Conserved Protein Domain Family
DUF621

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pfam04789: DUF621 
Protein of unknown function (DUF621)
Family of uncharacterized proteins. Some are annotated as having possible G-protein-coupled receptor-like activity.
Statistics
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PSSM-Id: 398453
Aligned: 15 rows
Threshold Bit Score: 340.456
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003112400   32 ETVPDVQKTWIYYIVISCFVLTAIASTLLTGGFLVMSVVLWNHLKT--------MKFFWFLTQLTFSSFMISILNLIFNV 103 
NP_001122959   37 AEIPPEDKNFLYYFIIATFTASTIISTLLTGAFLVASVILWKRFKH--------MKFFWFLCMLTLSIFIISILNLLINV 108 
4_pfamImport    1 GNIPPEDKDGLYYFIITLFVMSTFASTILTGVFLALSVILWSHFKK--------MIFFWFLTQLTISVFIMSSLNFLINV 72  
XP_003112553   63 AEIPPEDKEGVYYFIVTLFVFATFASTLMTGAFLAMSIALWGHFKQawkkfhlnMKFFWFLTQLTIAVFIMSSLNFLINV 142 
XP_003112735   28 AEVPPNDKGSIYYLVISLFVMSVFASTLLTGAFLGILILLWGHFKT--------FKYFWFLSQLTIFVFILSALNLIINV 99  
XP_045094052   32 AEVPPQQKTSLYYLVITLFVISVIACTLLTGAFLVLLILLWGQFKS--------IKYYWFLSQLTVSVFFLSSLNLVINV 103 
Q6BES6         30 dTLPESEKNWMFYFVILLFVLSTVTATLLTASFLIMAVFLWNHLKP--------MKFFWFLLQLTISAFILSTLNLVFNV 101  Caenorhabditi...
EGT32880      309 GEIPEDQKQGTYYFVVSFFVFSTIVSSLLTSVFLVLAITVWNHFKR--------IRFFWFLIHLLISVFIISASNLLMHV 380 
2_pfamImport    1 -------QKWTLLSIVGLFVTTTVVSTLLTAAFLVLSILLWSHFKH--------IRFFWFLVQLILSVFIISGSNLLIHV 65  
6_pfamImport    1 GEIPESAKTGLFHFVVGLFVVSTVVTTLLTTVFVALIVILWGYFKP--------MKFFWFLTQLTISVFIISSSNLVINV 72  
XP_003112400  104 PATLLSVATKQLVPSELYFIVLYLMDFFLHSILFSNLVIAFQRLFVFFPSKKMEF--LFGTPLLYLWMILIYTLPIFILF 181 
NP_001122959  109 PATLFSLLTKDFVKSEAFLLISYIIDICHYTILFCNLVIAVQRCFVFFFRNLADS--VFDTPFMYAWMISVYLLSLLVVY 186 
4_pfamImport   73 PATLFALITKEFVQSASFYYMSNVIDFCHNAILFSNLIIAIHRMFVFFFKKHTDI--AFEKPITYFWMGMVWVLSAFVVV 150 
XP_003112553  143 PATLFSLITKEFVKSDAFFLMSNVIDFCHNAVLFSNLLIAIHR------------------PLVYIWMILVWILSGAVVL 204 
XP_003112735  100 PATLFSLITIDFVSSDIFTILSYTIDYLHYTILISNLVIALQRFSVFFFRQLTYR--VFDSYVIYIWLLMIWILPCSIMF 177 
XP_045094052  104 PATLFSLLTPDFVTSDIYIILSYTADYMHYSILISNLVIAIQRFSVFLFRNYSST--LFDSHFVYIWLVIVWLAPGAIIF 181 
Q6BES6        102 PATLFSVATEQFVQTNLYLIMSYVIDFCLHSILFSNFVMAIQRFAVFFHLHISDI--IFESPYIYIWLVMIYVLPSLTLI 179  Caenorhabditi...
