Conserved Protein Domain Family
LldD

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COG1304: LldD 
FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase [Energy production and conversion, Lipid transport and metabolism, General function prediction only]
FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Statistics
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PSSM-Id: 440915
Aligned: 763 rows
Threshold Bit Score: 108.296
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_072623402   1 Mstlqsgpgrrrqda--------lyrpgalgiaptvP-----T-RAEEleAR------ALATMSrragaYIAGGAGGGAT 60 
WP_012422434   1 Md--------------------------------------------tE--FMgiepniLNNKKR-----QIEICLNKE-D 28 
WP_083457982   1 MacdhkansrsdtststrasvtvralrstvevrlgnVattsgIeSARE--LI------STRKDH-----HLDLCLRADVG 67 
WP_024269203   1 Mnnqth-------------------------khhseIssdqhSgDSAE--QM------GSRKAA-----HINICTDETYP 42 
NP_212818      1 ---------------------------------------------------MgiepniLENKKR-----HIEICLNKN-D 23 
WP_045100775   1 Mq------------------------------------------DDYS--QF------EKRKQD-----HIELALMQANQ 25 
YP_096067      1 Mq------------------------------------------NEYS--QF------EQRKRD-----HIELALMPANQ 25 
WP_114592679   1 Maadhvhragpgp-----------------qpqgpaagpglaLsEQAD--AS------ARRKAD-----HLRVVLDGDVA 50 
WP_011164104   1 Md------------------------------------------ESNS--QF------EKRKRD-----HIRIALDPRSQ 25 
WP_102243449   1 Mq--------------------------------------------------------ETRKRD-----HIELTAKSQTN 19 
WP_072623402  61 MRSNREAFDRWRVVPRML-H-A-TTTRDLSTTLL----GTELTAPLLLAPVGAAGlVTDDADLLIAQGAHASGVPYVFSC 133
WP_012422434  29 VSKSDNLLNFVNLKHDALsElD-FYEIDTSESIF----GYDIAMPIFISSMTGGIqEGNKLNKSLVKIANNLRIPMGLGS 103
WP_083457982  68 SRGPATGLGGWTLEYDALpEvD-LEDVDLSVTLF----GKKLRAPILVGAMTGGTdRAGLVNRRLARAAARCGLGMALGS 142
WP_024269203  43 VEGGNSAFSGVKFIHSSLpElD-YDQIDSSCDFL----GFRLSAPVMISCMTGGSdQGYRLNKILAEAAQKKKVAVGTGS 117
NP_212818     24 VKGGCNFLKFIKLKHNALsDfN-FSEINIKEEIF----GYNISMPVFISSMTGGSkEGNDFNKSLVRIANYLKIPIGLGS 98 
WP_045100775  26 -ASELNVLDSFTLIHEALpDlD-FVEINIASQRF----GKQVAKPFFVSSMTAGHrGSVNINRNLVEACAKSNWAMGVGS 99 
YP_096067     26 -SSELNPFDHFSLVHEALpDlD-FKDISIQSIRF----KKPVEKPFIISSMTAGHsNALEINYRLMEACSKTKWAMGVGS 99 
WP_114592679  51 HVGLTTGLEGVRLAARALpGhD-LDTVDLSVRAF----GTTLGAPVLISCMTGGTgDAGPVNAALAAAAQHHRVALGLGS 125
WP_011164104  26 -TDGQNGLDSITLIHEALpDlN-FKEVDISTSFFfsgeSIPLSSPIFISSMTAGHeKGREINEALARLSDRRQILMGVGS 103
WP_102243449  20 -----GLLVDSRFYYEPLlSaHpTQETDISTTFL----GKKIQAPFWVSSMTGGVgEARHINQNLARVCREFSLGMGLGS 90 
