4I6M,5TGC,3WEE,6VZ4,6VZG


Conserved Protein Domain Family
ASKHA_NBD_ScArp9-like

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cd10208: ASKHA_NBD_ScArp9-like 
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins
Saccharomyces cerevisiae Arp9, also called actin-like protein 9, chromatin structure-remodeling complex protein ARP9, or SWI/SNF complex component ARP9, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp9 forms a stable heterodimer with Arp7 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.
Statistics
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PSSM-Id: 466814
Aligned: 27 rows
Threshold Bit Score: 294.6
Created: 6-Oct-2006
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:Arp7/Arp9 heterodimer
  • Structure:3WEE; Saccharomyces cerevisiae Arp9 in complex with Arp7, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
4I6M_B      8 SILIIYPRSQTTLVQFGlne--etfTVPELEIPTQIyrttrqdgsyt--------------------------------- 52  Saccharomyces cere...
3WEE_A     17 SILIIYPRSQTTLVQFGlne--etfTVPELEIPTQIyrttrqdgsyt--------------------------------- 61  Saccharomyces cere...
GAA94194    9 LYLILDISPSHISAGLGlgd---vlQRPRHTIKLLAglptdlpswtwqdllvgqald----------------------- 62  Mixia osmundae IAM...
CEG64841    9 NFVVINVGSNITTAGIG--------MHDTNKAPAVFvn------------------------------------------ 38  Rhizopus microsporus
CDZ97182    7 KVIVLDSSSDFVRVIYGlde---llKPPSSEVLARVgkrlqpdpatsqdeydqaststtpap------------------ 65  
KNE59348    8 RYVFLAPGSAGTLAGPTsa-----lEPKCKKYPSDRn------------------------------------------- 39  Allomyces macrogyn...
KNF06320    8 NLLIVSLSTHAHSVQVGlgvspeviLTPSITLPTIAylkpelaqsslprkw----------------------------- 58  Puccinia striiform...
KWU42384    7 LLLIFDLTSTLLRAGVGvhd---liRGPLIELPTRVgrmatksghrvedflvgaql------------------------ 59  Rhodotorula sp. JG-1b
OAJ39568   11 NLLVIDPGSLYTRAGLAdy-----qNPPALTAISRIsdkelaaeleaqeiaqrealletqtaskelllteqtaqdtdatd 85  Batrachochytrium d...
ORX73535    9 SFVVIELGSHTTRALMNtsd---vnFSERKVIRTRCgqlkpveenehegseagskmqataavddgepving--------- 76  Linderina pennispora
Feature 1                                                                #                    
4I6M_B     53 ----------------------------------------yhstnkdnkaELIKPIQNGEii--------dISAFTQFLR 84  Saccharomyces cere...
3WEE_A     62 ----------------------------------------yhstnkdnkaELIKPIQNGEii--------dISAFTQFLR 93  Saccharomyces cere...
GAA94194   63 -----------------------------damssdstltlirpfehilepDSAPRQTAGMtae-----qasLTALEAILQ 108 Mixia osmundae IAM...
CEG64841   39 ------------------------------------------------maDFNYPIKDNRis--------nWKDLEDCLH 62  Rhizopus microsporus
CDZ97182   66 -------------------------gskppavvyligsdlekaeaageelEIIWPFRDGWt---------dWKSIEALWK 111 
KNE59348   40 -------------------------------------------------eEGPAPIDRGLvq--------dWDALGQHWS 62  Allomyces macrogyn...
KNF06320   59 -----------------------------------sdysfdpqpdllpiqLFSTQSQNGSqisqssplvtdWKAIDALFR 103 Puccinia striiform...
KWU42384   60 -------------------------------aaaeavtaaggvqdfdiidPITIDVKTGAfhv------tdWNALEAVFR 102 Rhodotorula sp. JG-1b
OAJ39568   86 mmvdspshavvantatttvspaavadelrvntrhdanesgkgsasdhassAWVQPIQNGQva--------dWDALQVLWR 157 Batrachochytrium d...
ORX73535   77 ---------------epaekddgsgdvikdtednsyvfgsaleaadpstiERAVDFIDGEvv--------dWDMLSAFLR 133 Linderina pennispora
Feature 1                                      # ###  #                                       
4I6M_B     85 LIFVSILSDranknqdafeaeLSNIPLLLITHHSwSQSDLEIITQYVFESLEINNLIQLpASLAATYSXislQNCCIIDV 164 Saccharomyces cere...
3WEE_A     94 LIFVSILSDranknqdafeaeLSNIPLLLITHHSwSQSDLEIITQYVFESLEINNLIQLpASLAATYSMislQNXCIIDV 173 Saccharomyces cere...
