6GBI,6IB6


Conserved Protein Domain Family
TFP_LU_ECD_LYPD6
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cd23625: TFP_LU_ECD_LYPD6 
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar proteins
LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467145
Aligned: 9 rows
Threshold Bit Score: 148.009
Created: 1-Nov-2017
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6GBI_A         3 GFKCFTCEKAaDNYECNRWAPDIYCPRE---------------------------------------------------- 30  human
XP_006003862  46 GFKCFTCENAsDNYECNRWAPDVYCPRG---------------------------------------------------- 73  coelacanth
NP_001106503  46 GFKCFTCEKAaDNYDCNRWAPDIFCPRE---------------------------------------------------- 73  western clawed ...
Q66IA6        46 GFKCFTCEDApDNYECNRWAPDLYCPRE---------------------------------------------------- 73  zebrafish
NP_001279650  46 GFKCFTCEKApDNYECNRWAPDIYCPKE---------------------------------------------------- 73  elephant shark
Q86Y78        46 GFKCFTCEKAaDNYECNRWAPDIYCPRE---------------------------------------------------- 73  human
6IB6_A         1 MFKCFTCEKAaDNYECNRWAPDIYCPRE---------------------------------------------------- 28  
CBY07670      34 AFRCFTCDNAvDNYECNNHAPDVFCPAE---------------------------------------------------- 61  Oikopleura dioica
KAB1278773    46 GFKCFTCEKAaDNYECNRWAPDIYCPREsqtkrnleiedaypfgssfyavhyfsvkvkrnlgmplaalslsvtwqvgltf 125 Arabian camel

6GBI_A        31 ------------TRYCYTQHTMEVtGNSISVTKRCVPLEECL--STGCRDSehEGHKVCTSCCEGNICNLPLPRN 91  human
XP_006003862  74 ------------TKYCYTQHRMDSnGMSISVTKQCMSLEGCM--STGCSETklEGHKVCTSCCEGNICNLPLPWN 134 coelacanth
NP_001106503  74 ------------TRYCYTQHIMNAtGESVSVTKRCAALEHCL--NSGCRDSinKDQKVCTSCCEGNICNLPLPRN 134 western clawed frog
Q66IA6        74 ------------SRYCYTHHKMSWdGNTVSVTKRCVPLEDCL--QTGCSDIdhEGNRVCTACCEGNICNLPLPRN 134 zebrafish
NP_001279650  74 ------------TRYCYTRHKMNDnGDSVLVTKRCVPLEKCL--FVGCTGPdyEGNKVCTSCCEGPICNLPLPRN 134 elephant shark
Q86Y78        74 ------------TRYCYTQHTMEVtGNSISVTKRCVPLEECL--STGCRDSehEGHKVCTSCCEGNICNLPLPRN 134 human
6IB6_A        29 ------------TRYCYTQHTMEVtGNSISVTKRCVPLEECL--STGCRDSehEGHKVCTSCCEGNICNLPLPRN 89  
CBY07670      62 ------------TEFCFTEHVFKEeTDSIRVRKSCMTRNKCHeqELGCQTDpiSGHTTCKECCQGEICNLPVPKT 124 Oikopleura dioica
KAB1278773   126 aisiklyfllteTRYCYTQHTMEVtGNSISVTKRCVPLEDCL--STGCRDSehEGHKVCTSCCEGNICNLPLPRN 198 Arabian camel
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