WP_072623402 134 QGC--------SPMEETAQAmagtP--F-WY------QLY--WSTDEELVDSMIGRAETAGAQALVVTLDTTmlgwrtqd 194
WP_012422434 104 FKLifkypeyiKYFA-LRKCa---DniP-LFsnigaiQLRe-----FG-IFKVIEIIKKLEVDAIIVHLNSG-------- 164
WP_083457982 143 QRAmivrpelgATFD-VRASa---PelPlLIanvgavQLNy----gVG-TSEIRSAIERVGADAIDVHLNAL-------- 205
WP_024269203 118 LRIllrkpeviDHFR-LKEMa---PdvP-VIgnigavQLPemMADDKALLRQFYDILRELKLDALAVHLNPG-------- 184
NP_212818     99 FKLlfkypeyiRDFT-LKRYa---HniP-LFanvgavQIVe-----FG-ISKIAEMIKRLEVDAIIVHLNAG-------- 159
WP_045100775 100 QRReltdnqaaSEWYSLRRDf---PgvS-LFsnlgitQLIq-----AP-LTQVQSLIEALQAEALIIHCNPL-------- 161
YP_096067    100 QRReltdkqaaFEWTPLRRDf---PmvS-LFsnlgiaQLId-----TP-ISAIQRLIDTLQAEALIIHCNPL-------- 161
WP_114592679 126 GRVllqg-gdpaSFE-VRDIa---PdvP-LLanlgavQLAe-----VG-LDGCHELVERTRADALVLHLNAV-------- 185
WP_011164104 104 QRReledsnaaEEWARVRKQa---PkaR-LLgnigiaQLIk-----SP-IDKIRRLIDSTEAVALFVHLNPL-------- 165
WP_102243449  91 CRTllesgqyfEDFN-LRPIl--gNdlP-FFanlgiaQVErlVHD-QE-INKIFDLINRLDTDGLIIHVNPL-------- 156
WP_072623402 195 lDLGSLPfargqgiaQytsdprfmelvrerlaagaraaqslgidprrplqaAraakggvatllsmsrehpggvrdnlrsp 274
WP_012422434 165 -QELMNS--------R-----------------------------------G---------------------------- 172
WP_083457982 206 -QEAIQP--------E-----------------------------------G---------------------------- 213
WP_024269203 185 -QELFQE--------G-----------------------------------G---------------------------- 192
NP_212818    160 -QELMKV--------D-----------------------------------G---------------------------- 167
WP_045100775 162 -QEVIQP--------E-----------------------------------G---------------------------- 169
YP_096067    162 -QECIQP--------E-----------------------------------G---------------------------- 169
WP_114592679 186 -QEAVQP--------E-----------------------------------G---------------------------- 193
WP_011164104 166 -QEALQP--------E-----------------------------------G---------------------------- 173
WP_102243449 157 -QEWFQP--------E-----------------------------------G---------------------------- 164
WP_072623402 275 epraavetflDIYSNpaLSWEHIATLRERT---RLPVVLKGI---LHEDDARRAFDCGVDAVVVSNHGGR---QVD---- 341
WP_012422434 173 ----------DRNFK--GIKDSIARLCDAS---NLPVIVKETgfgISPGCVISLLDLGVSYVDLAGSGGTnwvLVEgike 237
WP_083457982 214 ----------DTRFK--GLIARLEGTLPEL---GVPAIAKEVgagISERAARKIARLPFAGVEVAGTGGTswaRVEshra 278
WP_024269203 193 ----------DRNFR--NILASIRELCAWS---ELPVIVKETgagIPPAEAAALFASGVRYVDIAGSGGTnwlSVEafre 257