GAA94194  109 HLMFGLLSMpa---------rPLGYHLIVLPPAGlPYSYSEGITRLVFERLYLPALAIYeRPLAQLYALg-yTSGLAVDI 178 Mixia osmundae IAM...
CEG64841   63 TILFKEIGIkk---------sRNECPVLLSVPVQwTKLEHERITQIFFENFNVPGIYIApQPLLTLFGCg-aVSGIVVDI 132 Rhizopus microsporus
CDZ97182  112 YALYQSGPYhr---------rTNESPIIVTHPSLfSNNQIHLLTQVLFERLNVPAISLLpRPVGALFAGn-aTTGVVVDI 181 
KNE59348   63 SVLTDRLGIsk---------aQGDHPIFLLVPMAwKKSDVERAAKFLFETYRIPGLAIApEPVAALLGAn-aVTGLVVDI 132 Allomyces macrogyn...
KNF06320  104 HLLFNRLKLsk---------pPVAQHILLSIPPNlPNSIRDKFTQLFFENLQAPALFLAeSPLLQTLACn-cTSGITIDI 173 Puccinia striiform...
KWU42384  103 YAMHTSLQLqr---------pPLAHPTVLSIPPNlSPSTVDQLHRLLFERLLVPQVLVStRPFFAAGAAg-iLSGIVVDI 172 Rhodotorula sp. JG-1b
OAJ39568  158 KILVNHCGVer---------aTNINPVLLTVPVSwSRSDQERATRILFEYINVPGMFLLdQPVAALYGAg-vTSGLVVDI 227 Batrachochytrium d...
ORX73535  134 YVVTKEFSIki---------sDNGSPVLFSVPPLwPKTDLENLAQIAFEHLNAPAILVTeQPLMAVYGNg-aMTGLVIDI 203 Linderina pennispora
Feature 1                     # ##    # #                                                     
4I6M_B    165 GTh--HTDIIPIVDYAQLDH----LVSSIPXGGQSINDSLKKLLpq---------------------------------- 204 Saccharomyces cere...
3WEE_A    174 GTh--HTDIIPIVDYAQLDH----LVSSIPMGGQSINDSLKKLLpq---------------------------------- 213 Saccharomyces cere...
GAA94194  179 DAt--GTEINVVLDNQVQPQ----ARVRCPIGSDDCDRYLADLLlradpqlpallap----------------------- 229 Mixia osmundae IAM...
CEG64841  133 GSq--ITDINIVVDSNVQLQ----SNFMIPIGGNHFDAYFLELLkkdthlveq--------------------------- 179 Rhizopus microsporus
CDZ97182  182 GLe--ETSITPVVDSTVCPN----GCLETSLGVRHCELWMASLLtkeeqliktlqspspssleepesspkeqpaspsdtt 255 
KNE59348  133 GFt--TTTVTPIVETNAIRH----ATQIVPVGTSDIIARLQALCaskqpglsvdaalaalkskllda------------- 193 Allomyces macrogyn...
KNF06320  174 GAr--STLIGFVSDSIVLNQ----SCHFYPIGEQDCDDYLISLLlnenpelpsqlgw----------------------- 224 Puccinia striiform...
KWU42384  173 GYrgeGTEISAVHENQVVPAasgfRLADLDEGVCDDYCLYKILEadptieqqlldaktaassssssssgqpvtfapgela 252 Rhodotorula sp. JG-1b
OAJ39568  228 GHt--TTDISPVFENVAVYS----ASVTIAVGGQNIETYLVQLMsgdekfv----------------------------- 272 Batrachochytrium d...
ORX73535  204 GHa--TTTVTPIIDSCVLTS----SVQISSIGGQAVTQNLLQQLqsda-------------------------------- 245 Linderina pennispora
Feature 1                                                                                     
4I6M_B    205 -----------------------------------------------wDDDQIESLKKSPIFEVLSDDAKKLSsfdfgne 237 Saccharomyces cere...
3WEE_A    214 -----------------------------------------------wDDDQIESLKKSPIFEVLSDDAKKLSsfdfgne 246 Saccharomyces cere...
GAA94194  230 ------------------------------------dgevspggiqaaLLAIVSSLKDQDAIKFASELLDLNHvapgmse 273 Mixia osmundae IAM...
