Conserved Protein Domain Family
SR-25
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pfam10500: SR-25 
Nuclear RNA-splicing-associated protein
SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissues. At the N-terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localization signals strongly implies that this is a nuclear protein that may contribute to RNA splicing. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1) signalling pathway.
Links
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Statistics
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PSSM-Id: 463119
Aligned: 10 rows
Threshold Bit Score: 165.473
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007239762   5 RSRSRSRERKStsrq--greRRTEKKRRKYSSSSS-SSSSASPSS------------QKKHGrVSNKSms------kDRK 63 
Q66PJ3         7 RKRSRSRSRSR---------GRGSEKRKKKSRKDTsRNCSASTSQ------------GRKAS-TAPGAeaspspcitERS 64  human
EGW14956       7 RKRSRSRSRSRg--------RRGSEKRSKKSSKDAsKNCSASKSP------------GHKACsTSE-----------ERS 55 
Q4V8I5         7 RKRSRSRSRSRg--------RRGSEKRSKRSSKDSsRNCSTSKSQ------------GHKASsTSGVE---------ERS 57  Norway rat
XP_001521084   9 RSRSRSGSRGRp--------ERSKEMRRKRGSKERrRSRSASGSR------------SRRPRaASHKP---------ERS 59 
Q5F4A9         7 RKRSRSSSRSPs--------GSGREKGGARSS-------AASPGP------------RHRLSsAAAREg--------RKK 51  chicken
XP_005989016   3 RSRSRERSRSRtktsscgkgLKRDGKKRSRSSSSSrRSTSLSKKC------------HHSTSpSK------------ERK 58 
Q502P0         3 GSDSDSRSRSR---------NREENKSRSLSSSSA---RRPSPNH------------EKKH----------------EHS 42  zebrafish
XP_604454      7 RKRSRSRSRSR---------GRGSEKKRKKSSKDVrRSCSASRSQ------------SRKASsTSSGAe--------ERS 57 
XP_008516697   7 RKGSRSRSGTR---------ERGSEKRRKKSSKDApRSCSASRSQgrkastvspgaeASPSPcIT------------ERS 65  Przewalski's horse

XP_007239762  64 TERKKQKRRRSSSSSSSSSSSSSSSSISSSSSTSSSde----eAKKKKKHRMTKKRLKKMka--kkKKKEKKEKKr-lKk 136
Q66PJ3        65 KQKARRRTRSSSSSSSSSSSSSSSSSSSSSSSSSDG-------RKKRGKYKDKRRKKKKK------RKKLKKKGK---E- 127 human
EGW14956      56 KHKARRTAR-----SSSSSSSSSSSSSASSSSSSDG-------RKKRGKNKDKKRKKKKKr-----KKKLKRKGK---E- 114
Q4V8I5        58 KHKAQRTSR--SSSSSSSSSSSSSSSSTSSSSSSDG-------RKKRGKHKDKKKRKKKKk----rKKKMKRKGK---E- 120 Norway rat
XP_001521084  60 KDRGRKRRRPSSSSSSTSSSSSSSSSSSSSSRSSSGg------RKKRSKRKDKKRRKKKKkk---aKKKVKKKCR---Ek 127
Q5F4A9        52 EGRKKKKRKAKASSSDRSSSSRSSSSSSSTSSSDSDtrakqhsRRKRGKHKDKKKKKKMK-------KKLKKKSK---Er 121 chicken
XP_005989016  59 PEKKKAKRKPSASTSSDSSSPASSTSTCSSSLSDSDtes-kesKQQKGKNKTKKSKKKSKkmnrksKKMKKKKAK---Ea 134
Q502P0        43 SEKKKMKRRRSSSSSSSSSSPSPS-------------------REKKAKKKKKRREAKKLkrekkkEKKEKKRQKklaLk 103 zebrafish
XP_604454     58 KHKARRRPR-SSSSSSSSSSSSSSSSSSSSSSSSDG-------RKKRGKHKDKKRKKKKKk----rKKKLKKRGK---E- 121
XP_008516697  66 KHKARRRPR--SSSSSSSSSSSSSSSSSSSSSSSDG-------RKKRGKHKDKKRKKKKKr-----KKRLKKKGK---E- 127 Przewalski's horse

XP_007239762 137 iKKLA-AKAEKVATKApliipvpgsvqvektqsyLETWQNDDAAE-HGPVMTDEQKASFSTKRPMTKEEYEARQSVIRRV 214
Q66PJ3       128 -KAEA-QQVEALPGPS------------------LDQWHRSAGEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSIIRKV 187 human
EGW14956     115 -KAVVlHPAEALPGPS------------------LDQWHKSAGED-DGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKV 174
Q4V8I5       121 -KAVVvHQAEALPGPS------------------LDQWHRSAGEDnDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKV 181 Norway rat
XP_001521084 128 gEAGT-QSPQGMPGPS------------------LDQWQKEPLEE-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVVRKV 187
Q5F4A9       122 vKEER-GVSEALPGPS------------------LELWQKEPLAD-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRV 181 chicken
XP_005989016 135 pTAAK-PKLSKMAGPS------------------VEQWQRETWVE-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRV 194
Q502P0       104 aERAA-ALTASVPAPVpeek----------pqtyLKTWQSEETKE-HGPAMTDEQKAKLSTRRPLTKEEYEARQSVIRRV 171 zebrafish
XP_604454    122 -KARM-QQTEALPGPS------------------LDQWHRAAKEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKV 181
XP_008516697 128 -KAKV-QQAEALPGPS------------------LDQWHRAAEEEeHGPVLTDEQKTRIQAMKPMTKEEWDARQSVIRKV 187 Przewalski's horse

XP_007239762 215 TDPETGRTRLIRGDGEVLEEIVSKERHKDINK----------------------------QSTKADGTTFQKRLGI 262
Q66PJ3       188 VDPETGRTRLIKGDGEVLEEIVTKERHREINK----------------------------QATRGDCLAFQMRAGL 235 human
EGW14956     175 VDPETGRTRLIKGDGEVLEEIVTKERHREINKvgvtalamlcprcvytqylmlltcflpqQATRGDGLAFQMRAGL 250
Q4V8I5       182 VDPETGRTRLIKGDGEVLEEIVTKERHREINK----------------------------QATRGDGLAFQMRAGL 229 Norway rat
XP_001521084 188 VDPETGRTRLIKGDGEILEEIVTKERHKEINK----------------------------QATRGDGLAFQLRAGL 235
Q5F4A9       182 VDPETGRTRLIKGDGEVLEEIVSKERHKEINK----------------------------QATRGDGLAFQVRTGM 229 chicken
XP_005989016 195 VDPETRRTRLVKGDGEILEEIVSRERHKEINR----------------------------QATVGDGVSFQTRMGL 242
Q502P0       172 LDPETGRTRLIRGDGEILEEIVSKERHKDINK----------------------------QSTRGDGDAFQKRLGI 219 zebrafish
XP_604454    182 VDPETGRTRLIKGDGEVLEEIVTKERHREINK----------------------------QATRGDGLAFQMRAGL 229
XP_008516697 188 VDPETGRTRLIKGDGEVLEEIVTKERHREINK----------------------------QATRGDGLAFQLRAGL 235 Przewalski's horse
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