6BJC


Conserved Protein Domain Family
TPX2_importin
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pfam12214: TPX2_importin 
Cell cycle regulated microtubule associated protein
This domain is found in eukaryotes. This domain is typically between 127 to 182 amino acids in length. This domain is found associated with pfam06886. This domain is found in the protein TPX2 (a.k.a p100) which is involved in cell cycling. It is only expressed between the start of the S phase and completion of cytokinesis. The microtubule-associated protein TPX2 has been reported to be crucial for mitotic spindle formation. This domain is close to the C terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localization signal in this domain.
Links
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Statistics
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PSSM-Id: 463495
Aligned: 32 rows
Threshold Bit Score: 122.028
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6BJC_P       367 PQTPVLQTKHRARAVTCKSTAELEAEeLEK-----LQqyKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRI 441
Q4V3B0       249 PQEPDFATSHRANRIRHKNDAKLEQD-STS-----VY--RFKARPLNRKIFEAPSLPIRKNSTPKLPEFQEFRLKTSERA 320 thale cress
NP_001078430 249 PQEPDFATSQRAHRIRHKNDAKLEQE-QPA-----VY--RFKARPFNRKIFDAPSLPIRKKSTPKLPEFQEFHLKTSERA 320
XP_009136255 222 PHGADFVTSQRALRIRQKNDAKLEQD-STA-----VY--KFKARPLNRKIFDAPSLPIRKKSTPKLTEFQEFHLKTSERA 293
EEF51033     248 PREPDLETAHRAHRMRPKNNTEVEHV-TVA-----AQ--RFKARPLNRKILEAPSLPLPKKSTPKLPEFQEFHLKTLERA 319
1_pfamImport   6 PREPELETARRAFSFRAQRQRLVDAKcLVEgmpqfTS--TFKAHPLNRKILEAPSLPLPQKSTPRLPKFKEFNFRTHSRA 83 
ERN19493     318 PREPELETAQRARRIMIKKNSDAGEGmLLM-----AP--KFKARPLNRKIFEAPSVPLPQKSIPRVPEFREFHLKTTERA 390
KRH04063      91 PREPDLRTARRAHRIRPKNVGEAEHV-TVA-----AP--KFKARPLNRKILEAPSMLPPKRSTPRLPEFQEFHLKTFERA 162
KRH77444     251 PREPDLETAHRAQRIRPKIAAEAEVV-TVA-----AP--IFRARPLNRKILNAPSLPLPKRSTPRLPEFQEFHLKTQERA 322
CBI34799     258 PREPNLETAYRTQRMRSKHHTEVDQV-ALN-----VH--RFKARPLNRKILEAPSLPLPKKSTPRLPEFQEFHLKTSERA 329

6BJC_P       442 QERESKKKTE----------------------------------------------De-------HFEFHSRPCPTKILE 468
Q4V3B0       321 MQHSSAVSTSsyqgnnnhkeadkpnrtf----------pdgvnreprrqraidipkDdv-----rKDLFKARPLNKKILS 385 thale cress
NP_001078430 321 MQHSSAVTTRshaykesdksiitdmld-------------gdnresrrpsgmdiskHdvs---egSHVFKARPLNKKILS 384
XP_009136255 294 MQHSSQVTKRsnqwnhaykgpdksnitdv---------fdgvsmesrrpsgmdiskHdvs---egKHVFKARPLNKKFPD 361
EEF51033     320 MQHAFVVSSSslqhndseqgldksttvsv---------aeigkresrrpstvdtkkQdgc---saPHVFKARPLNKKIFT 387
1_pfamImport  84 LLHSTTSSTLvgsinldfcslmksctvhiliqy-qyigslrpnclinlkmnvehecKrdaevkdiSTKFRPQALNQKILA 162
ERN19493     391 IQHAAAAPSLpshvdsnnvankhkhassnqvgtidlkmschqaphlekhkvvdepkQeqr---erIATFKARPLNPKILS 467
KRH04063     163 MQHTSAMSSsfhyddsdkgwdkhtsvsa----------lenrikdlrrpaaaaaptNdgl---gfTHIFKAQPLNKKILP 229
KRH77444     323 MQHTSATSTSslhcndsdkdldkhravsa---------qenrirdlrrpsamgapkHdgl---dfAHSFKARPLNKKILS 390
CBI34799     330 RQHTTGSSSslhcndpdkglqkpstnsv----------pengnkdlrrpnttdapkQdac---etVRTFKARPLNKKIFS 396

6BJC_P       469 --DVVGVPEKKVLPITVPKSPAF 489
Q4V3B0       386 sgREIGMFTKSKRETTAPLGFSF 408 thale cress
NP_001078430 385 srGDMGIFKNSKRETTVPLEFSF 407
XP_009136255 362 --------KDETDSEMATQEFNF 376
EEF51033     388 skGDIGVFRNSKRETTVPTEFNF 410
1_pfamImport 163 skGDIGVFRSTKRDTTIPKEFNF 185
ERN19493     468 skGDIGMFKNCKREATKPTEFSF 490
KRH04063     230 skGNGGVFHNSKQETTVPMEFDL 252
KRH77444     391 skGDIGVFRNRKQETTVPMEFNF 413
CBI34799     397 skGDIGVFRNSKRETTVPLEFNF 419
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