Conserved Protein Domain Family
MATE_MepA_like

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cd13143: MATE_MepA_like 
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA
The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Statistics
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PSSM-Id: 240548
Aligned: 79 rows
Threshold Bit Score: 286.714
Created: 23-May-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6GCD7    13 PVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFlEDSHMISAISLTLPVFAILMGLGNLFGVGAGTYISRLLGAKDySKS 92  Staphylococcus aure...
EBA17667  13 PLGTIYLKTALPIIFVMGMNGLLSVADALFLGIyVGPDALAAVTLMFPIYMLIVALSTLVANGMSSLLARSLGAGDmESA 92  Roseobacter sp. SK2...
ABC21482  17 PIGRLFVSNALPMAVVMSMGGVLNVVDGIFVGHfIGSDALAAVSLAFPVAMVLSALTTLTGGGMSSLMARYLGAGDrGAA 96  Rhodospirillum rubr...
EAV43424  20 PILPTLARTALPIILVMSMNGLLTVVDAIFLGLiTGPDALSAVTLMFPAYMLLAALATLVASGMSSVLARKLGAGLgADA 99  Labrenzia aggregata...
EEX11815  18 PVRRLFLSNALPMAVVMSTSGLLNVVDGMFVGHfIGAHALAAVSLAFPVAMLLTALTTLTGGGMSSLMARHLGKGArRDA 97  Citricella sp. SE45
EGE59805  14 WLPGVFVRTAAPIVAITTLNGLFTVVDAYFLGAyVGPEALSAVSLIFPGLMLLIALQSLVSNGMASILARRLGAGDrQGA 93  Rhizobium etli CNPA...
ABF64887  13 RLGPVYAKTALPIIFVMGMNGFLTVADALFLGHfVGPEALAAVTLMFPGYMLVVALATLVASGMSSRLARHLGAGDtEAA 92  Silicibacter sp. TM...
EGP55812  19 SISSVFIRTSLPIILVTMVNGMLIVADAMLLGAfVGPEALGAVTLVFPFSMLLVAASAIVGSGMASVLGRRLGARDmSEA 98  Agrobacterium tumef...
EAP88858  14 GLPSLYVKTALPIIILMVMSGLLNVTDAWFLGVfSGEQALAAVTVSFPIFMLLSALGMLVASGMSSLLARALGQGDrSGA 93  Oceanicaulis alexan...
ADG20650   5 RLLPLILRLALPSVIGVTVSAAYQLLNAYFVGR-LGTAALAAMALSFPFAMCITAIGQIFGAGAASLIARSLGRADdHSA 83  Burkholderia sp. CC...
Q6GCD7    93 KFVSSFSIYGGIALGLIVILVtLPFSDQIAa-iLGARGETLALTSNYLKVMFLSAPFVILFFILEqfaRAIGAPMISMIG 171 Staphylococcus aure...
EBA17667  93 RAVFAGAHGLALGLSAVLILLfLQLGQPIAllaAGGSEHLAQMGVVYLRITVFFSPLLFVLSVNSdalRNEGRVGFMAAM 172 Roseobacter sp. SK2...
ABC21482  97 GRIFAETHGLVLAISVGLVVLwAVVGAALVdsmAAGNPKVAGLAQDYLQIMILGAPAQLMLGVHAdalRNEGRAGLIAAL 176 Rhodospirillum rubr...
EAV43424 100 EAVFAGAHGLALAMAAIVITLfGVFGDRLTlaaADGSAEIAGMSHTYLAITVAFSPLMFVLTVNAdalRNEGLAVVMAGF 179 Labrenzia aggregata...
EEX11815  98 GAVFAGAHGLALALSAALMLGaLMFGPSLVsflAAGNEPVAAPARAYLQILILGAPVQFGLGLHAdalRNEGRSGHIALL 177 Citricella sp. SE45
EGE59805  94 GRVFAGAHTLALAVTLILNIVyWSLGRQIVa-aGAGAAAVADGALLFMGTMIACAPVSFFLSLHLdglRCEGKIGFMTLA 172 Rhizobium etli CNPA...
ABF64887  93 QADFAAAHGLALSVAVGLMAAfALWGSAVAhaaAGGDRLLADMGHTYLRITVGCTPLLFVLSVNSdalRNEGRAGLMALM 172 Silicibacter sp. TM...
EGP55812  99 CEVLASAQGLAVVLGVVTIALfFLGGGVIVtwmAAGNQHLADTGWRFLAVSFVAAPVMFLLTVHSdalRTEGRVAFMAMA 178 Agrobacterium tumef...
