCF54738    212 AVLAEACRYIRqhtsFSIDGggc----deHVQVItGEEEGLLGWISINYLMDGFhirgkkpsla---------------- 271  Ustilago hordei
KIY30801    160 AILQATCDTLHndypFLVPGptedgpcgeNVRVIdGEEEGIWGWVAVNYLMDGFghaplpsslsnpgtyssystnllpla 239  Cryptococcus ga...
TIC05019    119 AIVNAADAALErivgYDTDTe-------lKMRVItGEEEGFFGWLAVNYLMDGFvskrk--------------------- 170  Wallemia mellicola
OAJ37553    355 LLLKISCTYARlhynFLLPEsc-----isYFQVIsGELEGIFGWLTVNYLKGTFdskpdsnpvaghd------------- 416  Batrachochytriu...
CEI87921    130 ALLKSTCDYIHthsrFFMSNce------tHVRIIsGELEGVYGWVAVNYLMGGFdtsikayidq---------------- 187  Rhizopus micros...
POW22008    134 GILEEVCSYIKknyrFRIKEcn------qHIQIIsGEEEGTFGWVAVNYLMDGFdpatshss------------------ 189  Puccinia striif...
KNE62295    171 AVVDAVCNVLRny-pFAAAPsgc----heTVRVIsGEDEGLFGWLALNYLTRSFhda----------------------- 222  Allomyces macro...

Feature 1                                                                                       
P40009      174 -------------------vsdhfTFGFMDMGGASTQIAFAPhdsgeiarhrddi----------atiflrsvngdlQKW 224  Saccharomyces c...
CAE85507    167 ------------------hgqdhhTYGFLDMGGASAQIAFAPnsteaqkhandl-----------kllrlrtldgspAEY 217  Neurospora crassa
Q9USP2      164 ---------------------dtsTVGFLDMGGASVQIAFELppsqlknykdsi-----------stvhiglqngqqLEY 211  Schizosaccharom...
KAB8342774  741 ------------------hgnghhTYGFLDMGGASAQIAFAPnateaekhandl-----------kllrmrtldgnpLEF 791  Carpinus fangiana
CCF54738    272 --------------getdimegksTFGFLDMGGASTQIAFEPskkalqgegaaaea-------eltpvslrmldgteVSH 330  Ustilago hordei
KIY30801    240 plasappdsssasitpvdiahhspTFGFLDMGGASTQLAFSPsaselltsgfppdk--------lrtvslrllsgeqVDW 311  Cryptococcus ga...
TIC05019    171 -------------------pgsqhTWGFLDMGGASTQIAFEPkrgwgdgipreidd-------glidfklrmtdgsyRDY 224  Wallemia mellicola
OAJ37553    417 ------------snavsiakhikpLFGFLDMGGASAQIAFSPtaymakehsddl-----------ktvqirfldgleTTY 473  Batrachochytriu...
CEI87921    188 --------------qpkkpeeqhhTFGFLDMGGASAQIAFEPehhqkeehrddl-----------tqvtlrtldgrtVEY 242  Rhizopus micros...
POW22008    190 -----------------kgassssTFGFLDMGGASTQIAFEPnelakiehadnl-----------tkltlrlldgtvISH 241  Puccinia striif...
KNE62295    223 ---------------------krkPLGFLDMGGASTQIAFSVpaaaaaavsadpeetrtthpapyqvvhvptaqgavRPF 281  Allomyces macro...

