Conserved Protein Domain Family
PUMA
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pfam15826: PUMA 
Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
PUMA (p53 upregulated modulator of apoptosis) is a family of eukaryotic proteins that are a target for activation by p53. The proteins contain BH3 domains and are induced in cells after p53 activation. They bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of apoptosis.
Links
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Statistics
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PSSM-Id: 374148
Aligned: 4 rows
Threshold Bit Score: 212.122
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_012666623   2 ARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGLPAAPAAPALLPA--AYLCAPTAPPAVTATLGGPRWP- 78 
1_pfamImport   1 ARARQEGSSPEPVEGLSRDGPRPFPLSRLVPSAVSCGLWESDCSPRVAAHGLFRAgaAAVSQPPPPPVWVSLTSQRTIV- 79 
2_pfamImport   1 ARARQEGSSPEPVEGLARESPRPFPLGSLVPSAVSCGLCEPGL-PRVAGPRLLPGprTQLF-PSPSPVWVSDLSGLQLEr 78 
XP_001373110   2 ARAQQDGSSPEPVEGLPRESPRTFPLGRLMPSAVSCSLCEAGLNP--SGDSMCPApgPALAPSSLLPLAYFCTRQPRAY- 78 

XP_012666623  79 GGPRSRPRGPR-LDGPQ------PSLLP----------AEQHLESPVpstpgalAGGPTQAAPEVRGEE-----EQWARE 136
1_pfamImport  80 GGSVGRARGLL-FPGPQ------PSLSP----------AEPHLESPVpsapgalAGGPTQAAPGVRGEE-----EQWARE 137
2_pfamImport  79 GGAEWEDRAPRpLSGPQ------PSLSP----------AEQHLESPV----------PTQAAPGVRGED-----EQWARE 127
XP_001373110  79 GGPRWARAARSpAAGNQgqsgslPSLGPrsaqeeggqeGEPQGASPM-------SGGP----PGVLGPEhgdqgEQQDRE 147

XP_012666623 137 IGAQLRRMADDLNAQYERR-RQEEQQRHRPSPWRVLYNLIMGLLPLPRGHRAPEMEPN 193
1_pfamImport 138 IGAQLRRMADDLNALYERR-RQEEQQRHRPSPWRVLYNLIMGLLPLPRGRGAPEMEPN 194
2_pfamImport 128 IGAQFRRKADDLYALYERSvRQEEQHRHRPSPWRVLYNLIMGLLPLPRDHGAPEMEPN 185
XP_001373110 148 IGAQLRRMADDLNALYEQRrREEEQRRHL-SPWRLLYNLISGLLAPQRRNRMPDVEPN 204
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