Conserved Protein Domain Family
ECSIT

?
pfam06239: ECSIT 
Evolutionarily conserved signalling intermediate in Toll pathway
Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1.
Statistics
?
PSSM-Id: 461857
Aligned: 17 rows
Threshold Bit Score: 263.446
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_005994181  86 DDLFKKAagDSRTKATFNRVVDTFCNKNV-RRRGHVEFIYAALKKMPEFGVERDINIYNRILDVFPKEVFVPQNFIQRMF 164
XP_018654473  95 TEI------RKWKKRTFLHILEMFIQRSGpSRKGFTSFIQNALIKMPEYEVTDDLDCYKAVIRLFPTGRMTVKRFLQADF 168
EDX11805      55 RNPFTAA--QDRTKNSYLTMVEIFQERDV-HRRNHVEFIYAALKNMADFGVERDLEVYKALINVMPKGKFIPTNMFQAEF 131
Q17B53        60 TPLFEHV--STKDKKTYIEMVRVFEGRSV-HRRNHVEFIYAALKHMEEFGVHKDLEVYKSLINVMPKGKFIPTNIFQAEF 136 yellow fever mo...
NP_001229867  86 DDIFDRAagDSKTKVEFNRVVDVFKSKDI-RRRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFPKEVFVPQNFIQRMF 164
CAF92631      84 VDLFDHVagEFKTKAMFNKAIDVYVKSDV-RRRGHVEFIYAALKRMPEFGVERDLAVYNKLLDVFPKEVFVPRNFIQRMF 162
XP_023201534  78 EDLFEQVakESKTKATFNQVIDVFTKRDI-RRRGHVEFIYAALKKMPEFGVERDLTVYNKLLDVFPKEVFVPRNFIQRMF 156
XP_002724302  73 EELFKQApgGERDKASFVRAVQCFGQQDV-RRRGHVDFIYLALRKMREFGVQRDLAVYNLLLDVFPKEVFRPRNVFQRMF 151
Q9QZH6        73 EDLFKPSgnRERDKASFLNAVRSFGAHNV-RKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNVIQRIF 151 house mouse
ELV14291      64 EELFRQApgEERDKASFVRAVRSFEQHSV-RKRGHVDFIYLALRKMREFGVERDLAVYNLLLDIFPKEVFKPRNVIQRIF 142
XP_005994181 165 NHYPRQQECGVQVLEQMENYGIMPNKETKFLLVQIFGEKSHPVRKYQRIMYWFPKFKHANPYPVP----AVLPQDPLDLA 240
XP_018654473 169 GHFPKQQQVMIDILNQMSRYHVLPDDEVGQMIIDVFGWRNHAMQTYRRLMYWMPKLYYSNPWTLPlriaDDLDLDPIKLG 248
EDX11805     132 MHYPKQQQCIIDLLEQMEDCGVMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKNLSPWPLP----DPVPDDTLEMA 207
Q17B53       137 MHYPRQQQVIIDLLEQMEDNGVIPDYEMESMLVNVFGKKGHPVRKYWRMMYWMPKFKNLSPWPLP----NPVPDDSLDLA 212 yellow fever mo...
NP_001229867 165 NHYPRQQECGVQVLEQMENYGVMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKHTNPYPVP----HVLPSDPVDLA 240
CAF92631     163 NHYPRQQECGVQILEQMENYGIMPNVETKVLLVQIFGEKSHPMRKYQRILYWFPKFKHLNPFPVP----QELPADPVDLA 238
XP_023201534 157 NHYPRQQECGVQVLEQMESYGIMPNIETKVLLVQIFGEKSHPIRKYQRIMYWFPKFKHVNPFPIP----QPLPEDAVDLA 232
XP_002724302 152 VHYPRQQECGVAVLEQMEQHGVMPDTQTEFLLTQIFGRRSYPMLKLVRMKLWLTRFKNVNPFPVP----LHLPPDPVDLA 227
Q9QZH6       152 VHYPRQQECGVAVLEQMERHGVMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVP----RDLPQDPLDLA 227 house mouse
ELV14291     143 VHYPRQQECGIAVLHQMESHGVMPNKETEFLLVQIFGRRSYPMLKFLRMKLWLTRFKNINPFPVP----HELPQDPVDLA 218
XP_005994181 241 KFSLQRIAA-DLDAKTTVFQMPATDISedgAEVKQPYVVG 279
XP_018654473 249 CLIAERICP-DRMTEFTVVQMPSSN-----SDRLDSLISA 282
EDX11805     208 KLALERMCTvDLRSKITVFETSELKDAi-----dDTWIVS 242
Q17B53       213 KMAVERMCSvDLLSQITLFDTENVPDAi-----dHTWIVS 247 yellow fever mosquito
NP_001229867 241 QFSLTRIAA-DLDAKITIYQYPSTDITetgEEITRPHIVG 279
CAF92631     239 RFSLTRIAD-DLDAEVTVYQVTSTDVSesgEHVSLPHIVG 277
XP_023201534 233 VLSLTRIAN-DLDAKTTVYQLPFTDITesgEEISFPHIVG 271
XP_002724302 228 KLGLRHMEP-DLSARVTVYQMSLPSDPaspEEPAQPHIVG 266
Q9QZH6       228 KLGLRHMEP-DLSAKVTVYQMSLPSDStgmEDPTQPHIVG 266 house mouse
ELV14291     219 RLGLQHMEP-DLSARVTVYQMPLSSDStglADPTQPYIVG 257
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap