Conserved Protein Domain Family
COG3886

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COG3886: COG3886 
HKD family nuclease [Replication, recombination and repair]
Statistics
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PSSM-Id: 443094
Aligned: 151 rows
Threshold Bit Score: 168.624
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ADB39422        5 VILPYFIDLNNkVPtnsTDRMQTKFFTND-----DSnSLLAKIEGIFKHrNihFFDALVGYFYASGYFRIRPYIERAAEv 79  
NP_208290       1 -------------------MSSVQILSNL--------NYPKVITEGLRNsL--NTHIAVAFLKYSGVEVIQDTLIDSLE- 50  
WP_014269529   13 NLHSGFIDASV-PS---SGNYGPHLVLNDp---pRT-KVLATLLQELDQcT--SFVFSVAFITSGGLAMIFQSLCDAQK- 81  
WP_014773439    1 --------------------MRVEFLGHGlhkdhTN-TVGHYMIDSFKNdDyySFVGFSAFTKMSGINRIKEELLEASK- 58  
WP_014824824   11 SLHKGFINQSK-AA---SSQFKPKLLSNk----aHE-NVLSSLLQEMKTcK--TFTFSVAFITEGGLATIKTMLYDLQK- 78  
WP_016356593   11 SLHKGFIDSSA-TM---LETYKPELLINNre--kNE-TVLATLLDELENcN--TFIFSVAFITESGLASLKAHLLNLKS- 80  
WP_083470389    1 ---------------------MSKFLSQPl----SL-QFGEYLKQELNNlDwkLLEIGVAWVRRSGVRHIFNDLAAFLE- 53  
WP_068759585    1 ------------------MEQETVFIRNq----gGV-TVLSDLLQSLDQcE--GFCFTVAFMTFGGVQLLVQKLSELEQ- 54  
WP_120176842  103 ALAASFVDGDV-DS---DPGLRAEFLSNDpk--aGT-KVVSVLEEELARcD--RFAMSVAFVTMGGLTPLLETLRELRD- 172 
WP_079535444   35 SLESSFIGSCF-EP---DERYAPHIVSNDsd--kKD-DVLSVIKREINDcV--SFDFSVAFITDSGIQVLAQVFSELKK- 104 
ADB39422       80 RvlvginvdkmvfeaskqgvlfsadayksqedffeSAKKNIQQAKYSKAVEDGMLGMID-DIVSg-kLQIRVHp------ 151 
NP_208290      51 K----------------------------------GAEFEIIVGLDFKTTDSKSIRFLL-DLNKty-kKLRFYcygdken 94  
WP_014269529   82 R----------------------------------GVKGKILTSDYLNFTDPKAIRDLWkKFPN---IEVRVYs------ 118 
WP_014773439   59 K----------------------------------FQSLKFYLGIVRKGTSREALQFLI-DNn----IETWIFct----- 94  
WP_014824824   79 K----------------------------------GIRGRILTSTFLSFNQPKMFKELL-KLTN---VEVRVTd------ 114 
WP_016356593   81 K----------------------------------GISGRILTSYYLSFNNPKVFKELM-KLDN---VEVRLTd------ 116 
WP_083470389   54 R----------------------------------GGEIKCIVGVDFEHTTLEGVQDLM-LLKEhgkFILYVYhn----- 93  
WP_068759585   55 R----------------------------------GIYGRVLTSTYQQFSEPKAIEKLQ-SFKN---IEVRLYdq----- 91  
WP_120176842  173 R----------------------------------NVPGRILTTDYLLFSEPRAIEHVLnEFPN---IEIRLYrtf---- 211 
