Conserved Protein Domain Family
LZ3wCH

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pfam18517: LZ3wCH 
Leucine zipper with capping helix domain
This domain is found at the C-terminal region of Hop2 and Mnd1 proteins. In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex. Hop2 (for homologous pairing; also known as TBPIP) is expressed specifically during meiosis, same as Mnd1 (for meiotic nuclear divisions 1). The C-terminal region of both Hop2 and Mnd1, folds into three alpha-helices that are interrupted by two short non-helical regions. These alpha-helices of the two proteins together form a parallel coiled coil that provides the major interface for heterodimer formation. The non-helical regions form substantially kinked junctions between adjacent leucine zippers: the LZ1-LZ2 and LZ2-LZ3 junctions.This domain is the C-terminal segment of Hop2 and Mnd1 which folds back onto the C-terminal leucine zipper (LZ3) to form a helical bundle-like structure, hence designated LZ3wCH (for LZ3 with capping helices). The LZ3wCH region plays a role in interacting with the Dmc1 nucleofilament.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

pfam18517 is the only member of the superfamily cl39841
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002505091 148 AVLETIRGGKENCHEAVNRWTD---NTFLLKSWVEKKCG-DRe-QAAKFFkehGVNfNNFDYL 205
GAO48130     119 ITPAERKQIDTDYHNMRKEWQKrrkWFKNLWGMIEEGSGmTEakELFERL---G---IEEDDV 175
KXN70301     155 VTDEEKVIIDKNYSDYRKHWKTyknKFKDIFDIISENLTvSNk-DFMEEQ---GIE-TDEDFG 212
XP_016611756 158 LSAEDRKRIDKNLEAMQKEWRKrkrMFNDMWAAVTENIQgSLa-EFRETV---GVE-TDEAAG 215
XP_011395969 120 VSAEDVAAAEQRFATGLTAWERyrrMFRDIWDTVSENLEaNQa-DVFEDM---GVE-TDEAIG 177
XP_001695346 147 ITAEERAAAEKALARTLEAWRKrrsMFKNIWGAISENMDgKQa-DLFEEI---GVE-TDEAAG 204
XP_002955362 147 VTPEERAAVEKSLTTNLGWWRKrraMFKNIWSTISEGLDgKQk-DLFEEI---GIE-TDEAAG 204
XP_013905419 143 VTADERAAVEKAFVAAMDAWRKrrgIFRGIWDTISEGLEgKQa-DLFEEI---GVD-TDEAAG 200
XP_653175    153 IDPKEKAKLLKDNEFFVKEWKKrkrICKDASELLTESSGmKIs-KLYETL---GIE-TDEQNG 210
XP_005704272 153 IDPEERKKLQQNLLYNVSNWKQrkrMAKDILDAISENANlKYk-ELCEQI---GVE-TDETVG 210
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