Conserved Protein Domain Family
Vfa1
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pfam08432: Vfa1 
AAA-ATPase Vps4-associated protein 1
Vps Four-Associated 1, Vfa1, in yeast, is an endosomal protein that interacts with the AAA-ATPase Vps4. It would seem to be involved in regulating the trafficking of other proteins to the endocytic vacuole. There is a CCCH zinc finger at the N-terminus.
Links
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Statistics
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PSSM-Id: 429993
Aligned: 87 rows
Threshold Bit Score: 93.1624
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CCK69965       3 NEYIKRRVATKDSQLCMICQKPTTTVLFNQSGq-----DWIYTCELHLQNnPQFVTPSYSQeYHDAVENCKNNREALTKL 77 
XP_002553775   3 NQYTKRKVAPRDARSCLVCLKPTACVLYNASIq-----DWFHCCELHLQDnPQFAKPVYPAgYQDALGQLAELKRTLDAQ 77 
XP_003648485   3 NVYTKRKVSAASASTCLVCLKPTTTVMYNKSGq-----DWFYCCDLHILDnPQFAQPIYTShYKERLKRVNELGAKLGSH 77 
Q75CH1         2 DKYAKRKVAARDAGGCLICDSRTVTVLHCAASg-----DWFFCCDLHLQDnPQFAQPNYTPaYHAACRRVADLASRLAAS 76  Eremothecium go...
EDO17805       3 NEYVARQVALKDTQPCIICSKPSTTVLYNGSGp-----DWFYSCNIHLVDnPQFVVPMYTQeYYSSLEELKRLKQESNSL 77 
CCH60729       3 NEYVKRKVALKDIQPCLICNKPSTTVLFNGDNnngggaDWFYVCDIHLQDnIQFVVPVYSKeYENEVIHLRQLKQKITST 82 
XP_002498808   3 NEYTARKVGIKDMQPCVVCYKPTTTVLY--SGi-----DWFYTCDIHLQDnPQFVTPLYSKeYQDAVAKLKALKPLPATN 75 
CCD23284       3 NEYVSRKVSLKDINGCLICQKPTTTVLYNKSGp-----DWFYTCDIHLQDnPEFVKPIYGKdYETKTNRLKSVQQELHRI 77 
CCF56511       3 NEYVRRKVGIRDMKSCLICQKPTTVVLYNKSIp-----DLIYSCEIHLQDnPQFVLPIQSTeYIRTVERLKILKRELAVA 77 
XP_003674913   3 NEYACRKVALRDTKSCLVCHKPSTTVLYNKSGp-----DWFYTCDIHLQDnPQFATPVYDKeYENVLTKMKSLKNELNSN 77 

CCK69965      78 KNNNStdSSSWdtwvnrlftkKQENdkakpkeseiLNSELPTNTRDDKGSNPTNpakspdiqsqINDLQGQYDAALEKML 157
XP_002553775  78 RVHGS---GSWdtwvnklisrKPKSendkdkepgkEPSKDPDEEPGKGSDKEPSp--------aGDDAACAYQQALDRVA 146
XP_003648485  78 SATHS---GNWdswitnlftsAKVAp--------pETKSQPNSEKPPADPADAEpk------etLSQLKLQYDKELSAVA 140
Q75CH1        77 EKAAA---AGWdswlgrfaasKKKPavpakdgnvsAQGQDKTEDKEEKPAEVSAa-----------DLRREYERELATVA 142 Eremothecium go...
EDO17805      78 TQEDL---SSWdgwvtkifnkKPKE-------------DSKEKEKEKEQEKVKEkestesvvdrSSELKNEYRKALDRLS 141
CCH60729      83 AAIKN---GNWdgwvtklfakGTKSstktdnieadSAIDADNEDKGTKGQDTKApa-------dLSALQREYDETLDRIT 152
XP_002498808  76 SG------SGLdgwvskflkkDKKEk---------HNGGDGDGNGDGDGDGEKTtkd----kdqGQELQRQYDEQLDLVS 136
CCD23284      78 QKNND--PSSWdgwvgklfikKNKNqs-------pDKDKDKDKDENKDGDNNNNkvgnestgnrSDMLQREYQTLLDELT 148
CCF56511      78 NDNDK--TGSWdnwvtkifssKKSEg-----------eVDDDNSKKANDSATPSp--------dQADPRKEYNELLDRMA 136
XP_003674913  78 AGASG---SSWdswvskvfikMD---------------KDADKPKDTDPANTPEpav-----rtQAQIQEEYNATLDTLT 134

CCK69965     158 TLQKSNksFKLSDKMFALRLENRrekqrAQERKRREEENYSNtDPEQmqs-qfsFPEVPK 216
XP_002553775 147 RYRKNLrtYSLSQIMFESRLEAQkraeaLKQRRQREQEAYTNtDPDElqa-kfaFPSVPR 205
XP_003648485 141 DIKKNTrtYSLSQVMFESRQQRLkhlsnVKEQNRMHQEAYSNtDPEDllk-rynFPELPK 199
Q75CH1       143 TLRNKPatYTLSAVMLTSRLERRtrvaaRAERAREEEQAYSNtDPQQllq-tyhFPELPK 201 Eremothecium gossypii
EDO17805     142 ELQKKNkkYKLSQIMFESRTQLKqkqaaIAELKRKEAESYTNtEPDElln-kysFPDIPN 200
CCH60729     153 KLQKNNktYQLSDTFYQSRLERKkqqekLAARRKQLQESYTNtDPDElls-kfaFPSVPK 211
XP_002498808 137 KLQRQNrkYQLSRTVFDSRIQRKqmetkWKEQKRIEDESYTNtDPLElet-kfvFPSVPK 195
CCD23284     149 HLKQNNrkYQLDNSLYENRVQRR-------IRTQRIKETYTAtNPEElaqrlatFPNVPT 201
CCF56511     137 QLQNDVrlFKLSKSMFESRIHQRqmmlkRIELQKREEQSYSNtDPDEltt-sfnFPSTPT 195
XP_003674913 135 TLRKKNkmYQLSPQMFESRVQLKkreemLKEQRRKQEEAYTNtDPDEllt-kfsFPQVPN 193
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