3FLO,6HV9,6V8P


Conserved Protein Domain Family
DNA_pol_E_B

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pfam04042: DNA_pol_E_B 
DNA polymerase alpha/epsilon subunit B
This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure.
Statistics
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PSSM-Id: 461142
Aligned: 25 rows
Threshold Bit Score: 140.907
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3FLO_G       150 VIVTCGPYFAn---DNFS----LELLQEFIDSIN--------NEVKPHVLIMFGPFIDITHPLIASGKLPnfpq------ 208 baker's yeast
Q7Q7P2       284 LVFLSDCWLD----NPIV----MEKLEQLLRGYD---------DFPPVAIVLMGPFARSIENVY---------------- 330 Anopheles gambi...
Q9VRQ7       286 IVFLSDVRLD----LPVV----MEKLRQLFVGYD---------SCPPQAIVLMGPFTASTRNHH---------------- 332 fruit fly
XP_001706598 182 VLFVAGMDLGwe---------aSHAARAVLFATAlg----tpPFSSVKQVVLCGGTYAPVDAGPAAAACLgn-------- 240
Q19366       186 IAFVSGLDLTgdleDDRLtisgLEFMADWMNVQVgn----enQCPPIDRLVVIGPLVETKSNGCDVQSVVrtlt------ 255 Caenorhabditis ...
6V8P_F       221 IALVSGLNLNn---TSPDrllrLEILREFLMGRInnk---idDISLIGRLLICGNSVDFDIKSV---------------- 278 Saccharomyces c...
Q9W088       175 LVLASGLDQLq---AHKFve-aLNLFQYWLAGSLgn----nkEAGSMVRLIVAGNSVRASAMAHVPTLQVar-------- 238 fruit fly
O48520       182 VVLLSGLCIGs---KSANpl-qFQLLVDHITGHLgdee-eqgLAAQIVHVVIAGNSFEFPRKLINGQNLAs--------- 247 thale cress
O35654       196 VLLVSGLGLGg---GGGEsllgTQLLVDVVTGQLgdeg-eqcSAAHVSRVILAGNLLSHNTQSRDSINKAkyl------- 264 house mouse
EAA31874     231 IALVSGLEFSn---ADTSyameLNLLLEYLLGEAldpsvqrdELSHITRLIIAGNSISTTAAEQAKPAAAfdtttvtnkf 307
3FLO_G       209 ------fktQPKTLDELFLKLFTPILKTIS----PHIQTVLIPSTKDAISNhAAYPQASLIRKALQLPKRN--------- 269 baker's yeast
Q7Q7P2       331 ----------TLKGHFVKLGEILSSCEKLK----SQTDLVIVPSIDDPAAA-NILPRPPVPEALAGELKKRfp------- 388 Anopheles gambi...
Q9VRQ7       333 ----------ELRHHLDALGGLAAGCEQLK----KQTDLILVPSSEDPTAP-NILPRAPIPECLAAGLLKAwp------- 390 fruit fly
XP_001706598 241 --------aLSPTTGFLDLQASYDLVDTILarvaAARPTILVPGQSDPTPR--LWPQAPVPSIVLPRCSLTn-------- 302
Q19366       256 ------lsrAEKHSSTASLITVDKIINSIAek-pLVNTVDVTPGVGDPCSS--MWPLPPIHRVCLPRCGMSdk------- 319 Caenorhabditis ...
6V8P_F       279 ----------NKDELMISLTEFSKFLHNIL----PSISVDIMPGTNDPSDK--SLPQQPFHKSLFDKSLESyfngs---- 338 Saccharomyces c...
