Conserved Protein Domain Family
Anp1

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pfam03452: Anp1 
Anp1
The members of this family (Anp1, Van1 and Mnn9) are membrane proteins required for proper Golgi function. These proteins co-localize within the cis Golgi, and that they are physically associated in two distinct complexes.
Statistics
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PSSM-Id: 427303
Aligned: 126 rows
Threshold Bit Score: 216.98
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006685639  86 DFEYYDLNSFTGSA-QG-MKNQDVVLFLMPLrnaEHV-----LSMAFHNIMNLT---YDHSLIDIAFLVSDCSEGDTTLE 155
XP_011276987 153 ktyTFKTNNKENPN-DNiDGEKNDLVILSAVtqqIDSkd-gkFNNFLALLEGLD---YPNSKTSLSILLSSKDEFKKFDE 227
EMG50246      96 TSSKYQFEETNGET-NI-DPSKDTILVMSVIgnsAPYgkdreFSHFIQTILTLVe-nQPNYIFSLALLSNNDDEFSRIQG 172
CCE39652     136 qkkeHKL-QPTNKY-TT-INENPSVLILSAIgkdQPYgkdrlFSDFMKTIHTIIe-nQPDLQFNLGLSSNYLTEFENIQK 211
XP_001524121  85 kkiTYTLKQAENEK-VS-SSQKPTVLIVSSVgkdEPYgpgrsFELFMDTILTLIdntDSKYQFSLGLQNNHLAEFNKIES 162
ABN65744      71 qrsnGNIPVKNSPF-DD-RKTRPTVLIVSTIasnSGYgegrtFVDFFDTISTLYq--HDTHDISLAFLINSASEFSKVET 146
EDK37041      52 AFNYTKITYVNNDT-PK-TLADDSLLFVATIansESYgpgrqFQDFFSVIKSFD---YDENAISLGFYFGDESEFNTVDK 126
EPB83249       3 HHNYMDLNDLNSTR-FG-KEANEHVLVLTPLqndEQY-----LDHYFELLDKTN---YPNHLISIGLLVSDST--DDTLE 70 
EPB88649      62 nhlfTNFNHITSSAnHA-QRNKEKILVLTPLkdaSPY-----LDQYFKLLDETS---YPNHLISLAFLVSDSS--DNTLE 130
EIE81055      67 kpsLIDFNQITASA-DA-KRNKEKILVLTPLkdaAGY-----LDRYFELLDRTR---YPNHLISIAFLVSDSS--DGTLE 134
XP_006685639 156 KTFEYSVALQngtlvdklqreeaikakyrrgssdlyqlymdqdymnnvrksynpryYHKDy-----sKPFRSITIYRKDF 230
XP_011276987 228 YVAKIFKEIE------------------------------------------------NTkdleslkNSFSKITLMNAQF 259
EMG50246     173 FFEDETNDLGll------------------------------------------------------sSIFESISIISAPF 198
CCE39652     212 FIDENDAQYF---------------------------------------------------------KYFNTITIVSAPD 234
XP_001524121 163 HIAAKLESLA---------------------------------------------------------TKFHKITLSSAPQ 185
ABN65744     147 IFNTNSSIYEn--------------------------------------------------------PALRKVTLLSAPF 170
EDK37041     127 YIHHYFASVK-------------------------------------------------Annq--naPSVNKVTILFAPF 155
EPB83249      71 KLYNTVHRLQ----------------------------------------------NRWR-------NRFYEIDVYQKDF 97 
EPB88649     131 SLQSHINDIQ----------------------------------------------SRWNy-----rHRFESVRIFKKDF 159
EIE81055     135 LLEYHARRLQ----------------------------------------------RRWS-------NRFESIRIFQKDF 161
