Conserved Protein Domain Family
AP-5_subunit_s1

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pfam15001: AP-5_subunit_s1 
AP-5 complex subunit sigma-1
This family of proteins are subunits of the adaptor protein complex AP-5.
Statistics
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PSSM-Id: 434380
Aligned: 13 rows
Threshold Bit Score: 213.363
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006005779   1 MVHGFLIHSLglg--ssGDSGLSRMLYSRMFN----SEp-kDPVLGADEQDLEEERLLRK--EQLAAVAR---QVKSSCI 68 
XP_016283704   1 MVHAFLIHTLsgsgqatGDATFCRVLYSQVFG----SE---RLPDEPGPRGPERDRLLRK--EQLLAVAR---QAETACK 68 
XP_003227913  34 MVHAFIVHTLrswgrsgDEAPPCRVLYSRVFS----PE----RPEGGGGRDPEKERLAQK--ERILAVAR---QVDSVCK 100
XP_003447889   1 MVRCFLIHTVcpv--saLSAGESRVLYSRVFG----PDd-gVLSERHRELSPEERRLLQK--EKVAAVAR---QVRSAVS 68 
XP_007237315   1 MVVCFLIHTVgav--gaLSPCESRVLYSRVFG----VEe--EDEELSGELEPEKRRLARK--ERLGVVAR---QVRSAVC 67 
NP_001292497   1 MVLCFLIHTVcpv--saLSAGESRILYSRLFG----AE-----SGDDRDFTPEQKRLMQK--EKLQVVAR---QVRSAVC 64 
XP_002416012   1 MVLAFLILSV--------SEKASGVIHSTAYSlnraGTshsDESNTVRNEPDELEEDFQR--GPSEMNEE---HKAQSDL 67 
CAQ39486       1 MVYGIIIHS---------SERHEKYYFSYYYD----AEkskVDVEEEENDCIRQQTIIKRvlEEITYYENe--KMKTDNT 65 
XP_004991672   1 MVMCLCVLDA-------RPSVEQPVAFSAFYG-------------MDKTLARQEYRNPKD--QQEAFLQHtikRVRDDAA 58 
EEN44006       1 MVRSVIIQTV--------TPGPCRVLYAQMYG---------CAGDQTGSLAQTAARGRQK--EQVATVAR---QVQSECS 58 
XP_003730604   1 MVYAFIIHTL--------PPDTCRVLFSCTFGl---EDagvDDHRIENEGDVTEMRTLRK--EQMALVAR---QVQSEFS 64 
XP_011438995   1 MVYAFVIHTL--------LPGPCRVLYHNVYG---------QDATYSDEVNDAEHKNRRR--NHIQLIAN---EVHSEYQ 58 
XP_006629156   1 MVHSFLIHTLcpv--gaLSCTESRVLYSRVFG----ADltqTGPAGDREQESEARRLLQK--EQLAVVAR---QVRSVCA 69  spotted gar
XP_006005779  69 LSW-QAAGKT-LHEFGLPPSDEPSVLQDA------EFGVFRLPLGDPFSE---TKIVVWLGIWFLSFTLICDPHENLMLA 137
XP_016283704  69 LLQ-QASGRP-PTDLLPQSSDEPIPLQDA------PSGVFRLRPGDPFQE---AKVVVWLRLLSLGCALVCEPHENLLLA 137
XP_003227913 101 LHL-QAAGRPtWEPLAPAP-EDPSPLQDA------PSGAFRLPPGDPFPAaegERAVLWLGVHSVAFALVCGPQENPLLA 172
XP_003447889  69 LSR-EASGRLiVE---TMPGEENLALQDA------DCGVVRLRAGDPFSE---ETSALWLGVQSLGFTLVCEPHENLLLA 135
