Conserved Protein Domain Family
EcKinase

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pfam02958: EcKinase 
Ecdysteroid kinase
This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates.
Statistics
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PSSM-Id: 397213
Aligned: 51 rows
Threshold Bit Score: 233.7
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9VPY7        39 GLDGFMSALYTVTLDV---------VIAERKRT----EVVLVKFMK-GTEEFRESSNSYIQFSNEIFAYAEILPAYENVL 104 fruit fly
1_pfamImport   1 KGDGFIGELFRAYL-------------TEGDRR----EAYLCKIPP-LNEARRQQFETMEIFEREVLMYNKLLPLMFAYQ 62 
Q7Q8B7        52 ECDGYVSFVFKAII-------------NGDDRE----FTLWCKVPPnGDER------SLELFKRECFFYRETLHGFYEFQ 108 Anopheles gambi...
XP_003436049  63 EGDNYMSIIKRVKAHCkak----svDGRNHVFT----ISLIFKRQI-TNPNRRRLFRCDAAFENEITAYASIVPVLQRIS 133
Q9VSS3        64 SGDNYMSVVKRVTISQagkdqdpelAGSEI-------VTVIVKRQI-ASLSRRQLYRCEEAFSNEINAYRHLAPLLAAHS 135 fruit fly
Q7PQT3         1 RGDNYTAALFRIALKGhtl---pdgGTKKLKWE----KSIICKRLP-DCKIKREAFKSEALFRNEVVFYNTIMPEYVAFQ 72  Anopheles gambi...
Q9VEB7        55 RGDNYTAALYRIKLTG---------KRRSLKWE----QNVICKVMP-ESVVAREAYKSDKLFRNEVQFYNTIMPELLKFQ 120 fruit fly
Q7QBD5        43 KGDAYLSELYRIQLTG---------EPAEPGRDeplvVNVVVKTIP-KNVGRRNTFRSADFFRNEANFYNVVLKELYRFQ 112 Anopheles gambi...
Q9VYW8        52 KGDNYLGVVWRLQ--------------AASDSK----RSLVVKLPP-QNRVRRKQFFARPCFLRETAAYEVFLPLTALIQ 112 fruit fly
Q9VW98        33 VGENAYGQVLRVSWPTiv-----------------daATVVVKMAP-RNEARRSHMHVVDYYAREVFMYQKVFPVFRALS 94  fruit fly
Q9VPY7       105 RTShles---------evvkNWVPCCYFARfg-hvEGLGngrESVLALKHLKGDGYQLGPR-LTLRRDQLEAMVGLVGPF 173 fruit fly
1_pfamImport  63 EAKgvsr---------edgfFSIPKCYHAH-----YDGQs-aEAIIVMEDLRLNHYSMFNKdKPVDYEHARLTMEQLGRY 127
Q7Q8B7       109 AEKglsee-------sgdgfYATPKCYLAHcntdaPEPE----ALIMLEYNEAFEKWDWDKlEPINVEHTRLVMEQLGRL 177 Anopheles gambi...
XP_003436049 134 PYD-----------------LPYPKCVTAG-----SDEH---GDRIVLEDLTTSGYAMLDRrVGLSYEHCIAVMKELAKL 188
Q9VSS3       136 RHQ------------------LFPVCHIAEsqdrrDAEGg--EPIIVLQDLKAMGFRMKDRlAGLELSDCLLVMKKLAQL 195 fruit fly
Q7PQT3        73 RRQvetvgagtdvpaserlfQAIPHCYLAR------------DDLIVLEDLRVRSFTMPDRqAGLGPQQLEAVLAELARF 140 Anopheles gambi...
Q9VEB7       121 ASKtnqd---------tpvfNAIPKCYSAR------------HDLLIMEDLRERGFQMSDRhKGLSLEETQSVLLQVAQL 179 fruit fly
Q7QBD5       113 -DArkpa----------npfKDINPCYVAY-----TDGV---NDFVAMEDLGQYGYKTASRaEGVGLEECKRCMRSLGRF 173 Anopheles gambi...
Q9VYW8       113 DKWkiig---------ddrfRQHALCFGTR-----QDEP---NECIVLEDLSCAGFSLHNRfLDLSVEHVRRVMLTYAKL 175 fruit fly
Q9VW98        95 PDRnt--------------fTVAPALQAND-----LKAP---DEFLIFEDLSESGFRPNSRcIMPTYDIVVCSLKALAEL 152 fruit fly
Q9VPY7       174 HALGYATKILQPNVHARLR--AGVVDMPFVSSSGKGIFDVLYRVAFDRFYEFYDRQKEQLLQGAdpgfgAAIERLRE--K 249 fruit fly
1_pfamImport 128 HAVSLAMKHDRPEQFEQFK----MLDSMKESMSPEHPFIVMLQKTTRDAMETL---EPHEARER-----NKMQKLLN--G 193
Q7Q8B7       178 HALSFAMKEQRPELFEQYK----------RAGQPDSALITLMKESFDRALITMRTRFESEQ--------ERIVAVKD--A 237 Anopheles gambi...
