1KTJ,1AHM


Conserved Protein Domain Family
Der-p2_like
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cd00918: Der-p2_like 
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Several group 2 allergen proteins belong to the ML domain family. They include Dermatophagoides pteronyssinus, group 2 (Der p 2) and D. farinae, group 2 (Der f 2) allergens. These house dust mites cause heavy atopic diseases such as asthma and dermatitis. Although the allergenic properties of these proteins have been well characterized, their biological function in mites is unknown.
Links
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Statistics
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PSSM-Id: 238460
Aligned: 6 rows
Threshold Bit Score: 174.919
Created: 5-Feb-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative lipid
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:putative lipid binding cavity [chemical binding site]
Evidence:
  • Comment:hydrophobic cavity of conserved residues
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  # #                  # # #          # # #          #                 
1KTJ_A      5 VKDCANHEIKKVLVPGCHGsepCIIHRGKPFQLEAVFEANQNTKTaKIEIKASID-GLEVDVPGIDPNACHyMKCPLVKG 83  European house dus...
O02380     20 FTDCGKKEIASVAVDGCEGd-lCVIHKSKPVHVIAEFTANQDTCKiEVKVTGQLN-GLEVPIPGIETDGCKvLKCPLKKG 97  Tyrophagus putresc...
Q965E2     22 FQDCGKGEVESLEVEGCSGd-yCVIHKGKKLDLAISVTSNQDSANlKLDIVADIN-GVQIEVPGVDHDGCHyVKCPIKKG 99  sheep scab mite
Q9U5P7      5 FTDCGHNEIKELSVSNCTGn-yCVIHRGKPLTLDAKFDANQDTASvGLVLTAIIDgDIAIDIPGLETNACKlMKCPIRKG 83  Glycyphagus domest...
Q9NFQ4      5 FKDCGKGEVTELDITDCSGd-fCVIHRGKPLTLEAKFAANQDTTKaTIKVLAKVA-GTPIQVPGLETDGCKfVKCPIKKG 82  Glycyphagus domest...
1AHM        5 VKDCANNEIKKVMVDGCHGsdpCIIHRGKPFTLEALFDANQNTKTaKIEIKASLD-GLEIDVPGIDTNACHfVKCPLVKG 83  American house dus...

Feature 1         # # #   #   #    # # # #       # # #    
1KTJ_A     84 qQYDIKYTWN-VPKIAPKSENVVVTVKVMGdDGVLACAIATHAK 126 European house dust mite
O02380     98 tKYTMNYSVN-VPSVVPNIKTVVKLLATGE-HGVLACGAVNTDV 139 Tyrophagus putrescentiae
Q965E2    100 qHFDVKYTYS-IPAILPTTKAKIIAKIIGD-KGLGGCIVINGEI 141 sheep scab mite
Q9U5P7     84 eHQELIYNIGeIPDATPEIKAKVKAQLIGE-HGVLACGWVDGEV 126 Glycyphagus domesticus
Q9NFQ4     83 dPIDFKYTTT-VPAILPKVKAEVTAELVGD-HGVLACGRFGRQV 124 Glycyphagus domesticus
1AHM       84 qQYDIKYTWN-VPKIAPKSENVVVTVKLIGdNGVLACAIATHGK 126 American house dust mite

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