XP_006685639 231 GQA--IGQ----GFSDRHAVKVQGIRRKLMGRARNWLTTNALKPYHSWVYWRDVDIE--TCPGSVIQDLMKHDYDVMVPN 302
XP_011276987 260 IEDef-----kiDRANRQKPEAQKQRRKLLARLRNFLVFNGIGAE-IYSLSVDSDMI--ELPKDLITTFIESGKDIVTIR 331
EMG50246     199 LDQnt-----gfSREERHKDSVQRLRRRLIAKSRNFIMLNALESQ-QYILTIDSDMVrfDEAAKIIPTFVNSDKDIIVPR 272
CCE39652     235 LEQtaSGDdeelSRDNRHDDRKQRMRRRLIARCRNYLVSNALTSE-AYTLFIDSDIVefEHASKFIQFLIGSKKDIIVPR 313
XP_001524121 186 LEge------gvSRNDRHNDAMQRTRRRLIARSRNFLISQALADE-QYIITLDSDIIgfEQGPKMLEIMINSNRDIIVPR 258
ABN65744     171 LEEns-----gfSRDQRHNDNVQRLRRRLIARARNFVLYTALHQE-QYTLFLDADIIklDHSDKVISTFINSKKDIIVPR 244
EDK37041     156 LEKdyNSI----DRSQRHNDNVQRLRRRNIARTRNFALLHTLAEE-RYTVFMDADVVaiKNP-DMIHQFIASKKDIIVPR 229
EPB83249      98 ------------RLDEKPNDTSLNSRRATLARAKNFLLTAALREHHSWVAWVDVKLH--SYPPTIFSDLMLVDGDVVVPN 163
EPB88649     160 D----FDL----PSSRRHEYEMQPLRRSILARSRNWLLSAALKSDTSWVAWIDIDVV--EYPTSIFQDLMRADADVVVPN 229
EIE81055     162 D----FDL----PNEKRHRYEMQPLRRRVMARSRNWLLSASLRHDISWVAWVDVDVV--EYPPTIFEDLIRADVDVIVPN 231
XP_006685639 303 VWRPLPSfLV-DeppfEQPYDLNSWI--ESDPALELASKLDEDDVIVEGYA-E-YPTWRVHLAYIRD--RN-------GD 368
XP_011276987 332 VDM-----KNsAghvvHKDFDLNSWAgdRKTPTPEQ--DADPNLFFEPGPGpNkIQFSDIHk------nPSkyg-lkrSD 397
EMG50246     273 IERPG-----------LRDYDKNSWRgeRTKPNQEQLDKMDNNDWEHWGYVpRdVKANMYHFQTYLDnkDNeyd-lhkDE 340
CCE39652     314 IRRGD-----------LSDYDRNSWRgkRTKPTLEQLQLMDENKWDQFDYVpRdIESEMFHFF-NLDnkDelt--idqQK 379
XP_001524121 259 VTRGG-----------ISDYDRNSWRgkRTKPLQEELDLMDANKWGEFRYVpRdVQGEIYHFYMHVDsqlt----deqKQ 323
ABN65744     245 IIRDG-----------NQDYDKNSWRgqRTKPDENQLEKMDDDRWEQWDYVpRdVPGKMYHFQNYVDnkNNere-qhlHE 312
EDK37041     230 VIRGS-----------LIDYDRNSWVgeRTVPNEEQLLKMDQNDWEHWDYVpLdVPGKMIHFQDLIEqqEQtppddvsRR 298
EPB83249     164 CLLKRQDdE-------FWGFDRNNWQ--ESDLSLERQQNAAEHEVLMEDYN-Q-YSIGRHLLVDMPT------------H 220
EPB88649     230 CLLKRDDqA-------FWAYDKNNWQ--ETDESKRIQEGLDEDFVLLEGYY-E-FPTYRYLMVDMPT---D-------VD 288
EIE81055     232 CLLSRQDhA-------FWAYDKNNWQ--ETDASRFRQRDLDEEFVLLEGYY-E-FPTYRYLMVDMPT---D-------VS 290
XP_006685639 369 PNEAVDLDGVGGVSILAKAKLFRQGVHFPAFT 400
XP_011276987 398 KKSLFELNSVGGAVLFVKTEIFKQGIMFPPYy 429
EMG50246     341 YEYIIPLDSVGGAILFMKSIVVKQGVIFPTSl 372
CCE39652     380 LSYMVELDSVGGAVLFFKSYIFKQGAIFPTSy 411
XP_001524121 324 LNYAVPLDSVGGAVLFFKSIVFKQGANFPTSy 355
ABN65744     313 FEYAVPLDSVGGAVLFAKSVIYKQGVVFPTNy 344
EDK37041     299 PDYIVKLDSVGGAILFAKSMIYKQGVVFPPNy 330
EPB83249     221 QGTRIPLDGVGTTFTLVKATVHREGAVFPPFv 252
EPB88649     289 KDYKVELDGVGATFTLVKAHVHREGANFPAFT 320
EIE81055     291 PDYKVPLDGVGATFTLVKANVHREGAIFPAFT 322
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