EGT32880      381 PASL-GLIEEHHFETEIFHFISYLIDFCHYSILFSNVVIAINRAVIFFQNSSSYSniVFEPPFIYIWLSVVWLLSFGVES 459 
2_pfamImport   66 PATL-GLLSPSTLNSEIFIFVTYLIDFSHYSIIFSNTVIAINRGVLFFKKSSVAAk-TFESPFIFFWFLLIWLMPLGIDY 143 
6_pfamImport   73 PATL-SLVSKEAAQSGLFSFISYLIDFCHYSIIFSNLVIAVQRAFVFFFRHSTDT--AFSSPVIFIWLVSVWVLALIVEI 149 
XP_003112400  182 SLFQNDCSYKY----NAIEQKFKLYCPKVVsgieSLTKEPPEGIQILENVIQVGIPVVILVLYIALVIRVIKLKRSKRNT 257 
NP_001122959  187 AMMYNNCRYRY----SLNVLHYELYCQTSA----VVNLPPPKAISIMEIVIQFAIPCIIFGIYIALTIKIMIMKQSSLKS 258 
4_pfamImport  151 SMIMNNCQYEYd--eRILMKHYVLSCETSSg---IKNIAPPTIVQTIEILIQFILPIFILGIYIAIIIKIILMKKAALNK 225 
XP_003112553  205 SMMSKNCRYEYd---MAVLEHYVLKCRTESg----IAISPSSVIQMIEIAMQFVIPIFILAVYIALVAKICTIKQGAQNN 277 
XP_003112735  178 VMVRNNCRYLYmlspRKVNGHYNLYCPTQNs---LVDTAPPELVRIIELTLQFGIPVFILAMYVSIIMKIITMKKASLNR 254 
XP_045094052  182 FMAYNNCRYVFl---KAKKDNFVLKCETAGs---VVDLPQPEWIRFMELALQFGIPVLIFCMYVAVVFKICSMKKSALNK 255 
Q6BES6        180 FLGQDNCMYRF----DNREQKFTLTCFNTVgt-nKVKIEIPRIIQIIEDTIQIVIPIIILILYIALVIKIIKMKKTSRNK 254  Caenorhabditi...
EGT32880      460 VLISYDCSYKY----NHLRTRLQFICQKPAes-slIFLGNPRIIQVIDAIIQIALPVLILLIYFSIILRMILMKKVSLVN 534 
2_pfamImport  144 VLMSAGCRIQL----NLKMKNFRMKCEKYSnf-fLIHTETPLGIQIIDVLLQIGLPAFIFLIYSSIVVSIAFARNLSLKD 218 
6_pfamImport  150 ILMTSNCKYRH----DKKTPVYQLKCEVKGqtnlVVNKSLPGGIQLIENIVQIGIPILIFGIYCAIISKIAYMKQSTLSK 225 
XP_003112400  258 NEIIILKQAFFIFVMFQIYNIVTLFGKTLYINVATAFYLKRAIHTA--------------EIFAGAATPCIVFSTSREIR 323 
NP_001122959  259 SEITILKQAFFVFFVFQVSSVVFLLCQTVKFGVATAFLIKRVINTM--------------EILAGAATPCFFFFTSKEIK 324 
4_pfamImport  226 YELTILKQAVFIFCLFQISSSVFLLCQTIKFEIATAFLIKRIINTT--------------EICAGAATPCFFFFTSKEIR 291 
XP_003112553  278 YELTILKQAVFIFALFQISSIVFLLCQTLKFKVATAFLIKRVINTVnqcmsnyksfeiqtEIFAGAATPCFFFFTSKDIR 357 
XP_003112735  255 HETRVLIQAIIIFVLFQASSVVFLYCQTFDFTVPTAFLIKRIINTL--------------EIMAGAATPCFSFFTSKEIR 320 
XP_045094052  256 QETRVLVQAIIIFLLFQASSTVFLFCQTLSFNAATAFIIKKSINTL--------------EIFAGAATPCFSFFASEKIR 321 
Q6BES6        255 TEIIILKQAFFIFLMFQIYNIIVLYGKTLKMTTVTAFYLKRAIHTA--------------EIFAGATTPCFVFFTSKEIK 320  Caenorhabditi...
EGT32880      535 TEKTLLKHSIFAFVIFQSPNCILLISQSFKMSNVSAFLIKRFVNTM--------------EIFGGAITPTFFFFTSREIR 600 
2_pfamImport  219 HEKTILKQAIFTFVVFQAPSLVFMGANFFYIEELEAFLIKRFVNTM--------------EIFGGIATPSFFFFTSQEVR 284 
6_pfamImport  226 NETSILKQSIFVFVAFQSSSIVFLIAQNIEITNVTAFLIKRFVNTM--------------EILAGAATPTFFFFTSKEMR 291 
XP_003112400  324 KVVSSRIGSGS 334 
NP_001122959  325 KMASVKSSMNN 335 
4_pfamImport  292 KLVSVRVSLTT 302 
XP_003112553  358 KLVTVKVSASS 368 
XP_003112735  321 KMLSAKIASYS 331 
XP_045094052  322 KMLSSKVPAIS 332 
Q6BES6        321 KLVSNKITAGS 331  Caenorhabditis elegans
EGT32880      601 KIFASRVYATN 611 
2_pfamImport  285 KIMTSRVYATN 295 
6_pfamImport  292 KFVSTRVSAAS 302 
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