Q9W088       239 -------tqANANDTVQAVSQLDQWFASWA----RSLPVDIMPGPYDPANF--MLPQQPFHKCMFPQAAQLa-------- 297 fruit fly
O48520       248 ---------KDQSTLYEPIKELDIMLSQIA----AGVSVDIMPGTNDPANF--ALPQQPLNRCLFPGSSPYn-------- 304 thale cress
O35654       265 -------tkKTQAASVEAVKMLDEILLQLS----ASVPVDVMPGEFDPTNY--TLPQQPLHPCMFPLATAYs-------- 323 house mouse
EAA31874     308 qpqikkygyDSSSYNPVPSQLLDSFLSDLL----PTMPVTLLPGALDPANA--SYPQQPIHPAMFPQSRTYmpppkagag 381
3FLO_G       270 -------------FKCMANPSSFQINEIYFGCSNVDTFKDLKEVIKGGTTS-----------------SRYRLDRVSEHI 319 baker's yeast
Q7Q7P2       389 ------------rTILTTNPCRLQYCTQQIVVCRADLVTKLCRNTIHFPK------------------EGLLEEHFARTI 438 Anopheles gambi...
Q9VRQ7       391 ------------rTQLATNPCRLQYCTQQIVVCRLDLMAKFCRNTLHFPED-----------------TSQIEQHFARTI 441 fruit fly
XP_001706598 303 ------------sLISAPCPAKLLTRDKQLVWVIDGTVLTYLAALIPASLT---------------------VPALVATL 349
Q19366       320 ------------kVNLVTNPYEFEVNGLRVMTMSGENVSELLRTSLKWTG-----------------------ADAIENI 364 Caenorhabditis ...
6V8P_F       339 ---------nkeiLNLVTNPYEFSYNGVDVLAVSGKNINDICKYVIPSNDNgesenkveegesndfkdDIEHRLDLMECT 409 Saccharomyces c...
Q9W088       298 ------------tFQAVTNPYSCRLDEALVVGTSGQNVSDLLRSTSLDSA-----------------------LEALRCT 342 fruit fly
O48520       305 ------------tFRSCTNPHSFDVDNIRFLGTSGQNIDDLGKYSEAKSK-----------------------LDFVERT 349 thale cress
O35654       324 ------------tLQLVTNPYQATIDGVRFLGTSGQNVSDIFRYSSMEDH-----------------------LEILEWT 368 house mouse
EAA31874     382 kdrdvpgeeepgwFDNVTNPWEGEIEGWRVLGTGGQNLDDVFKYVESEDR-----------------------LGMMEAM 438
3FLO_G       320 LQQRRYYPIFPgsirtrikpkdvstkketndmeskeekvyehisgADLDVSYLGLTEFVG-GFSPDIMIIPS-ELQHFAR 397 baker's yeast
Q7Q7P2       439 INQNTLAPLTP----------------------------------IAFPTHWNYDAALSL-YPLPDLIVIGD-PCQGFHT 482 Anopheles gambi...
Q9VRQ7       442 VCQGHLVPIHP----------------------------------IAMPVHWDYDPALWL-YPLPDLIVMGD-SCQSFSS 485 fruit fly
XP_001706598 350 LQVAHLCPQSP----------------------------------LFFDVQPLQLDAFVLdEP-PQYIVVSN--HPQTTT 392
Q19366       365 IKWQHVAPNCPd---------------------------------TLDAFPVAERDPLIM-DITPHVIICGNqPHAEFRH 410 Caenorhabditis ...
6V8P_F       410 MKWQNIAPTAPd---------------------------------TLWCYPYTDKDPFVL-DKWPHVYIVAN--QPYFGT 453 Saccharomyces c...
Q9W088       343 LTWGHVAPTAPd---------------------------------TLACYPYIESDPFIL-RECPHVYYAGN--CESFAT 386 fruit fly
O48520       350 LRWRHLAPTAPn---------------------------------TLGCYPFTDRDPFLI-ETCPHVYFVGN--QDKYDN 393 thale cress
O35654       369 LRVRHISPTAPd---------------------------------TLGCYPFYKTDPFIF-PECPHVYFCGN--TPSFGS 412 house mouse
EAA31874     439 CRWRCVAPTAPd---------------------------------TLWSYPFQEDEPFVI-KECPHLFFVGC--QPEFGT 482
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