Conserved Protein Domain Family
ABC_drug_resistance_like

?
cd03264: ABC_drug_resistance_like 
ABC-type multidrug transport system, ATPase component
The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Statistics
?
PSSM-Id: 213231
Aligned: 19 rows
Threshold Bit Score: 282.93
Created: 27-Apr-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               ## ###                  
AAO75408    196 VNIERVTGRFaglrrsyfrmvksvpmigkrrkpfkaLRGVSFEIQt-GMFGLLGPNGAGKSTLMRVICGifeQSYGSIWI 274 Bacteroides thet...
YP_054932    61 LQLEGVHFSYprck-------------------srlFTELNLILGdtGPTVLLGLNGAGKTTLLRLCAGefqPSAGLIAV 121 Propionibacteriu...
AAG24830      3 LAVDGLTVRYrkr---------------------vaVDAVSWRLDe-GFHALLGPNGAGKSSLLRAIATlqpTVSGTVEL 60  Propionibacteriu...
YP_056197     6 IELDEVVVRYrsg---------------------wqLGPVSATFPv-GVSALVGPNGAGKTTMLAVLTGikrPRAGTLRR 63  Propionibacteriu...
YP_056757     2 IELKHVSHRYrhr---------------------rsLVDISCEFGs-GLWGLLGPNGAGKSTLLSILATlrePESGHFRV 59  Propionibacteriu...
CAB88481      5 VSASGLSLHYgrt---------------------raLDDVSLRLTp-GVTGLLGPNGAGKTTLLRVLATavpADRGAFTV 62  Streptomyces coe...
BAC68239     27 IQATGLKVRVgrk--------------------rmaVNGVDLSLGt-GVHGLLGPNGAGKTTLIRTLATvlrPTEGTLEM 85  Streptomyces ave...
ZP_00312888   3 LKIEGLSKSYkkk---------------------kaLDSVNLFISn-GIYGLLGPNGAGKTTLMRILAGliaPDEGRIEF 60  Clostridium ther...
CAD47601      3 LQLDNITKSYgkk---------------------ivLNQISYQFTp-GLYGLLGANGTGKTTLLNLMSHftfADSGNIYW 60  Streptococcus ag...
ZP_00312428   3 LKLENITKFYgkq---------------------caLDNFNGVFTe-GIYGLLGPNGAGKTTLINIIIGvleASKGAILL 60  Clostridium ther...
Feature 1                             #                                                         
AAO75408    275 NGldtriyr--eelqslIGFLPQEFGTYENMTSWEFLDYQAILkgivdgdlrrerldyvLKAVHMYERKDEKIGSFSGGM 352 Bacteroides thet...
YP_054932   122 DGgkdp--------rsvVSLMPQQIRPIPGFRVVEQVAYSAWLggcsssqs-ekraimaLEAVQLEDRLKDKPNQLSGGQ 192 Propionibacteriu...
AAG24830     61 DGrsgte------irahLGYCPQENLGRSRFTVREHLAYMCWLhripdsrv-psevdrvIELVDLAERADDRISALSGGM 133 Propionibacteriu...
YP_056197    64 DGqpvrrrregsgyrahIGYVPQECTWSPSWPVEDFLAFCARMyrvpstqv-rhrcqgvMSDLNVGQFAHQPIGTLSGGQ 142 Propionibacteriu...
YP_056757    60 NGvdvsddv--dtirglVGFLPQRFSLPSHFRIRRAVEYAAWArdvepsec-raracaaLDRVGLLDRADERVQSLSGGM 136 Propionibacteriu...
CAB88481     63 LGhdpgssrgrqevrrrLGYLPQTPGFHPDFTAFEFVDYVAILkeladrrerhrevrrvLEEVDLGEVRGRRIKKLSGGM 142 Streptomyces coe...
BAC68239     86 LGesaggmgehralrrrIGYLPQEFGYYKRFTVREFVEYMAWLkevpkadi-paavqraVERVGLADRADERMKALSGGM 164 Streptomyces ave...
ZP_00312888  61 DGedvlknm--dkfrykIGYLPQEFGCYKSITVEECLDTIGVLkgiraper-kkqieqvLAEVNLSNEAKKKVGALSGGM 137 Clostridium ther...
CAD47601     61 NGqeqse-----efyrhIGFLPQHFRYYDQFTGIAFLNYIATLkgvdkkka-kqeiprlLELVGLGDVGKKKISSYSGGM 134 Streptococcus ag...
ZP_00312428  61 DGsdvkkmg--tkyldkVGYLPQEPTFYKNFRVDEFLKYMCAIkgipskhv-dsrieevLELVNLTDSYKKKVGALSGGM 137 Clostridium ther...
Feature 1                          ##                              #                        
AAO75408    353 KQRIGIALILLHLPRILVVDEPTAGLDPRERIRFRNLLVELskdriVIFSTHIIEDISSSCNQVVVINKGELKYFG 428 Bacteroides thetaiot...
YP_054932   193 LRRVGLAQALVGEQPIVLLDEPTAGLDPAQKHVFRNLLTELgatrsFVVSTHDTSDVDSMYNRVVILHEGHIAYDG 268 Propionibacterium ac...
AAG24830    134 RRRVGIGSALVGRPSLVILDEPSAGLDVAQREALSSVLQRVsaeaiTIVSTHIVEDVLDHADTLTVMNQARFAHSG 209 Propionibacterium th...
YP_056197   143 KRRVFLAAALVHDPEVLILDEPTVGLDPGERISFRRHVVEQaasrvVVLSTHLMDDVALSADQVHLVDGGHITWSG 218 Propionibacterium ac...
YP_056757   137 RQRLGIACAIVGDPAVLLLDEPTVGLDPASRIGVRSLFGELaedrtVIVSTHLLEDLQGFVSQLVVLSEGKLIFEG 212 Propionibacterium ac...
CAB88481    143 RQRVALAAALVGDPGFLVLDEPTVGLDPEQRMRFRELIAGAgegrtVLLSTHQTEDVAMLCHRVIVMAAGAVRFDG 218 Streptomyces coelico...
BAC68239    165 VRRVGIAQAIVNDPTILLLDEPTAGLDPAQRLRFRELLQELgtdtcVLVSTHLVEDVAAACTNVVLFAEGRLVFQG 240 Streptomyces avermit...
ZP_00312888 138 RRRLGIAQAMLGNPAFIMVDEPTAGLDPEERIRFRGFIRRVaanrvVLLSTHIIEDIKNNCDGLALINNGKVKQFD 213 Clostridium thermoce...
CAD47601    135 KQRLGIAQALINDPEILILDEPTVGLDPKERVKFRHILSQLstnkiIILSTHIVSDVEAVAKEIIVLKNGKFIEHG 210 Streptococcus agalac...
ZP_00312428 138 RQRLGIGQAILNRPDILILDEPTAGLDPGERIRFRNIISKLskdriVLLATHIVSDVEYIAKEVLILKKGKLVKKG 213 Clostridium thermoce...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap