Conserved Protein Domain Family
GT29_ST6GALNAC6
?
cd23978: GT29_ST6GALNAC6 
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).
Links
?
Statistics
?
PSSM-Id: 467706
Aligned: 6 rows
Threshold Bit Score: 462.402
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
?
Aligned Rows:
Download Cn3D
 
putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1               ###                    ##                    #                           
Q969X2       105 CHQCVIVSSSSHllgtklGPEIERAECTIRMNdAPTTGYsaDVGnKTTYRVVAHssvfrvlrrp-qefvnrtpeTVFIFW 183 Homo sapiens
XP_014342309  76 CQECALITSSSHllgsnmGLEIDQSECTIRMNdAPTTGYekYVGsKTTIRVVAHssvyrvlrkp-qeflnktseMMLIFW 154 coelacanth
NP_001165302  71 CNSCVIVTSSSHllntdlGPKINQAECIIRMNdAPTTGYekDVGnKTTFRVVAHssvyrvlrrp-qeflsrfpgQTLIFW 149 tropical clawed...
NP_001265787  75 CHNCALITSSSHvlgsqaGNEIDQTECVIRMNdAPTLGYgsDVGnRTTLRVVAHasvfrvvrrptdflqnlgsnSTIIFW 154 Japanese medaka
XP_007898509  73 CSQCALISSSSQtlgtslGSEIDQTECIIRMNdAPITGYeeDIGnRTTLRVVAHssisqflkrr-keflqrgqeTIFIFW 151 elephant shark
OXB69157      72 CHQCAIVTSSSHllgtrlGAEIDQTECTIRMNdAPTTGYeaDVGnKTTFRVVAHssvyrvlkrp-qefvnktpeTVLIFW 150 scaled quail

Feature 1                                                                    ###                 
Q969X2       184 GPPskmqkpqgsl-vrviqraglvFPNMEAYAVSpGRMRQFDDLFRGETGKDRekshSWLSTGWFTMVIAVElCDHVHVY 262 Homo sapiens
XP_014342309 155 GPPnkmqqekkgtlfrliqkasmtFPSLSTFIISpQKMRQFDDLFRDETGRDRkksrSWLSTGWFTMVIAVElCDRIHVY 234 coelacanth
NP_001165302 150 GPPnkmqqgsksnmyhiiqrassaFPNVSAFVVSpRNMGRFDELFRAETGRDRakshSWLSTGWFTMVIAVElCNNVHVY 229 tropical clawed...
NP_001265787 155 GPPnkigkdakgtlyrliqrvsmtYRNVTFFSISpNKMRKFDNLFQRETGRDRqkshSWLSTGWFTMVIAIEiCDNIKVY 234 Japanese medaka
XP_007898509 152 GPYsrmrrdgksnvfriikqeiaiGANMSVFTVSpKRMKQFDDLFQMETGQDRkqshSWLSTGWFTMVIAVGiCDSLHVY 231 elephant shark
OXB69157     151 GPPakmqkgllk----iiqrvgasFPNMTAYVVSpRRMKQFDELFRGETGKDReksrSWLSTGWFTMGIAVElCDTVHVY 226 scaled quail

Feature 1        ##               ###                        #                         
Q969X2       263 GMVPPNYCSqrprlqrMPYHYYEPKGPDECVTYIQNEHsrkgnhHRFITEKRVFSSWAQLYGITFSHPSW 332 Homo sapiens
XP_014342309 235 GMVPPNYCSqrplpkkMAYHYYEPKGPDECTTYLQNERgwkgnhHRFITEKKVYARWARRYNITFSNPKW 304 coelacanth
NP_001165302 230 GMVPPNYCSkrq--rkMPYHYYEPKSPDECITYIQNEQgrrgnhHRFITEKLVFARWAPVYNITFSHPEW 297 tropical clawed frog
NP_001265787 235 GMVPPNYCGknttskkMPYHYYKPRGGDECVMYMQNEGgrrgnhHRFITEKQVFARWAKQYNITFTHPKW 304 Japanese medaka
XP_007898509 232 GMIPYNHCRkph-hknLPYHYYNTKSNDECATYLTHEHarmgnhHRFITEKHVFARWAEHYNITFSHPSW 300 elephant shark
OXB69157     227 GMVPPNYCSqrpqprrMAYHYYEPKGPDECTTYIHNERsrrgnhHRFITEKRVFASWAAPYNITFSHPTW 296 scaled quail

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap