Conserved Protein Domain Family
Med2

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pfam11214: Med2 
Mediator complex subunit 2
This family of mediator complex subunit 2 proteins is conserved in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with and phosphorylates Med2. Post-translational modifications of Mediator subunits are important for regulation of gene expression.
Statistics
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PSSM-Id: 402683
Aligned: 21 rows
Threshold Bit Score: 101.617
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGW33686       6 LQTKLDASLNDILKTSGYIF--EVLNNNKKQSNLLTGPNNQLitpqiIAQLSHQMLKFDDILDETITKFNDARWCIDQMV 83 
XP_001645812  14 GKNKLVECFEDILEVSSQMLvqQQLKSIQLDNSVISGFNQGQ-----QKVLLEKVTLFHSILDDLEITLNKGKNYVDELT 88 
XP_003683937  28 YRNKVTQCFDDILDVSTQMLvqQQLKTIQLDINVTNGFNLSQ-----QKILHEKVNLFHSLLDDLECTLETSKTFTEHIA 102
XP_003668128  47 KTNKLTQCFDDILKLSTEMMvqQQLKTIQLDSNLINGFNENQ-----QNSLKEKINSFHGILDDLEISINKSLTYLDTIS 121
CCC67574      14 PKNKLTQCFDDILKISSEMLlqQQLKTIQLDSKVSNGFNASQ-----QRSLKEKINLFHGILDDLEISIAKSFDYVDTIV 88 
CCK72512       3 EQNKLTRCFDDILRLSSEMLvqQQLKTIQLDT--VNGFTQDH-----QKVLSEKIHSFHGILDEVDVTLLNAVRFVEKFD 75 
Q757M0        21 RGDRLTQCLDDIMRASTEMMvqQQLKTIQLNSDVAAGFRKAL-----SKSLGDRVRAFHSILDGVETTLTTASQYLDAVE 95  Eremothecium go...
XP_003646867  12 NTDRLTQCLDDIMRAATEMMvqQQLKTIQLNSDVAAGFRKNF-----SKSLGDKVRLFHSILDGVDTTLTTASQYLETVD 86 
XP_003681203  22 hRNRLTECFDDIMKVAAEMMvqQQLKTVQLDSAVVNGFSQAQ-----QRVLSEKIHMFHAILDDLQTTLTKSKSYVGTIH 96 
XP_002494556  20 HENKLTQCFDDIMRVAVEMMlhQQLKTVQLDSSVVNGFSHNQ-----QRMLSEKIHIFHAILDDMETTLGKSKDYVEAIY 94 
EGW33686      84 ENKQRQEEMKIRE----EQERARRlkEEEE 109
XP_001645812  89 KIGKDKEEERERVrraeEEKKRLL--EEEE 116
XP_003683937 103 KLGKQREEEKL------KKDKERE--EELE 124
XP_003668128 122 KISIEKRKENIKTkilkEQEEKEK--EKQl 149
CCC67574      89 EISNEKli--------kKKELQRK--EEEA 108
CCK72512      76 AVSKEKELERVKQr---EREAQIT--AEEE 100
Q757M0        96 EAAVKMKQWKQQQ----EEEQRRK--HQAE 119 Eremothecium gossypii ATCC 10895
XP_003646867  87 DVAHRMKQWKLRQ----EEELRRK--QQEE 110
XP_003681203  97 EIALEKQKVKEKEr---ADLRKRQ--EEEE 121
XP_002494556  95 ELGREKELQKEREr---EELRRRQ--EEEE 119
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