Conserved Protein Domain Family
bHLHzip_Mlx
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cd19687: bHLHzip_Mlx 
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins
Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.
Links
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Statistics
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PSSM-Id: 381530
Aligned: 20 rows
Threshold Bit Score: 111.359
Created: 9-Oct-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLHzip mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Homo sapiens Max (1NLW)-Mad basic region binds the DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # ### ### ##   #                          ##                                
Q9UH92       129 RRRRAHTQAEQKRRDAIKRGYDDLQTIVPtcqqqdf-sigsqklSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDV 205 human
NP_001071841  63 RRREAHTQAEKKRREAIRKGYDELQLIVPnlvqqad-vigsqklSKAVILQRSLNYVEFLQQQKKKQIEELNQLRKEK 139 Ciona intestinalis
XP_001638237  42 NRRFAHSVAEQKRRDAIKKGYDDLQSIVPtcqhsts--agspklSKAIILQRTIEYVSFMHHQRKKHEEELEKLRKEV 117 starlet sea anemone
NP_651556     71 RRREAHTQAEQKRRDAIKKGYDSLQELVPrcqpnd---ssgyklSKALILQKSIEYIGYLNQQKLKQEDEGSALQKEV 145 fruit fly
ELU14074      89 RRREAHTQAEQKRRDAIKKGYEDLQNVVPmcqqpda--lgsqklSKAAILQKSIDYVQYLIQQKKKQEEEVESLRKEV 164 Capitella teleta
OCT59829      44 RRRRAHTQAEQKRRDAIKKGYDDLQCIVPtcqqqdi-aigtqklSKAVVLQKTIDYIQFLNKEKKKQEDDVSKLRKEV 120 African clawed frog
AAH95807      77 RRRHAHTQAEQKRRDAIKKGYDDLQSIVPtcqqqsdfsmatqkmSKATVLQKTIDYIQFLHKEKKKQEEDVSTLRKEV 154 zebrafish
OTF72007      34 RRREAHTQAEQKRRDAIKKGYEDLQMLVPtctqqda--vssyklSKAAILQRSIEYIQTLQQQKHKREKELQLLRKEV 109 Euroglyphus maynei
XP_007899656  95 RRRQAHTQAEQKRRDAIKKGYDDLQAIVPtclqqdf-aigsqklSKATVLQKTIDYIQFLHKEKKKQEEERSTLRKDV 171 elephant shark
XP_005994084  89 HRRQAHIQSEQKRRNAIRKGYEDLQAIVPtcqqpdf-sigsqklSKATVLQKTIDYIQFLHKEKKKQEEEVSTLRKDV 165 coelacanth

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