CEG64841  180 ----------------------------------------fnqhqlelDLDFAKYVRELPGICNVAFGHDLEDdkftaql 219 Rhizopus microsporus
CDZ97182  256 ap---------sttapgeseaskeinaapttpptpplppvsdedlhdtLIRLSEHMWKNNLIRPVLAGGEPYSaeqeeeg 326 
KNE59348  194 -------------------------tppsspltapstaaarkkaappaTSSLLAELTASPNSAGASSSADDQTsqpsspa 248 Allomyces macrogyn...
KNF06320  225 ------------------------------------tstnqaetlyhaLLGFVSNLKADGHIRFEPQLNTLALtgtdlrs 268 Puccinia striiform...
KWU42384  253 namrrvvsdlkvqnaisfespllgstitrllqlgiqqaagegeegeegTLDVAKAIVEGKVDEIVRGGGGDAHkdddeeg 332 Rhodotorula sp. JG-1b
OAJ39568  273 -----------------------------------------asygkyiGKDLARAFIQSPAFFAPSLSGIEQPnaef--- 308 Batrachochytrium d...
ORX73535  246 ---------------------------------------------gvvRQNLLVRVKESGLCKLGAPGNALETvefk--- 277 Linderina pennispora
Feature 1                                                                                     
4I6M_B    238 nededegt------------------------------------------------------------------------ 245 Saccharomyces cere...
3WEE_A    247 nededegtlnvaeiitsgrdtr------------------------------------------------evleerergq 278 Saccharomyces cere...
GAA94194  274 avqsaavtegteegefdiarlvaqg-------------------------------------------kvdalvrgktsg 310 Mixia osmundae IAM...
CEG64841  220 snameemptaateelldd---------------------------------------------------------dnpks 242 Rhizopus microsporus
CDZ97182  327 vtdiaaalvagrekaliearaakshksa------------------------------------akkeeeakkraaqaaa 370 
KNE59348  249 d------------------------------------------------------------------------------- 249 Allomyces macrogyn...
KNF06320  269 qeeeengitdvaqaivsgkadkiigrqtsnnssqggrrptltgkllaaeiqketdtiivsnssnsqqpvnlsvppsplld 348 Puccinia striiform...
KWU42384  333 gkfvrvsnpyl--------------------------------------------------------------------- 343 Rhodotorula sp. JG-1b
OAJ39568      --------------------------------------------------------------------------------     Batrachochytrium d...
ORX73535      --------------------------------------------------------------------------------     Linderina pennispora
Feature 1                                               #  ## ##                              
4I6M_B    246 ----lknsdlefntfwdekGNEIKVGKQRFqgcNNLIKNISNRVGLTLDNi----------------------------- 292 Saccharomyces cere...
3WEE_A    279 kvknvknsdlefntfwdekGNEIKVGKQRFqgxNNLIKNISNRVGLTLDNi----------------------------- 329 Saccharomyces cere...
GAA94194  311 eatpstedvvsvphplrpdGPEISIGPIRHryaEPLFDPSLIINDGPSAStgqslslqe--------------------- 369 Mixia osmundae IAM...
CEG64841  243 kgdedgvgdipetvdieykGHTFTIGPYRHqviDPLFSPELIQVQCLSLPeamrl------------------------- 297 Rhizopus microsporus
CDZ97182  371 aaqatgdqrdadvtmvefeGRELWIGHVRQrfcEPLFEPSLLQGIKGLEGlnggrpdelvg------------------- 431 
KNE59348  250 -----------sgpnhasiAAKIDPILLRQavdDVLFTGAPKSLVDAIAAav---------------------------- 290 Allomyces macrogyn...
KNF06320  349 cqpsqavpvsteslslpreQAGIRVSKTRHrhaEPLFAPTLLRSIGPIFSrfgleryavrytqdlia------------- 415 Puccinia striiform...
KWU42384  344 --pgttatgtdpsssatntNTTLRIGPIRHrylEPLFFPSVLACLAPTTPsssssssssspsggetlasrlfgteyakfa 421 Rhodotorula sp. JG-1b
OAJ39568  309 ----------------dfkGQKIDIGSWGFraiDVLFKPELIGKDVPGIHdamhl------------------------- 347 Batrachochytrium d...
ORX73535  278 ----------------dgdKTYTLPTRILHsapQVLLTPSSEGSTPLTTMirqa-------------------------- 315 Linderina pennispora
Feature 1                           ##                                    #####               
4I6M_B    293 ----------------------DDINKAKAVWENIIIVGGTt---SISGFKEALLGQLLKDHLIIepeeekskreeeaks 347 Saccharomyces cere...
3WEE_A    330 ----------------------DDINKAKAVWENIIIVGGTt---SISGFKEALLGQLLKDHLIIepeeekskreeeaks 384 Saccharomyces cere...
