2PL5,2B61,2VAT


Conserved Protein Domain Family
homoserO_Ac_trn
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TIGR01392: homoserO_Ac_trn 
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homoserine O-acetyltransferase
This family describes homoserine-O-acetyltransferase, an enzyme of methionine biosynthesis. This model has been rebuilt to identify sequences more broadly, including a number of sequences suggested to be homoserine O-acetyltransferase based on proximity to other Met biosynthesis genes. [Amino acid biosynthesis, Aspartate family]
Links
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Statistics
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PSSM-Id: 273596
Aligned: 19 rows
Threshold Bit Score: 490.282
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2PL5_A    16 EFKELILNNGSVLSPVVIAYETYGTLSSs---KNNAILICHALSGDAHAAgyhSgsdk-----------kpgWWDDYIGP 81  Leptospira interrog...
O53391    21 DVGSLQLESGAVIDDVCIAVQRWGKLSPa---RDNVVVVLHALTGDSHITgpaGpghp-----------tpgWWDGVAGP 86  Mycobacterium tuber...
AAP21656  33 REKPLPLEAGGELPGARLAFETWGRLASd---ASNAVLVLHALTGDSHVAgpaGpghp-----------tpgWWDRLIGP 98  Streptomyces hygros...
O68640    14 AIGDVSTEAGAIITNAEIAYHRWGEYRVdkegRSNVVLIEHALTGDSNAAd---------------------WWADLLGP 72  Corynebacterium glu...
CAD78525  46 FDQSLPLERGGELPEIRCCYETWGTLNDd---GSNAVLVCHAVSGDSHAAr-hDedd------------qpgWWDGLIGP 109 Rhodopirellula balt...
P57715     5 ELDGFTFACGDTVDSLTVAYRTYGDYTG-----SNAVLVCHALTGSQHVRgraDgdd-------------rgWWPDIVGP 66  Halobacterium sp. N...
Q9RA51    39 RREGFYTELGGYLPEVRLRFETYGTLSRr---RDNAVLVFHALTGSAHLAgtyDeetfrslspleqafgregWWDSLVGP 115 Thermus thermophilu...
O60062    36 IVPKFTLECGDILYDVPVAFKTWGTLNKe---GNNCLLLCHALSGSADAG---D------------------WWGPLLGP 91  Schizosaccharomyces...
P39058    79 RISLFTLESGVILRDVPVAYKSWGRMNVs---RDNCVIVCHTLTSSAHVT---S------------------WWPTLFGQ 134 Acremonium chrysogenum
P08465    35 QVPELVLESGVVINNFPIAYKTWGTLNEa---GDNVLVICHALTGSADVA---D------------------WWGPLLGN 90  Saccharomyces cerev...

2PL5_A    82 GKSFDTNQYFIICSNVIGGCKGSSGPLSIHpe--tsTPYGSRFPFVSIQDMVKAQKLLVESLGIEKLFCVAGGSMGGMQA 159 Leptospira interrog...
O53391    87 GAPIDTTRWCAVATNVLGGCRGSTGPSSLArd---gKPWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGGARA 163 Mycobacterium tuber...
AAP21656  99 GRALDTDRWFVVAPNVLGGCQGSTGPSSLTpd---gRRWGGDFPFLTQRDQVAVEADLADALGIDRWALVVGGSMGGMRA 175 Streptomyces hygros...
O68640    73 GKAINTDIYCVICTNVIGGCNGSTGPGSMHpd---gNFWGNRFPATSIRDQVNAEKQFLDALGITTVAAVLGGSMGGART 149 Corynebacterium glu...
CAD78525 110 GLPIDTDRLFVVCPNVLGGCRGSTGPGDADptspdgKPYGANFPRITIGDIVEAQKLLADHLGIRQWRAVVGGSLGGHQV 189 Rhodopirellula balt...
P57715    67 GRPIDTTEYFVVCANVPGSCHGTDGPPADGpg---gDPWGTAFPPVTVPDWTRCQRRLLDTLGVDRLHAVVGGSVGGMNA 143 Halobacterium sp. N...
Q9RA51   116 GRILDPALYYVVSANHLGSCYGSTGPLSLDph--tgRPYGRDFPPLTIRDLARAQARLLDHLGVEK-AIVIGGSLGGMVA 192 Thermus thermophilu...
O60062    92 GRAFDPSHFFIVCLNSLGSPYGSASPVTWNae--thSVYGPEFPLATIRDDVNIHKLILQRLGVKQIAMAVGGSMGGMLV 169 Schizosaccharomyces...
P39058   135 GRAFDTSRYFIICLNYLGSPFGSAGPCSPDpdaegqRPYGAKFPRTTIRDDVRIHRQVLDRLGVRQIAAVVGASMGGMHT 214 Acremonium chrysogenum
P08465    91 DLAFDPSRFFIICLNSMGSPYGSFSPLTINee--tgVRYGPEFPLCTVRDDVRAHRIVLDSLGVKSIACVIGGSMGGMLS 168 Saccharomyces cerev...