EAP88858  94 ESVFASAHALSLAISLVLVLLyVLLGGPVLtrlSLGDEALAAEAARYIGVLIWGAPIALILSVQAdglRNEGQAGFMALA 173 Oceanicaulis alexan...
ADG20650  84 NDYASHALWSAMIIAGITAIAgWQLAPTLLt-wLGAGPSILPLAVAYLHWLLAGYVAVVFNMVCGfivRADGNTVLSMTT 162 Burkholderia sp. CC...
Q6GCD7   172 MLASVGLNIILDPILIFgFDLNVVGAALGTAISNVAAALFFIVYFMKNSDVVSVniklakpnkEMLSEIFKIGIPAFLMs 251 Staphylococcus aure...
EBA17667 173 SLLVSLANIGFNYMLIAiLDMGVAGSAYGTAAAQMLAFAIIFAFRLFGDTSLRPatllshsmrGSWGRILALGAPQSLNf 252 Roseobacter sp. SK2...
ABC21482 177 SVLVNLFNIGANGLGIVvLGLGISGSALGTVAAQALGLALVIGVRGHSKGLLPLsvlrarnwlGAWSQIIRLGLPLCLSf 256 Rhodospirillum rubr...
EAV43424 180 SLLVSLANIVFDYLLIAvFDYGVAGSAAGTVLAQALALAIMLGLRLSGKTELSPsallrhpltSSWRTILTLGTPQSLSf 259 Labrenzia aggregata...
EEX11815 178 SVIVNLLNVAANYIAIVvLDFGIAGSAIGTVAAQALGVMLLLLVRKRDPALLPLdmirnaswlTGWRQILALGLPLSLSf 257 Citricella sp. SE45
EGE59805 173 TLSASLLNIFANWLFMAvMHWGVFGSAAGSIASQFACLAAVLAYRWRRPAALRPyrg---lalGEWPGVVVFGAPMSLGf 249 Rhizobium etli CNPA...
ABF64887 173 SLVVSLSNIAFNYLLIAqAGLGVAGSALGTALAQVLALSLIVAFRLRGDTVLRPsclwrqslwGGWGRMLALGAPQSLNf 252 Silicibacter sp. TM...
EGP55812 179 GVILTLANIALNALLIGyFQFGAAGSAGGTALAQLIALLLIIGYRMAGKGILPVvgf---rigRSWGEMLALGIPRSMNf 255 Agrobacterium tumef...
EAP88858 174 GLGVTLANIAFNAVLIIaLQMGAAGAAIGTVLAQGVSVVIILAWRVRHPLLMSAsfsgwfrtrKGWAHILALGAPPALGl 253 Oceanicaulis alexan...
ADG20650 163 QVSSFAMNAALDPVMIFwFGLGIEGAGIATFLAQLCGLTLYWRHFAGRHGAIVLswpsvgrcgCRLASIARIGIPPALNt 242 Burkholderia sp. CC...
Q6GCD7   252 --ILMg-FTGLVLNLFLAHY--GNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMANK-GRMKDVIKAVIMSIGV 325 Staphylococcus aure...
EBA17667 253 igLALg-SAAIITALQWVGGpgYADTITAYGIITRVITFTFLPLLGLSFAMQTITGNNFGAALwHRSDRSLRLALWVAFI 331 Roseobacter sp. SK2...
ABC21482 257 igIAMv-ASVVIVSLRLSAGtdYNALVAAYGVVTRLLGFAFLPQMAIALATQSITGNNAGAGRtDRARAALRLALGAAFL 335 Rhodospirillum rubr...
EAV43424 260 igIALg-SAATITALQSAGAsgYEATVAAFGIVTRIMTFCYLPLLGLAQALQAMIGNNSGAGLwHRSDNTLRLGLVVAFV 338 Labrenzia aggregata...
EEX11815 258 --IGMalVAGTVLLAIGNTAadHGTYVAAYGIVTRILGLAFLPQMAIALTTQSITGNNVGAGRtDRASAALRLAIGCAFL 335 Citricella sp. SE45
EGE59805 250 igISLa-SAAILVNISLWGTddHVATVAAYGIITRIMTFTYLPLLGLSIALQTIAGNNHGAGLrLRVGRSLQIAMGTAFV 328 Rhizobium etli CNPA...
ABF64887 253 igIALg-SAVIMFALQWVDVsdYATTVSAYGVITRLLTFTFLPLLGLSHAMQSITGNLYGAGQiLRVGQSLRFAVVSALI 331 Silicibacter sp. TM...
