3TJ3


Conserved Protein Domain Family
NUP50

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pfam08911: NUP50 
NUP50 (Nucleoporin 50 kDa)
Nucleoporin 50 kDa (NUP50) acts as a cofactor for the importin-alpha:importin-beta heterodimer, which in turn allows for transportation of many nuclear-targeted proteins through nuclear pore complexes. The C terminus of NUP50 binds importin-beta through RAN-GTP, the N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta then binds cargo and can stimulate nuclear import. The N-terminal domain of NUP50 is also able to actively displace nuclear localization signals from importin-alpha.
Statistics
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PSSM-Id: 462629
Aligned: 76 rows
Threshold Bit Score: 44.6313
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3TJ3_C          7 AKRNAEKELTDRNWDq----------EDEa--EEVGtFSM-ASEEVLKNRAIKKA---KRRNVGfesd----------tg 60  
XP_002551211    2 AKRVADEQITKDGFEg----------SSDgddAPQGpVQ--ASNDVLSKRKILKP---RGRLGTqpsgssgfngfsnvqm 66  
XP_007872708    2 SKREAEKQITKNDSIfsg-----nteQ------EVVdLAKqASKEVLLKRKIAVPqslKKRYSeqi-------------s 57  
XP_001385122    2 SKRGATDQITKDNF------------NERdddDEPQvFK--ASAEVMAKRKIIQP---KRRNIAsassassasstpsvpv 64  
EKG18214        2 SKRGATQQLSKEGTFfgd------gsNDLsgdDKPRk----ATAAQLANRKLKPL---KGRPRVagsttaqs--fppasq 66  
EMC98677        2 SKRLAESQGGEERYGksneggmtgsqDRApq---------aATAAQLARRKIIQA---RGRVSArgsraps----patgp 65  
CBJ27957       10 VKRTAEHQINKDEdp---------egDGVgqeVEAGtFQR-APAEVLKTRKIVKV---RSRSPAeqppa---------aa 67  
VDC64862       12 KKRGALKQLSRENPDd---------dEDVsadFESGtFKK-ASDEVLASRRIVRI---KRKEPSaapp-----------a 67  
Q9C829         12 KKRGALKQLSRDNPGld--------dDDDsaeLESGtFKK-ASDEVLASRRIVRV---KRKEPSaap------------v 67   thale cress
XP_002885120   12 KKRAALKELSRDNPGld--------dEEDtsaLESGtFKT-ASEEVLASRRIIRV---KRRDPSaaaa----------pa 69  
3TJ3_C         61 gaFKGFKGLVVP 72  
XP_002551211   67 pqSSSFSFGNGN 78  
XP_007872708   58 thSSPFANLQEP 69  
XP_001385122   65 sgKPAFAGLNGS 76  
EKG18214       67 psSNAFTGFAPT 78  
EMC98677       66 qqSNPFQTFQAP 77  
CBJ27957       68 asANPFASLGSA 79  
VDC64862       68 atTNPFAGIQLL 79  
Q9C829         68 aaSNPFAGIQLV 79   thale cress
XP_002885120   70 ptSNPFAGIRLV 81  
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