WP_079535444  105 R----------------------------------GIPGRILTSTYQMFNTPDALRKLL-EYPN---IESRIFn------ 140 
ADB39422      152 ---KQNIHAKVYVFREqvrhdHGYGSVITGSSNLTEPGLERNFEFNVELRENGD---IDFATETFERLWSES--VPVSEE 223 
NP_208290      95 nktDIVFHPKIYMFDN-----GKEKTSIIGSTNLTKGGLENNFEVNTIFTEKKPl-yYTQLNAIYNSIKYAD--SLFTPN 166 
WP_014269529  119 ---GKPFHTKGYLFYHg---eEEYASMVIGSSNLTQEALATNREWNVRLVSLQQgdlLVKTQEEFNNAWSLS--VPVSEA 190 
WP_014773439   95 -edQIMFHPKIYFFQG-----KHNYRFITGSSNLTSFGLFENIEASTFFEFSKTnqqGKKLVRQFEEYFE----PILNGT 164 
WP_014824824  115 ---VKGFHSKGYIFEH-----DQHYSLIVGSSNLTDSALKANFEWNVYLTSLENgevIHHFKNQFEQQWNIA--MPLNDE 184 
WP_016356593  117 ---SPGFHAKGYLFDN-----GEYSSVIIGSSNLTMNALKVNYEWNIKLTSHENgeiVKSLNQQISTLWEES--IELTEE 186 
WP_083470389   94 -eaSSVFHPKCYLFSN-----NEYAKLIVGSNNFVEAGLYTNIEASLEITEQSSdpaIVEAKKSFEFWCDTTnnLAFELD 167 
WP_068759585   92 -viEGGLHAKGYLFMK-----GELVEVYIGSSNLTTSALKENIEWNVKLTKSKSdvmVEDVLSDYELLWEAA--GSLTKE 163 
WP_120176842  212 -gsSAGFHTKGYMFES-----GTGCRLIVGSSNLTQTALTTNREWNARLVSRTKgafAAKMLAEFEALWHHP--ASRPAR 283 
WP_079535444  141 ----GDLHSKGYFFDR-----REISTIIIGSSNLTQAALTCNKEWNVLFKSFPGgkiLEESKKEFKKLWASP--EAIKLT 209 
ADB39422      224 --FITRlksetflndqftpyEVYLKFLIEYFGKSIDYDPNSETDLPKGFLPLVYQRDAVNDGYNKMEKHGGFFLSDVVGL 301 
NP_208290     167 eeYLQNynevfsaiikneqkvskdksiqekikeiekqekllpgtipsikamivefifacekkgvkqvalqdiyqaleeri 246 
WP_014269529  191 --WLTHye-----------kLYKNVHVHTPYVPVFADDFLPGEEADINGITPNSMQSEALKSLASLRAKGKTKALLISAT 257 
WP_014773439  165 dn-----------------nVQKLTQEVLKDLEDSGFIWPESKTNAEYEFVKSNKKAFAKRKKSKFDKGSLGKIESKPPS 227 
WP_014824824  185 --WIAQy-------------QINYEKPEFKNKVASPPLYITNPLKESLKIQPNKMQTAALEQLNLLRQSGANRGLIISAT 249 
WP_016356593  187 --WISKyelmyt---pivntKKVDQLNYQPKKITYKELAELEEEECSEYSISDKEYFIKPNKMQKKALKSIEEVRNNGEN 261 
WP_083470389  168 epFFNAlv----------enGYLKSETDLKSFLSSYRGSSTSNESPTATQNRLFGRKNYSAPRVSRQSDSVENIEEVFSE 237 
WP_068759585  164 --KLEKykasyqrfkaferesllevedalllpsevrpnlmqqaamkrlnslrqrgekkalviaattath----------- 230 
WP_120176842  284 s-ELPSyrea-------wekAREVRRRLTEVAEEAEVTEIPEGASDADARPVESSHESFFGTSVPASAQESPSASTETES 355 
WP_079535444  210 ssWIDSyeeafl--elksfrSSSLDAQRKAQKEISGISENKRAISKQNKDSDPFLGCSIKPNKMQSQALEALEVLHSRNA 287 
ADB39422      302 GKTIIATRIAKKFYFKNGFPEHRSRTLIVVPPALKVNWEETIEKFSLDGVHIITNGSLHKVRNPNQYDLIIVDEAHKFRS 381 
NP_208290     247 kkksgdtntkaillgtlsgansttmc------------------------------------------------------ 272 