Feature 1                                                                                       
P40009      225 DVFVSTWLGfGANQARRRYLAQLINTLpentndye-------------------------------nddfstrnLNDPCM 273  Saccharomyces c...
CAE85507    218 KVFTTTWLGfGVNRAREAYVQSLSDLYttsd----------------------------------------ageLPDPCL 257  Neurospora crassa
Q9USP2      212 PLFVTTWLGfGANEAYRRYLGLLIESEngkv----------------------------------------gntLSDPCS 251  Schizosaccharom...
KAB8342774  792 RLFTTTWLGfGVNEARRRYIKALIDGAgag------------------------------------------keLPDPCL 829  Carpinus fangiana
CCF54738    331 KVFVTTFLGyGTNQARQRYIDLLRSIDgnsqn--------------------------------------skhaLPDPCL 372  Ustilago hordei
KIY30801    312 PVFVASWLGfGTNRARERYITSLYQQWasahpsps--------------------------------aqdlatpIPDPCL 359  Cryptococcus ga...
TIC05019    225 TVFVATWLGyGTNKARDRHVSHLLQLAqseanyksyekpaedvsq-----------dddddglqipdnsssrltIDDPCL 293  Wallemia mellicola
OAJ37553    474 SLFVSTFLGfGVNEARKRYEESFIKPSettteslktayrkqstaptsaydlshtnienfkihardmlnkrdelvFDDPCL 553  Batrachochytriu...
CEI87921    243 DVFVTTFLGyGSNEARRRYLEKRVEEVfaevngkeqqk--------------------------hlldehhllhLQDPCL 296  Rhizopus micros...
POW22008    242 SVFVTTWLGyGTNKARERYAQQLLEQYtldhhqtr--------------------------------epsqhevIPDPCL 289  Puccinia striif...
KNE62295    282 AVHVTTFLGmGTNEARKTHVRELAAKAssdsdss---------------------------------psnaeplIADPCL 328  Allomyces macro...

Feature 1                                                                                       
P40009      274 PRGSStdfefkdtifhiagsgnyeqctksiyp---------lllknmpcddepclfngvhapridfaNDKFIGTSEYWYT 344  Saccharomyces c...
CAE85507    258 PKGLRlsldgtpvskpkkgettligtgafdeclrk---typllgkdkpcaddpclingqhvpaidfdVNHFVGVSEYWHT 334  Neurospora crassa
Q9USP2      252 LRGRTydidgiefagtgdlkqclkltynll-------------nkdkpcsmdpcnfdgisippvdfaNTEFVGVSEFWYT 318  Schizosaccharom...
KAB8342774  830 PSGLEvaqsdshiiqssrfipsephllgtgkfteclsatypllekdvacedepclfagshvpaidfeINHFVGISEYWHT 909  Carpinus fangiana
CCF54738    373 PSGLQlsdvegkpdvaltgtgnftaclesmhp---------lldkeaactkppclfhgvhvpkidfsVNHFIGVSEYWFS 443  Ustilago hordei
KIY30801    360 PNNLSvppplssssqpaligtgsftecltslhpl-----lehstpcptshclfagqptphidferhdQRGFIGISEYWYT 434  Cryptococcus ga...
TIC05019    294 PLNLDvvdphtdnfihgtgsfpgclralepl-----------lereafcahppclfggqrvppidfqLDRFVGVSEYWFS 362  Wallemia mellicola
OAJ37553    554 PLGLKvssshstdlstifngsgsyddcmarih--------pllnkdiqcaelpclfngvhapiadfrNHHFIGVSEFWYT 625  Batrachochytriu...
CEI87921    297 PLNLNltdshstsiplflhgtgdfnecikyte--------pllnkdaacptqpclfngvhtphidwsVNKFVGISEYWYS 368  Rhizopus micros...
POW22008    290 PISLLlpssstnyqfngtgdfrqciqnvspl-----------lnknvpcldepclfdgkhvppidfsVNRFIGISEYWYS 358  Puccinia striif...
KNE62295    329 APGLEltehldaddhgvarsvtlagrgsydsc--------raltdaqlhhehscapnsgaclvradlNQTFVGVSEYWYS 400  Allomyces macro...