XP_003436049 189 HAVSLAMKHAHPHEYADVC--SKIREIVYCPEA-AEFYTHSLESSLRGALDSLRYSNGEQGELDgp--iRAVEGLTG--R 261
Q9VSS3       196 HAASLAAQELESSSFAFHA--DHLQEIVYCDEA-TDFYATILDTSVQQALESLGDANADDCLTTp---iRLLEELRT--N 267 fruit fly
Q7PQT3       141 HAVSLAYQRrHPAEFRQLT---GALEEGIFSQANEEWYRRYYDVLTRNAIQMVRQTVPEKRDHL-----AKLERFLG--N 210 Anopheles gambi...
Q9VEB7       180 HGLSLAYKFEKPLEFSNLC---SMISEGIFCTANTSWYRNYYERLTKNAIQMVSEVLPPDSKYV-----LAMNKFAEssS 251 fruit fly
Q7QBD5       174 HALSLAMKEQEPDRFHEIA--QQHVEETYYSARLKSWYNNFLQVQIDIARDAMAREYPGTELER------TMEKFFDc-D 244 Anopheles gambi...
Q9VYW8       176 HAISLAGKRQLPEKMQQLQqlVDIFEQRRDDHALGVYFENLKESALSALLAPADDAYRVR---------LEAYFARG--S 244 fruit fly
Q9VW98       153 HACSFILQQTDPLQFKQLV--EFVEKDNLFTSDIEEVTIEFGKAQLRKARIILKES----DGDQvaavqEVLQLCEN--Q 224 fruit fly
Q9VPY7       250 YFKQPTLLLerirtssfaedQPDSHFATFLHGDYNRNNVLFHYGAED--KVDAIKAIDFQELRFSTTAIDLSFFMYMNTP 327 fruit fly
1_pfamImport 194 MLADVDRYAn---------fELAEPYAVLGHGDCWINNMMYRYK-NG--TPEHIVLLDWQVARYCSPILDLAYFIFCCTD 261
Q7Q8B7       238 VFESLKTCCd---------pTTAEPYCVVTHGDCWINNLIYSHNENN--VATGVILTDWQSSRYASPILDLCYFFFISAG 306 Anopheles gambi...
XP_003436049 262 LYRIMSALVc---------dGMDEGWRVICHGDTWVNNLMFSADRQH------VRLIDLQTMRCTTPVLDILHLLYTSTE 326
Q9VSS3       268 LFENLKHEIn---------aTAAAPNSVICHGDLWVNNIMFRS------EPEEVIFFDLQAMRKSSPIFDILHFIYTSTR 332 fruit fly
Q7PQT3       211 CFGHLVELV-----------NRTSELSVICHGDCWTNNILFRYDEAG--AIAETCLVDFQLIRHGSLALDLAYLIYCCTD 277 Anopheles gambi...
Q9VEB7       252 FFGRMVKLA-----------STESPLSAICHGDCWVNNFLYHYDPEDphRVLEVALLDFQLIRYSSIALDIANLLYCCTT 320 fruit fly
Q7QBD5       245 LYDHMVYLT-----------HTRNQNSVINHGDCWMPNFLF-HDSTP-----AMRMIDFQLARYCSPALDIAFFVYSCTS 307 Anopheles gambi...
Q9VYW8       245 YFELLLPLVs---------gFNCEPFAVICHGDCWNNNILYKSTERG--ELEDVRLIDWQLMRYASPVTDLAYFLFTCTS 313 fruit fly
Q9VW98       225 LKSLALYCVd---------gKAQAPHAVICHGDFWNNNILYRHEPNSd-QPVEAKLIDFQMSRYAPPVLDIVHYLFACTE 294 fruit fly
Q9VPY7       328 SEGRKEIYADLLRKYHRSMIEmLELVLRR 356 fruit fly
1_pfamImport 262 EEFRRRHYDEMMSIYYNSLAT-LLEKLGH 289
Q7Q8B7       307 EQFRRDNMDSLLHHYHGALAD-FLAKLGG 334 Anopheles gambiae str. PEST
XP_003436049 327 HSMRRQYVPELLLQYRQSL----LAALGE 351
Q9VSS3       333 RPLRDVHTDTLLAAYSQALSE-ELRHQLE 360 fruit fly
Q7PQT3       278 GALRKKSLQHWLQTYHQQLVR-SLRLLLG 305 Anopheles gambiae str. PEST
Q9VEB7       321 KEMRDAQLQTLLKIYTEELFR-WLQMLCT 348 fruit fly
Q7QBD5       308 QALRDAHYEDLLGAYHGGLAE-MLRDLGS 335 Anopheles gambiae str. PEST
Q9VYW8       314 RRFRQRHLENMLEDYYEELGL-QLIRLGE 341 fruit fly
Q9VW98       295 KRLRDEHFPDFMDAYYNTMDQ-KLKSCNL 322 fruit fly
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