Conserved Protein Domain Family
Smg4_UPF3

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pfam03467: Smg4_UPF3 
Smg-4/UPF3 family
This family contains proteins that are involved in nonsense mediated mRNA decay. A process that is triggered by premature stop codons in mRNA. The family includes Smg-4 and UPF3.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

pfam03467 is classified as a model that may span more than one domain.
pfam03467 is the only member of the superfamily cl47815
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KIS71801     123 QFKSKVVIRRLPPNLPAHVFWKAVSpwirdsadcqaltttaqtssapaqpgaetseahtsdsrsaatssastSPTpTVDY 202
A0CWM3        11 pQSFKVHIRRLPPLLREEEFYATIQ-----------------------------------------------EYLnDIVM 43  Paramecium tetr...
XP_011271494  64 DAGFKVVVRLLPPNLKAEEFWSKVEd---------------------------------------------yVTAqNILD 98 
Q756Q0       115 DVGHKLVVRLLPPNLTEDEFYRTLCphlp----------------------------------------seqFFEkTTRD 154 Eremothecium go...
CCE65625      63 VSGFKLVLQSLPPALTETEFWDAVKsvvn----------------------------------------dtnEYQiNLNS 102
XP_003681278  62 DVGVKLVLRLLPPDLSQDQFLETIKpev------------------------------------------geFSDcGVLE 99 
P48412        83 NEGFKLVIRLLPPNLTADEFFAILRdnnndd-----------------------------------gdkqdiQGKlKYSD 127 Saccharomyces c...
CCK72464     111 SEGFRVVMRLLPPNLTFEELCTTLKteit----------------------------------------sdfVSVyRISD 150
CAR22151      62 SAQYKLVLRQLPPNLMEEQFFDTVSaav-----------------------------------------gsdFLQqHVED 100
XP_001014619   6 SEVFRVDVRKLPPNLSKEEFQQAIR-----------------------------------------------DYQsNIIY 38  Tetrahymena the...
KIS71801     203 KQFVAGKlktDTNKQNKHARAYVRFLDAQMLVQFYKAFDGHIFRD-SRGNESIAIVEFAPYQKVvvsTPrtgtrggprAA 281
A0CWM3        44 KYYVKGK---LKEQEKIDSRCYLFFNCDAAMSRFIQGYKK-VFCD-EKGIYYQPDIGKALLQNQqdhLR----------N 108 Paramecium tetr...
XP_011271494  99 KYYVQGKysnKPFKLPTYSRAYIQFEDPQIVDQFVAKYKEVTFEDdKE--SMIPTFAMALFSKMpenEKs-------pSK 169
Q756Q0       155 RYYVPGHysrKPFKLPTYSRCYLIFYDLAALQTVGRILQNMTFVD-DHDNATVPKLFLSPYVKKmrnLGghm----qiQD 229 Eremothecium go...
CCE65625     103 FYFVQGKlsdKPFHDPVYSRSYIMFKDMENLRKFALKIQDVTFTD-ANNDSSVASIKISPYNRSynsALekk----kpAA 177
XP_003681278 100 WYYVRGHypqKLSTRPVYSRCYLIFESTESLAEFTKKVQPIKFVD-DKDNATNVVTRVSTYVKRfvpNTvd------pSP 172
P48412       128 WCFFEGHyssKVFKNSTYSRCNFLFDNLSDLEKCANFIKTCKFID-NKDNITIPDMKLSPYVKKftqTS----------K 196 Saccharomyces c...
CCK72464     151 IYYVQGHysvKAFNEPIFSRCYFHFDDMENLKAFVMKLQGIMLVD-DRDNAVKPTIKLTPYAKKlsdTNpng----fgKS 225
CAR22151     101 RYFFKGHfsrKPFKLPTYSRAYMTFNEAEKLQFFAKSVSAVTFVD-DTNNSMVPTVTLSPYLKKlrtEEsk-----glRK 174
XP_001014619  39 QYYVPGQ---IKEKEIVFSRAHLNFNTQENGLNFLNNFKQ-KFADkQNNTVYEPVLRKSLYQI----------------N 98  Tetrahymena the...
KIS71801     282 KLDAQQGTIDKDAD----YQCFLERLSKADDQ-VQRSeGELLASLLDSKGKEke--------------------tEARRL 336
A0CWM3       109 KPKPLEGEYQKTEL----YKRFLKFLEEEQLQqQEMEnAQTQQLKEEPINPEd----------------------KPKKF 162 Paramecium tetr...
XP_011271494 170 KPDSKPKHTLQDLLs---YKNFLKFYNGEIERpQSFLiSEKNDKRAEKRA-------------------------AKKAE 221
Q756Q0       230 QKLKLEGTLDKDPI----FQIFTKSLQ------------------LLEENKGeyqykdlhilnplekelkkrrevDGSIK 287 Eremothecium go...
CCE65625     178 NKKVLEGTIKDDPL----FKAFVQSMK-------------------IMAESDqymyseinlfkplkkeldkqkqvNEAIL 234
XP_003681278 173 VSAALEGTITEDPL----FLTFMKSLK------------------ILEEKKSdysfadvsilkplekevakqkavESEIQ 230
P48412       197 KDAALVGTIEEDEI----FKTFMNSMK-------------------QLNENDeysfqdfsvlkslekefsksielENKIA 253 Saccharomyces c...
CCK72464     226 KTFVLEGSLEETKL----FKNFMKSLKy----------IEKTQEAGDEGSLFnlldgsisllkplekelakkkkaEAAVK 291
CAR22151     175 TKDLIEGTIEQDRT----FQTFLKSLD------------------LLENHKQeyqyadlsvimplekalrrkleeEARVK 232
XP_001014619  99 PQNKDQSSIDSDYKagymYSQFVNYQEQQSKLnEQKVdISQIERKANEDTEE-----------------------KVKKF 155 Tetrahymena the...
KIS71801     337 AGKVTPLLL------HLREQKM 352
A0CWM3       163 EKVKTHIIM------ELEKEYQ 178 Paramecium tetraurelia
XP_011271494 222 KKAEKKVEK--------KNEKG 235
Q756Q0       288 KQVHDAMIElageiesedkkkk 309 Eremothecium gossypii
CCE65625     235 KQTEKALVEla---gAVESEKK 253
XP_003681278 231 RKTENALIAlt-----gDSGKK 247
P48412       254 ERTERVLTElvgtgdKVKNKNK 275 Saccharomyces cerevisiae S288C
CCK72464     292 RKTENALTEla---gSIAGNNK 310
CAR22151     233 AQGEKAMIAla--------gQV 246
XP_001014619 156 EKVQTPIIA------SIEQKKK 171 Tetrahymena thermophila SB210
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