Conserved Protein Domain Family
Endosulfine

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pfam04667: Endosulfine 
cAMP-regulated phosphoprotein/endosulfine conserved region
Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein.
Statistics
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PSSM-Id: 398375
Aligned: 29 rows
Threshold Bit Score: 88.521
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_036663390  21 DLSKLSPQELKIYRMYGKL-PTTQ-------QILSSKFH--DKKYFDSGDYAMQKQkgGALKNIsglgsGIGEGIPSR-- 88 
Q9XU56        16 ATGALSPEKQQEQELMGKLaATGKlparpasSFLQKKLQ--QRKFFDSGDYAMDKS-------------KAGTGLGSKph 80  Caenorhabditis ...
ACG42524       8 kSSASMEEEACGEKKYGGIaPKKK-------PLISKDH---ERAYFDSADWVLGKq--AA--NS-----STRATVESL-- 66 
XP_002276228  11 fPSSQDHEATSEVKKYGGLaPKKK-------PLISKDN---ERAFFDSADWALCKq--GAGMNQ-----KSTVAVETL-- 71 
NP_567486     11 FLFSQQQESTSGANKYGGLvPKKK-------PLISKDS---KRAFFDSADWALLKq--EASIDQ-----RTIAAIEKL-- 71 
XP_011627370  16 DIGSSQEEVSTLTKKYGGIvPKKK-------PLISKDH---ERAFFDSADWALDKq--GATQGQ-----QSRSDVVSL-- 76 
XP_009405661  22 AMPSAEQEEQAIKKKYGGIlPKKP-------PLISKDH---ERAYFDSADWALGKq--GGH-AQ-----KPKGPLEAL-- 81 
XP_015622478  28 SMPSAQEQELAIKKKFGGLmPKKP-------PLISKDH---ERAYFDSADWALGKSgqQG--AA-----KPKGPLEAL-- 88 
XP_016274402   9 DISSFSEQEKELFQKYGKV-PAHK-------NLLANKLK--ERKYFDSGDYAMSKA--GV---------SPPQSVGTA-- 65 
XP_006678062   4 DPSKLSDEDRAFFEKYGRLpPAKK-------AGLQQKLMggDRKYFDSGDYAMSQA--GK---------SSPNEVGSQ-- 63 
XP_036663390  89 ----HPSAERMKEMSVRNSISA 106
Q9XU56        81 plagGPPPAAPPVVAQRSPAPA 102 Caenorhabditis elegans
ACG42524      67 ----KPKLKRTPHHQLPPRKPT 84 
XP_002276228  72 ----RPKLQRTPHQRLPPRRPA 89 
NP_567486     72 ----RPKLQRTPRKQLSPRRPT 89 
XP_011627370  77 ----RPKLQRTPHQRLPLRRPA 94 
XP_009405661  82 ----RPKLQPTPQQQVRSRRSV 99 
XP_015622478  89 ----RPKLQPTRQQQQRSRRLI 106
XP_016274402  66 ----IPSPADIPHA-SPPSNQS 82 
XP_006678062  64 ----HPSPERIPHSIPQSFKKN 81 
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