NP_212818    168 ----------DRNFK--GIRESIAKLSDFL---SVPLIVKETgfgISPKDVKELFSLGASYVDLAGSGGTnwiLVEgmks 232
WP_045100775 170 ----------TPQFK--GCWHALANIVKIL---PVPVIVKETgcgFSLETLKRLNNIGIAAVDVSGLGGThwgRIEghra 234
YP_096067    170 ----------TTNFQ--GCWTALEALVKKI---ASPVIIKETgcgFSKNTLLRLNNIGVAAVEISGVGGThwgRIEghra 234
WP_114592679 194 ----------DTGFG--DVLGRIADVVAGL---GVPVVAKEVgfgMAADDVRALVDTGVAAIDVAGAGGTnwaRVEghrd 258
WP_011164104 174 ----------TTDFK--NGLAAIENLVKLA---GVPVIVKETgcgFSVDTLKRLSSTGIYGVDVSGKGGThwgRVEgyrs 238
WP_102243449 165 ----------DKFLF--SPIETIAKLSEAFkgsGKKIIVKEVgqgMGPKSLKSLLDLPIDAIELAGFGGTnfsQLEylrt 232
WP_072623402 342 R-----------------------SIAALDALVRVREAV-----Gp---E---PT------LLMDSGVRSGAD---LFVA 378
WP_012422434 238 Enlnvas------------cfsnwGISSVLTLLSIKDS------F----K---DR------IFASGGYETGID---IAKG 283
WP_083457982 279 Paasmqaev--------gerlagfGVSTAESVRICRRA------Lg---Da--RT------VIASGGVRHGMD---VAVA 330
WP_024269203 258 EhdrrlqgrdhqpiprelhgfedwGIPSAPGLSALSSYCrkrglVp--sN---GG------IISSGGLRDPMD---YPRA 323
NP_212818    233 Nnlnias------------cfsdwGIPSVFTLLSIDDS------L----K---AN------IFASGGYETGMD---IAKG 278
WP_045100775 235 Gegsvkqkt--------astfrnwGIDTVQTVIDAVSL------Np---R---FE------VWGSGGVRNGLD---AAKL 285
YP_096067    235 Nkdpirqrt--------adtfrnwGIDTLQSTRNAISL------Np---S---FE------IWGSGGVRNGLD---AAKL 285
WP_114592679 259 Tdagaia-----------aafvdwGWSTHDSLVAAMGV------Lg---D---APadrrplLIASGGLAHGVD---AVKC 312
WP_011164104 239 Eesdmlyhv--------aqtfanwGISTKQSMLNAIDA------Rv---E---YQ------LWASGGVRNGLE---IGKL 289
WP_102243449 233 Kgadklei----------ealakvGHTSLEMISILNNL------LkanpDyikKQ------IIISGGIGNFLDgfyLQEQ 290
WP_072623402 379 LALGADACLLGRPHVYGLALDGEAGVSAVIDNVLAELDLTMGLVGAATVDDITRELLV 436
WP_012422434 284 IALGAKLVGIASAILRAFYAGGEDALYKLLKDYEYVLKMSMLLSNSKNLVQFRLNKYF 341
WP_083457982 331 IALGADAAALAKPLLAAADE-SEDAVVRVLETLIFELKVIAFCCGARDVAELRAVRAI 387
WP_024269203 324 LALGGDLAAAALPFIRLARSGGAAAVESYLDEIFLTLRRTMLLTGSATIHELKQAPLL 381
NP_212818    279 IALGARLIGVAAVVLRAFYDSGEDAVFGLFSDYEHILKMSMFLSGSKSLLEFRNNKYF 336
WP_045100775 286 IALGATSIGFAKPMLDAALE-RASSVYDLMQLIEYELKVAMFCTGSRVLSELKEKACR 342
YP_096067    286 FALGATTVGFAKPMLEAALG-STGQVLTQMNTIEYELKTAMFCTGSRVLDDLKEKACP 342
WP_114592679 313 LCLGADLVGFGRRLIAAGAE-GPERATSALGTLVQQMRIAVWGIGATRPSDLGTAHLA 369
WP_011164104 290 MALGASKVGVAKPFLEAALQ-GDEALEKLLTQLETELKVTMFCTGSRNLKDLQSKKVI 346
WP_102243449 291 LHF-SSIIGQAKNFLTRSE--NYEELKAFTNAQIEGLKMARKFLTIK-TSEVQ----- 339
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