Feature 1                                                                                       
P40009      345 ANDvfklg---geynFDKFSKSLREFCNSNWtqilansdk--------gvynsipenFLKDACFKGNWVLNILHEGfdmp 413  Saccharomyces c...
CAE85507    335 THGvfggke-neaydFTTYQKRVKDFCGRDWnsiepsld----------ahkkfavkDAQEACFKASWLINILHEGigvp 403  Neurospora crassa
Q9USP2      319 TNDvfdmg---gsyhFPNFYKKVDEYCGTEWetmlsrlynk-------eltpstdenKLEKLCFKASWALNVLHEGfdvp 388  Schizosaccharom...
KAB8342774  910 THEifemghadaaydFQTYQARVTEFCSKPWkdlqhsislk-------kygrkvdeaTAAEVCFKASWLINMLHEGigip 982  Carpinus fangiana
CCF54738    444 AQDvfglg---gvydFVDFQKAANEFCSKPWaklkhhldag------dlfgpevqlnRLQTQCFKAAWMVTVLHEGigip 514  Ustilago hordei
KIY30801    435 MQHvlgvg---gvwdWGEWEKGMKEFCGKEWgvikgevedg------dreglnmdptRLEMQCFKGAWISNVLHEGigip 505  Cryptococcus ga...
TIC05019    363 SEHvfglg---gawdLVRFERAAEEYCSRDWnvlteeweaghvsgvsgkwgdqidlpRLRMQCFKASWIVQVLHSGigip 439  Wallemia mellicola
OAJ37553    626 LFDvyelg---geydYQRLLDASRSYCSTSWktilakheqt-------pypnvedmdRLQFQCFKSAWIMSVLHDGlglp 695  Batrachochytriu...
CEI87921    369 THDilglg---gvydFTEYEEKATQYCSKDWsaiieehk----------dvsqmelnRYQMQCFKSAWIVNVLHEGiqip 435  Rhizopus micros...
POW22008    359 TQDlwsmg---giydFVEFEKKAISYCQLNWeeiieshksg------tkwpsnievsRLETQCFKAAWIINILHEGigip 429  Puccinia striif...
KNE62295    401 TYDmlglg---gayvPEVFSAHTRAFCAQPWdspahraa----------aaagvaesRLQAQCFKAAWIASVLHVGfgip 467  Allomyces macro...

Feature 1                                                                                       
P40009      414 ridvd--------------------------------------------------------aenvndrplFQSVEKVEER 437  Saccharomyces c...
CAE85507    404 rigveelpapgln----------------------------------------askgaietakqkgfldpFHPVDKIDGI 443  Neurospora crassa
Q9USP2      389 ksntssnda------------------------------------------------kdglsvipayhspFTSLEKIERT 420  Schizosaccharom...
KAB8342774  983 rvgieaskhvadsq--------------------------------------natkeildsakqqgylapFQAVNKIDKT 1024 Carpinus fangiana
CCF54738    515 rivdhkgagdgt-------------------------------------------dhadeaqgkgeqknlFQSVNDIDGF 551  Ustilago hordei
KIY30801    506 rlvdvggndtltggslgdt----------------------------nveaerrarekglfegkeqgkqhFQSMDQVGET 557  Cryptococcus ga...
TIC05019    440 rivdpggnitnsedps----------------------------------vkgkemaeqkglarpddepvFQSVNSVDSV 485  Wallemia mellicola
OAJ37553    696 kiipgntdt-------------------------------------------------tgesdqanhfpvFQSINEIDDF 726  Batrachochytriu...
CEI87921    436 rinnpsghlnltede-------------------------------------qlleqvkqsvesknwhplFQSIDTINDI 478  Rhizopus micros...
POW22008    430 riidkggqgdrtdynq----------------------------------egiqkaaqkgllnspsappnFQSLNEVGNI 475  Puccinia striif...
KNE62295    468 eaalpssstetvgpapsvcpvaeksilgpahvqvpppahvkahetlfrspaapttpavtvngscvrpeihVLTSDHVGDM 547  Allomyces macro...

Feature 1                    
P40009      438 ELSWTLGRILLYA 450  Saccharomyces cerevisiae S288C
CAE85507    444 EVSWTLGKMVLYA 456  Neurospora crassa
Q9USP2      421 EVSWTLGQVLLYA 433  Schizosaccharomyces pombe 972h-
KAB8342774 1025 EVSWTLGKMLLLE 1037 Carpinus fangiana
CCF54738    552 SVSWTLGKAVLEA 564  Ustilago hordei
KIY30801    558 AISWTLGKVVIEA 570  Cryptococcus gattii E566
TIC05019    486 PISWTLGSVLLTA 498  Wallemia mellicola
OAJ37553    727 PISWTLGAVLLYA 739  Batrachochytrium dendrobatidis JEL423
CEI87921    479 QVSWTLGAMLLHV 491  Rhizopus microsporus
POW22008    476 TVSWTLGKMVLEI 488  Puccinia striiformis
KNE62295    548 QVTWTLGSLLYDR 560  Allomyces macrogynus ATCC 38327

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