Conserved Protein Domain Family
TMEM37

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pfam15108: TMEM37 
Voltage-dependent calcium channel gamma-like subunit protein family
This family of transmembrane proteins, TMEM37, has a role in stabilising the calcium channel in an inactivated (closed) state. It is a subunit of the L-type calcium channels. This family of proteins are found in eukaryotes. Proteins in this family are approximately 210 amino acids in length.
Statistics
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PSSM-Id: 434465
Aligned: 9 rows
Threshold Bit Score: 248.495
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELV10284       1 AQRLLGPRRPHrRSFFESFIRTLIILCAALAVVLSSVSICDGYWLLAGDRVFGLWHFCTT-----------TNQSEIHCL 69 
XP_019653439   8 AQRLLAQRRPQ-RPFLESFIRALIIVCAALALVLSSISICDGHWLLAEDRLFGLWHFCTS-----------SNQTGTHCL 75 
Q6NUY2         9 GPVPRVKSSPL---FLDLFCRGLIILCTSVSVVLSSVAVCDGHWLLSGQHMFGLWYFCSVevpqgsvlgpqSFTASANCT 85  zebrafish
XP_006636427   8 AGSVHFYSKPK-PPFLEIFTRSLIILCTAFAIVLSSIAVCDGHWLLAEGKMFGLWHFCTL-----------EDKSLPNCT 75 
XP_005991126  10 GT--LYGRRPR-RPFFDAFIRSLIILCTAIAVVLSSISICDGHWLFVNNRVFGLWHFCNV-----------GNDGQRECT 75 
XP_001234272   8 AQRLLAHRRPQ-KAFFETFIRSLIILCVAIAVVLSSISVCDGRWLLARGELFGLWHFCAI-----------GNDSAPRCV 75 
Q3ZCJ1         8 AQRLLGQRGPH-RSFFESFTRALITLCTSLAVVLSSISICDGEWLLAGDHLFGLWRFCTA-----------SNQTELHCL 75  cattle
XP_002812459   8 AQRPLGQRQPH-RSFFESFIRTLIITCVALAVVLSSVSICDGHWLLAEDHLFGLWHFCTA-----------TNQSAPICF 75 
EGV99073      37 TQRLLGPKRPH-RSFFESFIRTLIIVCTALAVVLSSVSICDGHWLLVEDRLFGLWYFCTI-----------SNHSEPHCM 104
ELV10284      70 RDFSGTGVPGLPMVLGLARSMGALAVVAAIFGLELLMVSQVCEDIHSRRKWAMGSILLLVSFFLSSGGLLCFVILLRSHI 149
XP_019653439  76 RDLSRAQVPGLAVGMVLARSMGALAVVAAILGLELLMVSQVCEDLHSRSKWAVGSVVLLISFVLSSGGLLSFVILLWNHV 155
Q6NUY2        86 RRLEEAGVEGLDMGLAACRSVITLAVVSAIFGLELLVMSQASEGRDSSRRWTLGARLVLLAGVMAAGGVATFVLILGAFA 165 zebrafish
XP_006636427  76 TDLGEAGVDSLPVGLVLCRSVVSFSVVAAIFGLELLVMSQVCEDQDSRKRWSVGSALVLLSFTLSASGLLGFVALLWSYA 155
XP_005991126  76 TDLNMARVTGLQLWTAFSRSLASLAVVVAIFGLELLIISQVCEDAHSSRKWSLGSALVLASFALSFGGVVTFTLLLKDFV 155
XP_001234272  76 TDLRLARVEGLSVGMILIRSMVSSAVAVAIFGLELLMVSQVCEDASSRRKWSMGSVLILGSFLLSATGVLSFLILMKDHL 155
Q3ZCJ1        76 RDLSQTQVPWLASGLVVARIVATLAVVVAIFGLEFLIVSQVCEDSLAWRKWAMGSTLLLISFILSFGGLLSFLVLLRSQV 155 cattle
XP_002812459  76 RDLGQAHVPGLAVGMGLVRSVGALAVVAAIFGLEFLMVSQLCEDKHSRRKWVMGSILLLVSFILSSGGLLGFVILLRNQV 155
EGV99073     105 RDLSQAHMPGLAVGMGLARSVAALAVVAAIFGLELLMVSQVCEDVRSRRKWAIGSYLLLVAFILSSGGLLTFIILLKSQI 184
ELV10284     150 TFMGFTLTFWCEFTASFLFFLNAISGLHINSITH 183
XP_019653439 156 TLTGFTLMFWCEFTASFLFFLNAISGLHINSITQ 189
Q6NUY2       166 SLLGFTLTFWCQFTATFLFFLNGMAARHIQNIKP 199 zebrafish
XP_006636427 156 SLLGFSLTFWCQFTAAFLFFLNGMSGHHIHSMVL 189
XP_005991126 156 SFTGFTLTYWCEFIASFLFFLNGLSGQHINGIIV 189
XP_001234272 156 TFTGFTLTYWCEFIAAFLFFLNGISGLHINSITQ 189
Q3ZCJ1       156 TLLGLTLMFWSDFTASFLLFLNGISGLHINSITH 189 cattle
XP_002812459 156 TLIGFTLMFWCEFTASFLLFLNAISGLHINSITH 189
EGV99073     185 TLMGFTLMFWCEFTASFLFFLNATSGLHINSLTQ 218
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