XP_007237315  68 LSR-EASGSVcVE---AVLGEEAVALGEA------ECGVLSLGRGEPFAG---PSVALWLGVQAMAFTMVCQPHENLLLA 134
NP_001292497  65 LSR-EASGRLcVE---SVLGEEAVALGEA------DSGVFSLGSAELFPD---RSAVLWLGVQALAFTLICRPHENLLLA 131
XP_002416012  68 FKR---VHQHvVEDMKSALHHTSIAGAEAslhpieKKGAFFLNDTD--SP---ESIVVWHSFGDCCFVLMCDSDENVSLG 139
CAQ39486      66 AKKhREKYFDlLDAFLSKNNNDEGKIN--------GEGFFRIINPSLFKN---RINVLWKVVNKICYTLVFYAHENIHLA 134
XP_004991672  59 FQRtVERGAPpAP---NADPDEVAVSAQP------LEGGFRMEPGRAVDR---PKFVLWYQHGSLIVFTVAELSENIVLL 126
EEN44006      59 FQQhCAAADPvGEEVRRHLSQEGAVVP--------QTGIFQMPPGEPFGT---KVFTVWQTAANCGLALVCENHENRQQA 127
XP_003730604  65 FQK-AVSERVtYSDGLSSGQED--WMRDA------ELGMFRLAAGDPFKT---EKIAVWLGAGKTGFILVCETHENRLQV 132
XP_011438995  59 FRR-AVQSRAvEDDIQRMGNDD--TLPDF------EFGCIRLPEGNPFTV---ERIALWLGAGNSGFTLVCEKSENRLLA 126
XP_006629156  70 LQR-EAAGRPgLHETGAVLGEEEAALQEA------DSGVLRLAEGDPFPR---EHTVVWLGVQALGFVLVCEAHENLLLA 139 spotted gar
XP_006005779 138 ENTLRTVTKYLLEYLKPLSQG-SEI---LLKADKIEVILNRFLPHGQLLFINHRFVHSLEKELS 197
XP_016283704 138 ESTLRLLTRLLLEHLKLLSSG-SNV---LLRGDRIEAILNHFLPQGQLLFLNDQFVQALEKELS 197
XP_003227913 173 ECALRSVARSLLDHLHLLGSG-SEV---LLKADRTEAVLARFLPHGQLLFLNDQFVAGIEREVA 232
XP_003447889 136 EGTLRNLTRHCLEHLHMLGQG-SEV---LLKSNRIDVLLSRLLPHGQLLFLNHRFAQSLEKEVA 195
XP_007237315 135 EGTLRNLTRHCLEELRLLGTG-SEV---LLKSDRVDAMLQRLLPHGQLLFLNNRFAQNLDKELS 194
NP_001292497 132 EGTLRNIARHCLEELRLLGPG-AEV---LLKSDRVDALLHRLLPHGQLLFLNHRFAFNLEKEIS 191
XP_002416012 140 GQILRQIIHSISCHVVFVTP--SEL---LAKAGLVHAIVKLYLPAGKLLFVNQNVVKQYEQLLQ 198
CAQ39486     135 DYFLHTFINALREQHDSVKRKkCKSnmeLFHPDTVLAVLYFFLPKGQLLLMNENHANFLNSQVK 198
XP_004991672 127 QQTLSRFVQHLTTLSRAAKTQtIKL---RDKTAQMDAYLKVFLPQGQAILFNSKTQQLLHKQVD 187
EEN44006     128 AATLSQIFRLLRQHLRVLTQP-EEV---LQKADRVAAILHHFLPQGQLLFLNSRAVRHKEKELE 187
XP_003730604 133 ENQLRLLVKNLQEHVKAVRQP-IEV---LEKGDRVMAVLHHFLPSGRIIFMNHALIKQTEKELD 192
XP_011438995 127 ENVLKILIRFIQEHVRVINQP-SEA---RLKSDKIALILSRFLPNGNLLFMNHRVVRQLEKEVE 186
XP_006629156 140 EGTLRSLARHCLEHLRLLGTG-SEV---LLKADRIEVLLHRLLPHGQLLFLNHRFKHSLDKELG 199 spotted gar
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