WP_014269529  258 GTGKTFLCAFDVKAYRPGRFLYIVHREQIASESMKSFKQIVGTDASYGFLGGGESERDCHYVFSMIQTLSKDEVLHSFPP 337 
WP_014773439  228 NNNDSDYIPVITQDYLNSWPDFFELFKEFKKENKDKGDKYSVVVPRDYKNPSLYNWYLKQKIYFKNKTLPPEHEELLKKE 307 
WP_014824824  250 GTGKTYLSAFDVRNAAPKRMLFVVHREQILKKAMHDFRNILLGDPQDYGILSGNSKDLNARYLFATVQTISRDPYLQQFA 329 
WP_016356593  262 KALVISATGTGKTYLSAFDVRDFKPKRMLFIVHREQILRKAKSDFQKIIGGSEEDFGILSGNSKNTSAKYLFATIHTISK 341 
WP_083470389  238 ASNQDSDENVNSAEEQAPTGTTPSLRGRNLYMRVRKAHESRLTQTQIPKRLLQDMFFEDLNEIISGHDGEVHRVSVAHAR 317 
WP_068759585      --------------------------------------------------------------------------------     
WP_120176842  356 ERAPGAVSEPSDELPADRLAPVPATTPGSNPSVPEHGSESDVATLVAAVNRPRTRFPALRPNRMQRDFVASVLKLVRDGE 435 
WP_079535444  288 SRALLISATGTGKTYLSALDVFLTKPKKVLFVAHRARILRDSMNSFKNVLEDRYSYGMYGGSNKEKSSSCVFAMVGTLQS 367 
ADB39422      382 DTAEAYNDLQKICKTPTRRRRQDGTAYPKRVMLVSATPLNNYPQDIANLVYLFQDSKDSTLEIGNLQHFFRQHIDAYRRL 461 
NP_208290         --------------------------------------------------------------------------------     
WP_014269529  338 GWFDYIVVDEVHRSGGQSYQKVLDYFKPKFLLGMTATPERTDGFDIYALFDNTIAYEIRLNQALEADLLCPFHYFGISDL 417 
WP_014773439  308 HFYFGDAHKLWQEWKDSTKLKLLQEAVDEGENIGLSQRYEYKGVRLGTWIQGIKKANKSGKKLDVMEKINEIFDLSSKSR 387 
WP_014824824  330 KDHFDYILIDEVHRAGAESYLKIMNYFKPQFLLGMTATPERTDNFNIYELFDYNVAYEIRLQAALEEEMLCPFHYFGVTD 409 
WP_016356593  342 DSTLKEFSAETFDYILIDEVHKAGANSYLKVLDYFTPNFLLGMTATPERTDNFNIYDLFNYNIAYEIRLQEALEEDMLCP 421 
WP_083470389  318 GAINTMKLEVPEMRDFEDPVMEFRHTDDGLIYNVYDSSTLQGQRIRRILDEGLSSSPPTTFSTLPSDLSRATLWRFI--- 394 
WP_068759585      --------------------------------------------------------------------------------     
WP_120176842  436 RRALLISATGTGKTYASAFAVRALLGKFEADAPHSPHCRAPRVLFLVHREQIARQARESYRRVLGSGVSSGLYTGAVSRA 515 
WP_079535444  368 HLMDFKPDEFDCIIVDEAHRVGAAGYQKIIEYFTPKFLLGMTATPNRTDGYDVYQLFNHVIAYRITLQDALDNDMLTPFH 447 
ADB39422      462 KQEPDMQKVNAGVRQIYEQIRVKVIEPLTVRRTRTDLKLHHQYRDDLTAQKIEFPDVRKPEKILYQLAPHLEALYDQTIR 541 
NP_208290         --------------------------------------------------------------------------------     
WP_014269529  418 TIEGKPFEDFSTFSRLEMDEWVKRVQQTIDRYSIGLKRRRGLIFCSRNDDAVILSEKLNILGFRTLALSGKDDIESRNDA 497 
WP_014773439  388 TPVDTANRFINDLLEAENPEKASFQNRFNHSIRDRIDELPDEVQQDIVDVWFLVFEEERPLGRIRTRQKDRTDEWKAFRY 467 
WP_014824824  410 YELDGELIDETADLQKLVHRERIDHIIEKISYYGFSGDRVRGLMFCSTKEEARTLSNLLTMRGYKTTALTGDHSQEEREE 489 