GAA94194  370 --------------aaalsvssLEAPMRPSAWDIVCVTGPPs---RIPGVASAVIKAASQYLIDPe-------------- 418 Mixia osmundae IAM...
CEG64841  298 -----------------avmncEPPEIRPKLWESIAITGGCc---LTTGLSKRLKVEVQMVLPQSe-------------- 343 Rhizopus microsporus
CDZ97182  432 -----------vqelvqmgiacVNGPEKVLCWEGVSVVGEMa---RVKTFPVTLLSHLMQYILTDp-------------- 483 
KNE59348  291 --------------------aaVEPAARASVLDAVLLTGGGg--aLIANLEERVQLEYAQQYLPVs-------------- 334 Allomyces macrogyn...
KNF06320  416 ------eddtlvesiqrginklISPDQQKDVVGQFVLTDGSglmcRTEGLGIAISSELQTRNSGS--------------- 474 Puccinia striiform...
KWU42384  422 gpgatlshaglheavgvvlasvPDEGVRNAVSEAVVIVSSGri-aNNRALGPALIPLLSPFRSDP--------------- 485 Rhodotorula sp. JG-1b
OAJ39568  348 -----------------vvsnsCEPEKRLFLWENILLVGGCs---LIRGIKDRIESELAVLLAASe-------------- 393 Batrachochytrium d...
ORX73535  316 -------------------vlgSEIDKRPLLWDSIHLVGGSs---RFPGLQEHLERELEATVLPAs-------------- 359 Linderina pennispora
Feature 1                           ######                                                    
4I6M_B    348 vlpaatkkkskfxtnstafvptIEYVQCPtv------iKLAKYPDYFPEWKks-gySEIIFLGAQIVSKQIFThpk-dtF 419 Saccharomyces cere...
3WEE_A    385 vlpaatkkkskfmtnstafvptIEYVQXPtv------iKLAKYPDYFPEWKks-gySEIIFLGAQIVSKQIFThpk-dtF 456 Saccharomyces cere...
GAA94194  419 ----------------------SGSDTQArv------aRLGKIPDYFSEMKdh--pDLAAYLGGAILAKITFSan--vgA 466 Mixia osmundae IAM...
CEG64841  344 ----------------------NAGDTQPri------iNFLRIPEYFTVLKekenqVYSTWLGAEIVAKLVFIda---kN 392 Rhizopus microsporus
CDZ97182  484 ---------------------eSISEVQPkn------tRFLRIPKYFPEYVee-ggWSAPFLGASIVGKLVYAdlt-gkY 534 
KNE59348  335 ---------------------tRAGEYQPre------vTFRGLPEYLEAYQdh--aEWAAYLGGSLLAKLMFPda---kS 382 Allomyces macrogyn...
KNF06320  475 ----------------------NSLPQPGlqgd--gifKPLKVPEYFSEFKgk--pEYLGFLGGCIVAKLVFNdassnkL 528 Puccinia striiform...
KWU42384  486 ----------------------SAGVYDPegtapsrttRFAKTPHYFSSFKdr-sgDWAVYLGACIMGKLLIGdas-skL 541 Rhodotorula sp. JG-1b
OAJ39568  394 ----------------------TSSEYQAkd------vKWIKLPDYFVEFKdr--sCDAAFLGGSITAKLVFTss--gaM 441 Batrachochytrium d...
ORX73535  360 ---------------------nIFANSQTre------iKFVPIPDYFNGWRnm--gYRASLLGASITAKIALNds---kH 407 Linderina pennispora
Feature 1                    #  
4I6M_B    420 YITREKYNXKGPAALWDV 437 Saccharomyces cerevisiae S288C
3WEE_A    457 YITREKYNMKGPAALWDV 474 Saccharomyces cerevisiae S288C
GAA94194  467 YLSKQDYNLKGPAIVKLL 484 Mixia osmundae IAM 14324
CEG64841  393 YVSKVDYNEFGPSVIHTK 410 Rhizopus microsporus
CDZ97182  535 FTTKVDYNRHGPARMTSA 552 
KNE59348  383 FVLRDEFDAGGASVVHTK 400 Allomyces macrogynus ATCC 38327
KNF06320  529 WMSKPDYNKDGPYISRKL 546 Puccinia striiformis f. sp. tritici PST-78
KWU42384  542 FMSKQDYAAHGPAHYRLL 559 Rhodotorula sp. JG-1b
OAJ39568  442 YLTRADYDEFGPAASFLK 459 Batrachochytrium dendrobatidis JEL423
ORX73535  408 NITRTEYNENGPSIVHTK 425 Linderina pennispora

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