2PL5_A   160 LEWS-IAYPNSLSNCIVMASTAEHSAMQIAFNEVGRQAILSDPNWKNGLYDENS--PRKGLALARMVGHITYLSDDKMRE 236 Leptospira interrog...
O53391   164 LEWV-VGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGraPDAGLRLARRFAHLTYRGEIELDT 242 Mycobacterium tuber...
AAP21656 176 LEWA-VSYPERTGALLLLASTAAASAEQIAWANIQVHAIRADPHWRGGHYHDTGqgPHAGLGLARRLAHVTYRSEPELAV 254 Streptomyces hygros...
O68640   150 LEWA-AMYPETVGAAAVLAVSARASAWQIGIQSAQIKAIENDHHWHEGNYYESGcnPATGLGAARRIAHLTYRGELEIDE 228 Corynebacterium glu...
CAD78525 190 LQWI-NRYPDAAKTCVAIATSPRLNSQALGFDVIARNAIQTDPHYAGGQYYDKDqrPDTGLAIARMLGHITYLSVEAMEA 268 Rhodopirellula balt...
P57715   144 LDWA-RRYPDDVHRIAAVATAPRLDAQCLGLNAIARRAIRGDPNWNDGDYYG-GahPDRGLALARQLGHVMYLSKASMAD 221 Halobacterium sp. N...
Q9RA51   193 LEFA-LMYPERVKKLVVLAAPARHGPWARAFNHLSRQAILQDPEYQKGNPAP------KGMALARGIAMMSYRAPEGFEA 265 Thermus thermophilu...
O60062   170 LEWA--FDKEFVRSIVPISTSLRHSAWCISWSEAQRQSIYSDPKFNDGYYGIDDq-PVSGLGAARMSALLTYRSKCSFER 246 Schizosaccharomyces...
P39058   215 LEWA-FFGPEYVRKIVPIATSCRQSGWCAAWFETQRQCIYDDPKYLDGEYDVDDq-PVRGLETARKIANLTYKSKPAMDE 292 Acremonium chrysogenum
P08465   169 LEWAaMYGKEYVKNMVALATSARHSAWCISWSEAQRQSIYSDPNYLDGYYPVEEq-PVAGLSAARMSALLTYRTRNSFEN 247 Saccharomyces cerev...

2PL5_A   237 KFGRNPPRGN------------------------------------------------ILS------------------- 249 Leptospira interrog...
O53391   243 RFANHNQGNE------------------------------------------------DPTa------------------ 256 Mycobacterium tuber...
AAP21656 255 RFGRTPQGTE------------------------------------------------DPWs------------------ 268 Streptomyces hygros...
O68640   229 RFGTKAQKNE------------------------------------------------NPLgpyr--------------- 245 Corynebacterium glu...
CAD78525 269 KFDPDRHDPR------------------------------------------------QIAsq----------------- 283 Rhodopirellula balt...
P57715   222 KFGRRTATTDtal-------------------------------------------paDPAae----------------- 241 Halobacterium sp. N...
Q9RA51   266 RWGAEPELG----------------------------------------------------------------------- 274 Thermus thermophilu...
O60062   247 RFARTVPDASrhpypdrlptpltpsnahwvvhnegnrnrrerpcrsngssptsesalnSPAssvsslpslgasqttdsss 326 Schizosaccharomyces...
P39058   293 RFH-MAPGVQagrnissq---------------------------------dakkeinGTDsgnsh-------------- 324 Acremonium chrysogenum
P08465   248 KFSRRSPSIAqqqkaqreetrkpstvsehslqihndgyktkastaiagisgqkgqsvvSTAsssdslnsstsmtsv--ss 325 Saccharomyces cerev...