WP_016356593  422 FHYFGVTDYVYEGKKDDDTSVLSKIAPEEHVNHIIEKIAYYGFSGDKVRGLIFCSRTSEAVELSSLLNERGFRTTSLIGA 501 
WP_083470389      --------------------------------------------------------------------------------     
WP_068759585      --------------------------------------------------------------------------------     
WP_120176842  516 EREEAIDARIVFATVQTMEKACRTEEDEGTLFDDVRDVRDFAPESFDLIVIDEVHRAAAASYLRIMRYFEPRFWLGMTAS 595 
WP_079535444  448 YFGIADLEIDENNVEDVSLFRKLTSKERVRHITEKIEEYSVRKESRKGLIFCSRNDEAKTLSAEFNKLGYKTRAISGETS 527 
ADB39422      542 HLTHPTEGLTYNRYRAIGALKPHKKQKYKKADMISTQLAKIMKTMLVKRIDSSFFAFRQSIRRFCEANEAMVKMFDTGRV 621 
NP_208290         --------------------------------------------------------------------------------     
WP_014269529  498 FRRLEIEDGPESLEYLIAVDIFNEGIDIPSLNQVILLRPTESAIIFVQQIGRGLRKCKGKEFLTIIDIIGNYTNNYMIPI 577 
WP_014773439  468 NNAINPEGVWFSTYSAMGDLYSWVRQKREVKSRMDLVKKNFNEQEKSELRREGFPI------------------------ 523 
WP_014824824  490 AIAKLENGELEYILTVDIFNEGIDIPFINQIVMLRQTQSSIIFIQQLGRGLRKHNVKEYVTIIDFIGNYKNNYLIPIALS 569 
WP_016356593  502 DLPEHREEKITELESGQLDYIITVDIFNEGIDIPSVNQVIMLRQTKSSIIFIQQLGRGLRKDESKEFVTIIDFIGNYKTN 581 
WP_083470389      --------------------------------------------------------------------------------     
WP_068759585      --------------------------------------------------------------------------------     
WP_120176842  596 PDRPDGEDIYALFDHNIAYELRLQGALEEEFLCPFHYFGIREFLTDAGEAGELADFARLACDERVDYILREASFHGWSGS 675 
WP_079535444  528 NAERNQAILDLEKGNLQYIFSVDIFNEGIDIPSLNQIIMLRKTESAIIFVQQLGRGLRKADDKEYTLVLDFIGNYQQNYL 607 
ADB39422      622 FIAPNLPVSDMINDGREDELFDLVTTLMDLDPTIDICVPDDFEPGFYEGLIRDQQVLNALSKTWDDLGDEDPKLDTFVEY 701 
NP_208290         --------------------------------------------------------------------------------     
WP_014269529  578 ALYGDSSYKKDSLRKVMGSGSLPLSGVSTVSFDRIAKERIYHAINGASFSSLKFLKEEYCKVRAKLGVVPSLVDFVRLDS 657 
WP_014773439      --------------------------------------------------------------------------------     
WP_014824824  570 GDKSMNKDNVRRNTVNTDYIQGVSTINFEEIAKKQIFEAINNANLSTLKMLKDSYSELKNRIGRIPMLKDFIEQNSLDPE 649 
WP_016356593  582 YLIPIALSGDNSFNKDNIRRDMLDMNYIKGISTINFETVAKKRIFDSISDSNLTNLKKLKDSYEALKNRIGRVPYLIDYI 661 
WP_083470389      --------------------------------------------------------------------------------     
