1H2T


Conserved Protein Domain Family
MIF4G

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smart00543: MIF4G 
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Middle domain of eukaryotic initiation factor 4G (eIF4G)
Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Statistics
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PSSM-Id: 214713
Aligned: 48 rows
Threshold Bit Score: 60.4519
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1H2T_C               9 EDHLESLICKVgekS---AC--SLESNLEGLAGVLeADL-------PNYKSKILRLLCTVARLLP-----EKLTIYTTLV 71   human
BAA92646           194 LKKNTAFVKKL---K----T--ITEQQRDSLSHDF-NGL--------NLSKYIAEAVASIVEAKLk---iSDVNCAVHLC 252  human
FlyBase:CG2253-PA  104 LKKNTAFVKKL---K----L--FTATQLDGLLREI-SAL--------NLSKYISEICAALVEAKLk---mTDVPAVVTLA 162  fruit fly
AAB54133            14 EKKLQGVIGKV---GentGS--SIECNLDKLTAFL-HDDle------kYRASIIDIIAGCAIYLP-----NRVTVYTTLV 76   Caenorha...
FlyBase:CG7907-PA   27 VKTVEQLMREL---SfpgHT--PLELKLGNLGYLL-GKGms-----vDLKENLINELVICLGYYP-----GQASAYATLV 90   fruit fly
AAD22677             8 LLRIGEKGPEY---Gt--SS--DYKDHIETCFGVI-RREie------rSGDQVLPFLLQCAEQLP-----HKIPLYGTLI 68   thale cress
CAB11644            41 LKKNTAFMKRC---K---SS--LTSENYDSFIKEI-KTL--------SLKKFIPEITAAIVEGMMkckatKDILSSVKIV 103  fission ...
BAA76378            42 INNICKDIRRL---Ge--AG--DIENLIADTNYIS-NPIvaefekiDNLRNSILSTIYALITEQP-----HKISAIANLI 108  Candida ...
CAB11293            34 AARIKKDITFL---Ad--PR--GNSVAADDINYVA-MSLsre-andPETISTILDCIQTTAFIIP-----VKIPHLATLI 99   fission ...
EEU05624            37 CKEMMPDIRTI---G---ESvkAFEDDIKFLSEAI-MNEyg---heDYFNNALLSTLNAVVVEQP-----QKQAAIALLT 101  Saccharo...
1H2T_C              72 GLLNARNY-NFGGEFVEAMIRQLK-----------------------ESLKANNYNEAVYLVRFLSDLVNCHVI-AAP-S 125  human
BAA92646           253 SLFHQRYA-DFAPSLLQVWKKHFEar---------------------keEKTPNITKLRTDLRFIAELTIVGIFtDKE-G 309  human
FlyBase:CG2253-PA  163 SRLHCTYA-DFDVHFLEAWQKALNik---------------------atEKIGNPSKLRVDLRLFAELVSSGVIqMKP-G 219  fruit fly
AAB54133            77 GLLNSKNF-NFGGDVVEKLISEQQd-----------------------LLSKQKYQEAQNLAIFLCDLGNSGVLtA-Q-S 130  Caenorha...
FlyBase:CG7907-PA   91 GLINVADF-EFGSECLLFMAHKVGe-----------------------SVHIRDWNRCRGVVHCMVDLYHCQVLpSSY-I 145  fruit fly
AAD22677            69 GLLNLENE-DFVQKLVESVHANFQv-----------------------ALDSGNCNSIRILLRFMTSLLCSKVIqPAS-L 123  thale cress
CAB11644           104 WALNLRFStAFTGPMLANLYCALYpnpgyslchesyfelkqnenevsEKDRSSHLLKVRPLLRFLIEFWLNGVVgTPE-D 182  fission ...
BAA76378           109 LICNAKNF-VIAKYVIEYLHSKMQtm--------------------lDSQEGSVFNDIKNILKFLSTLTPIIEDn--G-I 164  Candida ...
CAB11293           100 IRASLRVP-LILEKAAAYFCLQYFt----------------------NLNSFLYYEAKVDLRMLICMSFALQPGtLKP-L 155  fission ...
EEU05624           102 MVVNSKNN-VAGKSIINYFFEELQkwckqty----------ndefksTSNETGPWNKIKLILRFLSILSPMFLVdELInI 170  Saccharo...
1H2T_C             126 MVAMFENFVSVTQeedvp-------qvrrdWYVYAFLSSLPWVGKELY-----EKKDAEMDRIFANTESYLKRRqk---- 189  human
BAA92646           310 LSLIYEQLKNIINadr-----------eshTHVSVVISFCRHCGDDIA-----GLVPRKVKSAAEKFNLSFPPSei---- 369  human
FlyBase:CG2253-PA  220 LAQLGVVLVHLIAldk-----------ddhSNFSIILSFCRHCGEEYA-----GLVPQKMQQLATKYGVEVPKSdf---- 279  fruit fly
AAB54133           131 IGEYLESFIAAAFeenmp-------qvrndYYIQTVLRCLPWIGKELT-----EKAPEQMENIGEAIGKYLELRnknhva 198  Caenorha...
FlyBase:CG7907-PA  146 LKLLAAFLKDCEAlkdpddlvgvtpqirrdFLAYCVLSAMPLIGRDLE-------GETAFDKLIVSLQIYIKKRsalhtn 218  fruit fly
AAD22677           124 IVVFETLLSSAATtvdeekgn-pswqpqadFYVICILSSLPWGGSELA-----EQVPDEIERVLVGIQAYLSIRknssts 197  thale cress
CAB11644           183 FVSYLPSTDSNDKkfrkpw-----feeqnlKKPLVVLLFNDLMDTRFGfl-llPVLTSLVRTFSCELFTTEDFEdketle 256  fission ...
BAA76378           165 IQIFKQFLNFAIElqeqt-------evrngLAQEIYYNVLIAIPYVLSnd-nsDDLKKSINELIELARNFKIVAesatvl 236  Candida ...
CAB11293           156 FSLLADAISKETKpsv-----------wgdNFLRIILINLPYFIAANNd----LGKKDFANEILDQCEIYVRHRkssitl 220  fission ...
EEU05624           171 YKSLFELSIELNNldpg---------nrvpLSEAIYTNTLLNIPYLFFfnrnnDGLRTKVEELLAYVEQNYLVKttdinl 241  Saccharo...
1H2T_C             190 -------------tHVPmlqvwtadkphPQEEYLDCLWAQIQKLK 221  human
BAA92646           370 -------------isPE-----------KQQPFQNLLKEYFTSLT 390  human
FlyBase:CG2253-PA  280 -------------ltAD-----------KQLNLRTMLKGYFKALC 300  fruit fly
AAB54133           199 ll-----qvwregsTDQ-----------KQEDYLESLSAQIEALR 227  Caenorhabditis elegans
FlyBase:CG7907-PA  219 ---------mlsvwpDF-----------NQRDYLELLWQQVDGMR 243  fruit fly
AAD22677           198 gln---ffhngefeSSL-----------AEKDFVEDLLDRIQSLA 228  thale cress
CAB11644           257 --------lvnrlnPVV-----------WRTYLRKSLNSYVDKLE 282  fission yeast
BAA76378           237 lpfdtrmgnfelpyIPK-----------QMVDLILPALIKLQNDD 270  Candida albicans
CAB11293           221 sn-----plsihdnLSE-----------EELDLLYKQLILSREND 249  fission yeast
EEU05624           242 lreyngeppyemvelvrvvlpnvkkalinnleqlnelfpdwnhll 286  Saccharomyces cerevisiae JAY291
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