2PL5_A   250 ------------TDFAVGSYLIYQGESFVDRFDANSYIYVTKALDHYSLGKG---KELTAALSNATCR-FLVVSYSSDWL 313 Leptospira interrog...
O53391   257 -----------gGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGr--GGVSAALRACPVP-VVVGGITSDRL 322 Mycobacterium tuber...
AAP21656 269 -----------gGRYQVESYLDHHAAKLVRRFDAGSYVVLSEAMNSHDIGRGr--GGIRAALRQVTAR-TLVAGVDSDRL 334 Streptomyces hygros...
O68640   246 ---------kpdQRFAVESYLDYQADKLVQRFDAGSYVLLTDALNRHDIGRDr--GGLNKALESIKVP-VLVAGVDTDIL 313 Corynebacterium glu...
CAD78525 284 ----------feQRFSIGSYLAHQGQKFTTRFDANSYVTLSMAMDLFDLGGt--rLKLMETFDEATCD-FLLISFSSDWL 350 Rhodopirellula balt...
P57715   242 ----------ffATRDVESYLDYQADTFVARFDANSYLYLLRAMDAYDLAAGr--PSVADALAAFDGD-ALVLSFTGDWH 308 Halobacterium sp. N...
Q9RA51   275 -----------------ETYLDYQGEKFLRRFHAESYLVLSRAMDTHDVGRGr--GGVEEALKRLRAIpSLFVGIDTDLL 335 Thermus thermophilu...
O60062   327 lnqssllrrpanTYFSAQSYLRYQAKKFVSRFDANCYISITKKLDTHDITRGrgsDSPKEVMKDLSLP-VLVLGIESDGL 405 Schizosaccharomyces...
P39058   325 --------ragqPIEAVSSYLRYQAQKFAASFDANCYIAMTLKFDTHDISRGr-aGSIPEALAMITQP-ALIICARSDGL 394 Acremonium chrysogenum
P08465   326 vtgevkdikpaqTYFSAQSYLRYQGTKFINRFDANCYIAITRKLDTHDLARDr-vDDITEVLSTIQQP-SLIIGIQSDGL 403 Saccharomyces cerev...

2PL5_A   314 YPPAQSREIVKSLEAADKRvf-yvELQSGEGHDSFLLKN--PKQIEILKGFLE 363 Leptospira interrogans serovar Copenhageni str...
O53391   323 YPLRLQQELADLLPGCAGLr----VVESVYGHDGFLVET--EAVGELIRQTLG 369 Mycobacterium tuberculosis
AAP21656 335 YPPSQQAELASGIPTADDLr----LIESPYGHDGFLIEV--EQVAALVGELVR 381 Streptomyces hygroscopicus subsp. yingchengensis
O68640   314 YPYHQQEHLSRNLGNLLAMa----KIVSPVGHDAFLTES--RQMDRIVRNFFS 360 Corynebacterium glutamicum ATCC 13032
CAD78525 351 FPPAQSREIVNALTALDKRvt-yaEITTNAGHDAFLIAKdiATYGPLIRERLR 402 Rhodopirellula baltica SH 1
P57715   309 FTAAQSATVADAFRAGGAAgvahhVVDSDYGHDAFLVDS--AAVGPPLADFLA 359 Halobacterium sp. NRC-1
Q9RA51   336 YP---AWEVRQAAKAAGARy---rEIKSPHGHDAFLIET--DQVEEILDAFLP 380 Thermus thermophilus HB27
O60062   406 FTFDEQVEIAKSFPNATLE-----KIISAEGHDGFLLEF--TQVNSHIQKFQK 451 Schizosaccharomyces pombe 972h-
P39058   395 YSFDEHVEMGRSIPNSRLC-----VVDTNEGHDFFVMEA--DKVNDAVRGFLD 440 Acremonium chrysogenum
P08465   404 FTYSEQEFLAEHIPKSQLE-----KIESPEGHDAFLLEF--KLINKLIVQFLK 449 Saccharomyces cerevisiae S288c
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