1WIA


Conserved Protein Domain Family
Ubl_TMUB2
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cd17132: Ubl_TMUB2 
ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
TMUB2 is composed of an uncharacterized transmembrane domain and a ubiquitin-like (Ubl) domain-containing protein that shows high sequence similarity to TMUB1; the latter is highly expressed in the nervous system and is involved in the termination of liver regeneration.
Links
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Statistics
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PSSM-Id: 340652
Aligned: 7 rows
Threshold Bit Score: 142.274
Created: 23-Nov-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
key conservedkey conserved
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K27 (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering); may have other functions, for example for NEDD8 it is involved in the mechanism of protein neddylation
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                   #                                           
1WIA_A         7 GINVRLKFLNDTEELAVARPeDTVGTLKSKYFPGqESQMKLIYQGRLLQDpaRTLSSLNITNNCVIHCHRS 77  house mouse
XP_007899720 172 QIKVRLKFLNDTEEVARVKPeDTIGFLKSKYFPGqEQQMKLIYQGQLLQDqsRTLGSLNITDNCVIHCHIS 242 elephant shark
Q71RG4       173 LITVRLKFLNDTEELAVARPeDTVGALKSKYFPGqESQMKLIYQGRLLQDpaRTLRSLNITDNCVIHCHRS 243 human
XP_014341723 170 QIKVRLKFLNETEEIALVKPeDTIGFLKSKYFPGqEQQMKLIYQGQILQDqtRTLGSLNITDNCVIHCHFS 240 coelacanth
EMP33738     163 LIKVRLKFLNDTEEVAMVRPeDTVGVLKSKYFPGqENQMKFIYRGQLLQDqaRTLRSLNIMDNCVIHCHLS 233 green sea turtle
Q4V9Y1       164 LMTVRLKFLNETEEVAMVRPnDTIGMLKSKYFPGqEQQMKLIFQGQLLHDssQTLCSLHITDNCVIHCHRS 234 tropical clawed frog
NP_001005573 136 SITVRLKFLNDTEEIAVLRPqDTIGLLKSKYFSGrEHQIKLIYQGQLLQDpqRSLLSLNITHNSVLHCHIS 206 zebrafish

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