1BZC,1L8K,1EEO


Conserved Protein Domain Family
PTPc-N1_2
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cd14545: PTPc-N1_2 
catalytic domain of tyrosine-protein phosphatase non-receptor type 1 and type 2
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) type 2 (PTPN2) belong to the family of classical tyrosine-specific protein tyrosine phosphatases, (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN1 (or PTP-1B) is the first PTP to be purified and characterized and is the prototypical intracellular PTP found in a wide variety of human tissues. It dephosphorylates and regulates the activity of a number of receptor tyrosine kinases, including the insulin receptor, the EGF receptor, and the PDGF receptor. PTPN2 (or TCPTP), a tumor suppressor, dephosphorylates and inactivates EGFRs, Src family kinases, Janus-activated kinases (JAKs)-1 and -3, and signal transducer and activators of transcription (STATs)-1, -3 and -5, in a cell type and context-dependent manner.
Links
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Statistics
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PSSM-Id: 350393
Aligned: 10 rows
Threshold Bit Score: 389.444
Created: 28-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 13 residue positions
Conserved feature residue pattern:x x x x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the binding of human PTBN1/PTP-1B to peptide substrates and peptide mimetic
  • Structure:1EEO: Human PTPN1/PTP-1B binds Ac-ELEFpYMDYE-NH(2) consensus peptide; contacts at 4A
  • Structure:1BZC: Human PTP-1B binds peptide mimetic; contacts at 4A
  • Citation:PMID 9922143
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ####                                                                       
1BZC_A        41 KNRNRYRDVSpfdhsri---klhqednDYINASLIKMeeaqrSYILTQGPlpntcgHFWEMVWEQksRGVVMLNRVmekg 117 human
1L8K_A        43 RNRNRYRDVSpydhsrv---klqnaenDYINASLVDIeeaqrSYILTQGPlpntccHFWLMVWQQktKAVVMLNRIveke 119 human
1EEO_A        41 KNRNRYRDVSpfdhsri---klhqednDYINASLIKMeeaqrSYILTQGPlpntcgHFWEMVWEQksRGVVMLNRVmekg 117 human
ADD38803      44 LNRYGDVHPYdhsrvvl---hikngrsDYINASLVRNerakrRYILAQGPldltigHFWSMVWHEnsKAILMLNKLmekg 120 salmon louse
XP_002129090  48 RNRYRDVSPYdhsrvk-----lvggqnDYINGNLVEVesigrSYILAQGPlpntsgHMWQMIWEQnsKAVIMLNKIiekg 122 Ciona intestinalis
XP_787465     46 LNRYRDIHPYnhtrir-----lergdvRYINASLIEAplakrKYILTQGPltrtvcHFWQMVWEQdsRAIIMLNNFvenh 120 purple urchin
XP_001633695   9 LNRYRDVLPYdhsriil---estqngtDYINANLVEFpelgkRYILAQGPlphtadHFWQMVWENnsKAVIMLNKVmekn 85  starlet sea ane...
XP_002593971  41 KFRNRYRDVSpydhsrv---qlqdgdnDYINASLVEAteanrQYILAQGPlpstigHFWEMVWEQrtKAVVMLNRViekg 117 Florida lancelet
EFO22339      50 ADRNRYRNVLaydtsrvvlkrensersDYINASRLVVptakrNYILTQGPlsttsnDFWQMVWEQnsTLIIMLNKLvekg 129 Loa loa
347081        63 LNRYRDVNPYdhsriv-----lkrgsvDYINANLVQLeraerQYILTQGPlvdtvgHFWLMVWEQksRAVLMLNKLmekk 137 fruit fly

