Conserved Protein Domain Family
PBP4_Staph

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NF038258: PBP4_Staph 
penicillin-binding protein PBP4
Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Statistics
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PSSM-Id: 468436
Aligned: 20 rows
Threshold Bit Score: 512.985
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_002459826      8 LILVLVSFTQFTPYLFAAESdavlSPSQIATQYGYTGITAAYDPEGAINVSQTGQILYNYHGNKKWYLASMTKLMTMYLT 87  Staphylococcus
1_ncbifamImport   1 IIILCLTLSIMTPYAQATNSd--vTPVQAANQYGYAGLSAAYEPTSAVNVSQTGQLLYQYNIDTKWNPASMTKLMTMYLT 78 
WP_016930899      8 ILVALLTIAIIAPKTYASEYe--pTPTEIARQYGYPNVTDAYQPEGSINVSQTGQILYDYQSNQKWYPASMTKLMTMYLT 85  Staphylococcus
WP_002508967      8 MVTVMFIASIITPFANAETAt----PTSIANQYGYN-VSDKYQPEGAANIAQTGQILYDYNIDKKWYPASMSKLMTMYLT 82  Staphylococc...
WP_015899549      8 TLLIFFASTIITPFSEADTNt--pSPAQVANEYGYN-ISDDFNPEGAVNISQTGQVLYDYHMDKKWYPASMTKLMTMYLT 84  Staphylococc...
WP_019166222      8 IVVVFFASTIITPFARAYTPt----PVELAQQSGYP-VTWAYQPEGMINISQTGQILYTFQSEQQWYPASMTKLMTMYLT 82  Staphylococc...
WP_002434992      9 TGTIGLTSLLL-TSQSYAVE----KPTPLVNKEENANISTQYEPQSLTLTTKQGQILYNYNENKKVDPASLTKMMTMYLT 83  Staphylococc...
WP_002494751      8 VSALTAALVIS-SPLAHAIDeq-sSPVANVNKDG-LDLSEQYNPKGMIVTNSNGQILYNYHGNTSGDPASMTKLMTLYLT 84  Staphylococcus
WP_002503813     11 TSLIATTLIMG-SPMAQATDvh-qSPIQNVNEQG-LNLSQQYEPKAMTITDENGQVLYDYHGETSSDPASITKLMTLYLT 87  Staphylococcus
WP_019469235      9 MLSWLLTLTAIAPTATITAEt-------EKSASP--KQSVKYKPESFSVIAQTGQILYQDKAEKVTDPASLTKMMTMYLT 79  Staphylococc...
WP_002459826     88 LEAVKKGDLSLDDKVKITQNHYRMSTLPELSNTKLYPGEVYTIAELLQITVSNSSNAAALILANKVSGNVTSFTKLMNKK 167 Staphylococcus
1_ncbifamImport  79 LEAVNKGQLSLDDTVTMTNKEYIMSTLPELSNTKLYPGQVWTIADLLQITVSNSSNAAALILAKKVSKNTSDFVDLMNNK 158
WP_016930899     86 LEAINKGELSLNDKVHITDQHYRMSTLPELSNTKLYPGETYTISELLQITVSNSSNAAALILADEVSGNVNDFTDLMNKK 165 Staphylococcus
WP_002508967     83 LEAVKKGDLSLDDKVKITEDHYRMSTLPKLSNTKLYPGETYTIKELLQITVSASSNAAALILANEVSKNTSEFTDLMNKK 162 Staphylococc...
WP_015899549     85 LEAVKAHKLSLNDKVKITEDDYRMSTLPKLSNTKLYPGETYTIKELLQITVSASSNAAALILAKKVSGNTSDFTDKMNKK 164 Staphylococc...
WP_019166222     83 LQAVKEKKLSLNDTVQITDQHYRMSTLPELSNTKLYPGETYTIAELLQITVSASSNAAALILANQVSDNTSDFVDKMNDT 162 Staphylococc...
WP_002434992     84 LDAVKSGKIHMKDKIKITSKQAQLSQKSNLSSVPLEAGQTYTVKDILSQTALASSNAAALILGEKVSGSTSTFTDKMNQQ 163 Staphylococc...
WP_002494751     85 FDALEKNQIKKNQTIKMTDGDEKVSTLPNLSTFKLKKGQTYTVDEIIKQMTLASSNPATLILGRTIYGDTSKFTDHMNEK 164 Staphylococcus
WP_002503813     88 FDALNNGKISKDQKIKITSDYEKMSALPNLSTVKLKKGQTYTIDEIMKQVSLASSNPATLILGEKIDGSTSKFTDRMNEK 167 Staphylococcus
WP_019469235     80 LDAIENGEIKGTDKIKITSDYEKMSVLPDLASVPLERGKSYSINQFLRQITLESSNAATLILGEKVSGSTSKFTDEMNHK 159 Staphylococc...
WP_002459826    168 AKELGMTHTYFTNPTGAENTQLQEFAPKLTTNDNNSTSTAKDYAILDQHVIADTPNILHFTKQLAPTQHGVTYYTFNHSL 247 Staphylococcus
1_ncbifamImport 159 AKAIGMKNTHFVNPTGAENSRLRTFAPTKYKDQERTVTTARDYAILDLHVIKETPKILDFTKQLAPTTHAVTYYTFNFSL 238
WP_016930899    166 AKALGMSNTHFVNPTGAENSQLKDFAPSKYKDQDNSTSTAKDFAILDHHVIKETPKILHFTKQLAPTQHGVTYYTFNHSL 245 Staphylococcus
WP_002508967    163 AKSIGMKDTHFVNPTGADNALLEDFAPKKYTDEDNSVSSTRDFEILSQRSIQDTPKILYFTKQTAPTQHGVTYYTFNHSL 242 Staphylococc...