EGP55812 256 igLSLs-SAAVLFSLHRLNLgnQETMVTAYGVVMRVMTFAFLPLMGMNLALQAIVGNTIGAGQaDRASDTLRLAICVSAV 334 Agrobacterium tumef...
EAP88858 254 fgVALg-SLTVLSVLQLSKAedYQGIVAAYGVATRVMTFAILPVIGLSQALQTVTGINHGAGLtGRVRDSLRFALLTALC 332 Oceanicaulis alexan...
ADG20650 243 -lLAI--AAMSMLNAFAARY--GEASVAAIGLASRLAMLAALPLYGLCSGAQSVVGFNVGAGNwTRVAQAVRAMVAVALT 317 Burkholderia sp. CC...
Q6GCD7   326 IFVVCMIAVFTIGHHMVGLFTtDQDIVeMATFILKVTMTSLLLNGIGFLFTGMLQATGQGr--GATIMAILQGAIIIPVL 403 Staphylococcus aure...
EBA17667 332 YCVVVQIVVMQMPSQIAGAFVkDVAVIdEVSRILPVMASVFFLVGPLMMIATYFQAIGSAs-kAALLGLTKTYAFAIPLT 410 Roseobacter sp. SK2...
ABC21482 336 WCLPVVLAGVFAGTTLGSWFSdDPAVIdAVAEILRPMMLFYAASGPVLVLALYVHALGQPg-rTAALTLVKPWLLTPLLI 414 Rhodospirillum rubr...
EAV43424 339 YCALAELGLTFFSHEIGFAFVdDPRVAaDVSRILPVMVALYFVAGPLFMVATYFQALGDAg-rAALLSLAKPYAFFLPLV 417 Labrenzia aggregata...
EEX11815 336 WCLGVTLTAMLAGEMLGALFSdNQEVIiAVAAIMRPMTALYAVTGPILVLAMHYQAMGYPl-rTAVLTLGKPWLLTPVLV 414 Citricella sp. SE45
EGE59805 329 YCSLVEIAVEVLAGRLGAVFVvDPTIVaEVRRILPWTIGAYFLFGQMLVLSSYDRRRAARgdlRPVAALSAHPAADLPAA 408 Rhizobium etli CNPA...
ABF64887 332 YCAVMQAGLTWGAAWIAAWFVdDQGVIeDVARILPILGALFVLAGPLMMVAMHFQAIGDAp-rAALLGLSKPYLFSIPLT 410 Silicibacter sp. TM...
EGP55812 335 YGLLTQLTLSLARDGLGWLFVgDATVAlEVARIVPVYVAAYFAFGPVLMAASYVQAVGKVr-qTAILSLGRTYLFAIPLA 413 Agrobacterium tumef...
EAP88858 333 YGVVVEGSVLLFAPQIGGFFVsGEALApQIAFILRRLMALFALGAPLFLLGLYFQAQGDAv-rAAILGLAKPYLLFIPLV 411 Oceanicaulis alexan...
ADG20650 318 FAGVYAGSVVWQARTIIGWFAhESATIeIGSRAILLFHCALPVLGVQQVCLLFMQAKGNAi-wATLVAVLRHGLFLMPLM 396 Burkholderia sp. CC...
Q6GCD7   404 FIMNAlFGLTGVIWSLLIAESLCALAAMLIVY 435 Staphylococcus aureus subsp. aureus MSSA476
EBA17667 411 FLLPIwFGEIGIWIAGPLAEVMLLGLTIMVLR 442 Roseobacter sp. SK209-2-6
ABC21482 415 LALSIgFGVSEMWLAFPMADAIILMLAVMIGR 446 Rhodospirillum rubrum ATCC 11170
EAV43424 418 FVMPVyFGEGGIWLSSPLAELMLLVVTLALLT 449 Labrenzia aggregata IAM 12614
EEX11815 415 VVLNAhSGLQGLWYAFPAADAALALVALMIIF 446 Citricella sp. SE45
EGE59805 409 FRLRGaGDMDGSDLCRGRHGRSCRAGAVAKRK 440 Rhizobium etli CNPAF512
ABF64887 411 FMLAAlWGEPGIWLAAPVAEAGLLVLTGLVLL 442 Silicibacter sp. TM1040
EGP55812 414 LTLPLiWGETGIWAAAPMADLMMLVLAGLIWR 445 Agrobacterium tumefaciens F2
EAP88858 412 IGLGLgLGSDAIWWASPLADIGVLALAIIVFA 443 Oceanicaulis alexandrii HTCC2633
ADG20650 397 ALLQHaYGQDGLLFSVAAADMAAGLIAMVILY 428 Burkholderia sp. CCGE1002
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