WP_068759585      --------------------------------------------------------------------------------     
WP_120176842  676 RVKGLVFCRTNEEARALSDAFNRRGLRTLALSGADSQSAREAAIERLTADEPLVTGTVTEAVWERSEREPLDYIFTVDIF 755 
WP_079535444  608 IPVALSGDRTYNKDNLRKVVKEGSSSIPGSSTVTFDEIAERRIFRAIEVSSFSNAQLIRREYEDLKRQLGRIPTLLDFDE 687 
ADB39422      702 IQKTLFGPENREKKLVVFSESKETTEYVARRLREAIDRLGLAHRILTVDSHTRKDRMPLIRANFDANLPAEQQVAGESPE 781 
NP_208290         --------------------------------------------------------------------------------     
WP_014269529  658 ISPLLFIENCKNYAVFKMKVESDWKPQLSTLHVQSLTFFSKVICPGLRPYESIVISLFLKGNSEITLALITQEVEKNYGF 737 
WP_014773439      --------------------------------------------------------------------------------     
WP_014824824  650 VIISYTPTYYEFLLKMKENISSITDYEKSVLALIGKDFLSGKRIHEILLLQLLLEEESISEKSYLAALQAHNAYIHKGTI 729 
WP_016356593  662 KNFSVDPLVLINSSHTNYHLFLSKLKENPSTLTEYENQVLTMLSIEILNGKRVHELILLNKLEQNKKISMLEYKELLDNK 741 
WP_083470389      --------------------------------------------------------------------------------     
WP_068759585      --------------------------------------------------------------------------------     
WP_120176842  756 NEGVDIPDVNQVLLLRPTQSPIIFIQQLGRGLRKAPGKEYVVVVDFIGNYENNYLIPIALSGDRSYSKEVMRRYVATGSR 835 
WP_079535444  688 QGAIDPLLIISKYKSYTDFLQRYDADCRSKCNEVQLSFLRFVSKRFAPGNRELELKIINNLAIRNLAFSDFSNSFEGTKD 767 
ADB39422      782 HYDIIISTEVLAEGVNLHRANVIVNYDTPWNATRLMQRIGRVNRIGTKAKAVYIYNFFPTAQVDNDIDLQKKA 854 
NP_208290         -------------------------------------------------------------------------     
WP_014269529  738 KPNTAKLLSALSVLGNGFFQEATRNGFGQIAYCSVSGECVRPTETFLNLLHDNDYKKELEDILLLGDYEYLHS 810 
WP_014773439      -------------------------------------------------------------------------     
WP_014824824  730 EGIENVFSLNFFVEADNKKFGNKPLIIKSNSYYMFNEELQLSLRDINFKQYFVDLLECAFIKNKQFNNYEPFK 802 
WP_016356593  742 EYISDEATIQSAVNILNLSFFKDGTKSKYGSQPLIRLTDGNTLVFTDQVEKSLENNNYFRNLFKDILSVGFKK 814 
WP_083470389      -------------------------------------------------------------------------     
WP_068759585      -------------------------------------------------------------------------     
WP_120176842  836 LIPGASSIHFDPVSRERIYAAIDNAKTQTMKLLKESYLEIRRKLGRIPKLVDYEAHGSIDPTKFFEARGSYHG 908 
WP_079535444  768 ELDSAVNALSGHYFRNSPQIMGNDKLLSAEFRESFDDVYFCQYLKDIIAFGLARNKRQYSKRYKDTDFVLYEK 840 
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