Feature 1                                                                                       #
1BZC_A       118 sLKCAQYWPqkeekem----ifedtnLKLTLISEDIKsyYTVRQLELEnltt-----------qetREILHFHYTTWPDF 182 human
1L8K_A       120 sVKCAQYWPtddqem-----lfketgFSVKLLSEDVKsyYTVHLLQLEnins-----------getRTISHFHYTTWPDF 183 human
1EEO_A       118 sLKCAQYWPqkeekem----ifedtnLKLTLISEDIKsyYTVRQLELEnltt-----------qetREILHFHYTTWPDF 182 human
ADD38803     121 iKKCEQYWPphpgdsf----ickdvnIKVENLQSESRndYILTNLRITnlav-----------neeRMVLHFQYIAWPDF 185 salmon louse
XP_002129090 123 tTKCDQYWPinpiqpl----cfledgYEVALLNEKDNmnYIVRELELRklks----------seppRIIYQFHYIAWPDF 188 Ciona intestinalis
XP_787465    121 qQKCADYFPrgqdngntdellcedtlLKVTYLRQERHhyYIVRTLLLEdlvt-----------qqtKEILHFHYTRWSDF 189 purple urchin
XP_001633695  86 qIKCFQYWPcgeryahv--ncleldsFQIKYITENRSeeFTVRILELEnkkt-----------ketRVVYHYHYLTWPDF 152 starlet sea ane...
XP_002593971 118 tIKCAQYWPqgevngysdeldleetgYKVTLLEEDVRpyFTIRTYLLHrlkt-----------nesRKVFHFHYTRWPDF 186 Florida lancelet
EFO22339     130 lPKCHDYFPslsspa------refdsFNVVLKDEQDFddYVIRDLELLrktgdillekdepdgpfsRMVKHFHFTSWPDF 203 Loa loa
347081       138 qIKCHLYWPnemgadka--lklphvkLTVELVRLETYqnFVRRWFKLTdlet-----------qqsREVMQFHYTTWPDF 204 fruit fly

Feature 1                                        #######                                        #
1BZC_A       183 GVPesPASFLNFLFKVRESgslspehgPVVVHCSAGIGRSGTFCLADTCLLLMdkrkdPSSVDIKKVLLDMRKFRMGLIQ 262 human
1L8K_A       184 GVPesPASFLNFLFKVRESgslnpdhgPAVIHCSAGIGRSGTFSLVDTCLVLMe---kGDDINIKQVLLNMRKYRMGLIQ 260 human
1EEO_A       183 GVPesPASFLNFLFKVRESgslspehgPVVVHSSAGIGRSGTFCLADTCLLLMdkrkdPSSVDIKKVLLEMRKFRMGLIQ 262 human
ADD38803     186 GVPrcPDTFLNFLQAVRQTgsleedvgPPVVHCSAGIGRSGTFCLVDTSLVLIak-egPSSVILKDILLDLRTYRMGLIQ 264 salmon louse
XP_002129090 189 GVPesPTAFLDFLACVREHgvldsnvgPPVIHCSAGIGRSGTFALVDTCLVYLk---mGLPFDVREILLEMRKYRMGLIQ 265 Ciona intestinalis
XP_787465    190 SVPqsPAAFLQFLHHVRRSgslvdnvgPPVIHCSAGVGRSGTLCLVDTCLVQIekkgnTSGLDVRKQLLDMRRYRHGLIQ 269 purple urchin
XP_001633695 153 GVPkaPGYFLSFLFECRNAgvlssdvgPAVIHCSAGIGRSGTFVMIDSILAEVst-gnLNAVDLGERLLAARQYRVGLIQ 231 starlet sea ane...
XP_002593971 187 GVPesPAAFLHFLQEVRNSgslesdvgPPVVHCSAGIGRSGVFCLVDTCLVLLdktrdLNSLNMRQLLLEMRQYRMGLIQ 266 Florida lancelet
EFO22339     204 GVPhsTAVFIGFLQKVRDTglls-gkePTVVHCSAGIGRSGTFVVADSVLSMVeq--nVKKIDVTNLVIEMRRSRMGLIQ 280 Loa loa
347081       205 GIPssPNAFLKFLQQVRDSgclsrdvgPAVVHCSAGIGRSGTFCLVDCCLVLId---kYGECNVSKVLCELRTYRMGLIQ 281 fruit fly

Feature 1                  
1BZC_A       263 TAEQLRFSYL 272 human
1L8K_A       261 TPDQLRFSYM 270 human
1EEO_A       263 TADQLRFSYL 272 human
ADD38803     265 TWEQLKFSYL 274 salmon louse
XP_002129090 266 TPQQLRFSYL 275 Ciona intestinalis
XP_787465    270 TWQQLRFSYC 279 purple urchin
XP_001633695 232 TPDQLRFTSI 241 starlet sea anemone
XP_002593971 267 TPDQLRFSYL 276 Florida lancelet
EFO22339     281 TPQQLQFCWK 290 Loa loa
347081       282 TADQLDFSYQ 291 fruit fly

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