WP_015899549    165 AKELGMTKTHYVNPTGAENNLLQDFAPKKYKNEMSSRASAKDYAILSQRVIQDTPKILYFTKQLAPTQHGVTYYTFNWSL 244 Staphylococc...
WP_019166222    163 AKSLGMTHTHYVNPTGAENRLLLEFAPKKYQHESSSTSSARDYAILAQHVVKDTPKILYFTKQIAPTQHGVTYYTFNDLL 242 Staphylococc...
WP_002434992    164 AKTFHMKDTHFTSPAGADTELLGSSAPQKYKNQGKTSSTSKDMNIMMYHMIKEHPEILKTTQNKSDTQKGQSFESTNLSL 243 Staphylococc...
WP_002494751    165 AKSIGMTHTHFTNPSGAPNELLKPYAPTKYQDESKTKTTSEDMSILVRSLLKKHPDVLQYTKLTQGKQYNQSFETTNLSL 244 Staphylococcus
WP_002503813    168 AKELGMNHTHFTNPSGASNDLLKPYEPKKYKDEAKTKTTSQDISLLIHSLLKKHPEVINYTKLTHGKQYNQDFETTNLSL 247 Staphylococcus
WP_019469235    160 AKKLGMDHTHFVNPTGADNHLLQHYAPKQYQKERKTQTTANDMTILMQSILKDHPKILKYSSKTTDKQFGTELKTKNISL 239 Staphylococc...
WP_002459826    248 EGASLSLPGTDGLKTGSSDIAnYNHTITTKRGKFRINQVILGVGDYNNLGGEKERNKMGNAIMESSFNQYAYKKVLSKGE 327 Staphylococcus
1_ncbifamImport 239 EGAKMSLPGTDGLKTGSSDTAnYNHTITTKRGKFRINQVIMGAGDYKNLGGEKQRNMMGNALMERSFDQYKYVKILSKGE 318
WP_016930899    246 EGADMSLPGTDGLKTGSSDVAdYNHTITTKRKQFRINQVIMGAGDYVNLGGEKQRNMMGNAMMNRSFDQYRYKNVLSKGT 325 Staphylococcus
WP_002508967    243 EGGDMSLEGTDGLKTGSSDLAnYNHTITTKRDGFRIVQTIMGAGNYDNFGGEKQRNMMGNAMMNMSFDQYKYTKILGKGE 322 Staphylococc...
WP_015899549    245 EGAELGLKGTDGLKTGSSDIAdYNHTITTKRDGFRIDQAIMGAGDFKHLGGEKERNKMGNSIMNRSFDQYKYVKILSKGE 324 Staphylococc...
WP_019166222    243 EGGNMSLPGTDGLKTGSSDIAdYNNSLTTKRGKFRIFHIIMGAGDYKHLGGEKQRNMMSASAINYTFSQYDYKKILSKGK 322 Staphylococc...
WP_002434992    244 KGQPKYYKGTDGLKTGTSDSG-YSLALTNKQHGLRLNETILDVTPYPSETAKLNRNEIANDMMKYYRKQYEYKKVLSKGE 322 Staphylococc...
WP_002494751    245 KGEPEEYKGTDGLKTGTSDEG-YSLALTNNQNNLRLNAILLDVNPFPSETTKHVRNQIANHMIDDLRKEYVYKKVVDKGV 323 Staphylococcus
WP_002503813    248 KGEPEEYLGTDGLKTGTSDEG-YSIALTNNQDHLRLNATILDVKPYPSEQAKHVRNQIANHMIEDLRKEYTYTKVMSKGT 326 Staphylococcus
WP_019469235    240 KGQRFELKGADGLKTGTSDEG-YSLALTSKRNGLRLNEAILNVKPFPSMKAKNARHKIANAIMNKQFNKYEYRKVLSEGE 318 Staphylococc...
WP_002459826    328 HNINGKTYYIKKDLYDVVPKTLHAKDYQFVInDGEVHLDYKRQFISKQyGPP 379 Staphylococcus
1_ncbifamImport 319 QRINGKKYYVENDLYDVLPSDFSKKDYKLVVeDGKVHADYPREFINKDyGPP 370
WP_016930899    326 HKINGKTYYVKENLYDVVPKDMNQKDYKFIIkDGKVHLDYDRQFLTKDdGPP 377 Staphylococcus
WP_002508967    323 HKINGKTYYLEDDLYDVLPKDFTKEDYKYVIeDKKLHIEYDRSFISDKyGPP 374 Staphylococcus arlettae
WP_015899549    325 QKINGKKYYVKKDLYDVLPKNYTKKDYKFVVeDGKVHIDYPRQFISKKyGPP 376 Staphylococcus carnosus
WP_019166222    323 HKIDGKSYYVTEDLYDVVPKDMAEP-YHLVVkDSQVHLDYPRKFITKNdGPP 373 Staphylococcus delphini
WP_002434992    323 HQIDGKKYTVKKDLYDVVPK-HKKWYIAIND-KGNAYVHYQRHFLDGA-SYP 371 Staphylococcus capitis
WP_002494751    324 HKIDGKKVKIKKALYDTVPKDENKWNLKMND-QDQVYVSYPRHFIKGS-HVP 373 Staphylococcus
WP_002503813    327 HKIDGKEITVSKDLYDTVPKNKDKWSLKVNK-DNQVYVSYPRKFIKGS-HYP 376 Staphylococcus
WP_019469235    319 HEINGKTYQVKQDLYDVVPKKMDHLKFNVNK-EGKVYVAYKRQFIKGT-HAP 368 Staphylococcus cohnii
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