Conserved Protein Domain Family
ZZ_PCMF_like
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cd02338: ZZ_PCMF_like 
Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel modulatory factor 1 or FIGC has been shown to possess intrinsic E3 ubiquitin ligase activity and to promote ubiquitination.
Links
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Statistics
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PSSM-Id: 239078
Aligned: 19 rows
Threshold Bit Score: 54.2752
Created: 29-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:Zinc-binding sites [ion binding site]
Evidence:
  • Comment:6 conserved cysteines and 2 conserved histidines coordinate 2 zinc ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       #   #              #  #        #  #              #   #     
NP_064507   7 VSCDA-CLk--GNFR-GRRYKCLIC---YDYDLCASCYESGat-----ttRHTtDHPMQCI 55  human
CAB72283   96 VRCDG-CGn--NRMT-FYRYKCLHC---LDYDLCSDCKENGvs-----ngLHSlDHPLQCL 144 fruit fly
EAL33261    7 VVCRG-CSk--MGFT-GRCYRCLSC---PNFDICADCYDLDft-----teSHLfDHPVKCV 55  Drosophila pseudoobscura
EAL31707    7 ATCDG-CDlwgNGIT-GCRYKCLKC---ADFDLCKSCYDAKvv-----sgRHKsEHPMQCL 57  Drosophila pseudoobscura
AAF44864  117 IECKG-CGk--RSLT-FRCYRCLSC---QDFDICEECYDNDft-----tsTHPfDHPVVCV 165 fruit fly
AAS52713  263 MRCAGrCE---SDLTgRQYYRCIQC---DAFHLCVDCFHKGva-----ivEHVnAHGISCQ 312 Ashbya gossypii ATCC 10895
NP_872327 232 IPCNN-CK---QFPIeGKCYKCTEC---IEYHLCQECFDSY---------CHL-SHTFTFR 275 human
XP_466803 297 VGCDS-CGm--YPIR-GKRYKCKDCtelIGFDLCEECYNTKsklpgrfnqHHTpDHRMELD 353 Japanese rice
BAB02890  309 AGCDS-CGv--YPII-GDRYRCKDCkeeIGYDLCKDCYETPskvpgrfnqQHTpDHRLELA 365 thale cress
AAW27784  133 ISCKL-CE---KSNWsGERYTCLFC---SNIVLCKECFNTG---------YHN-EHPILCT 176 Schistosoma japonicum

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