Conserved Protein Domain Family
bHLH_TS_bHLHa9

cd18912: bHLH_TS_bHLHa9

basic helix-loop-helix (bHLH) domain found in Class A basic helix-loop-helix protein 9 (bHLHa9) and similar proteins

bHLHa9, also termed Class F basic helix-loop-helix factor 42 (bHLHf42), is a bHLH transcription factor that plays an essential role in limb development.

Links

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Source:	cd11390
Taxonomy:	Chordata
PubMed:	3 links

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl00081

Statistics

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PSSM-Id:	381482
Aligned:	6 rows
Threshold Bit Score:	85.3793
Created:	11-Jan-2012
Updated:	2-Oct-2020

Structure

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Conserved Features/Sites?
PubMed References ?

putative DNAputative dimer

Feature 1:putative DNA binding site [nucleic acid binding site]

Evidence:

Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
Citation:PMID 8181063

Scroll to Sequence Alignment Display

Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

Feature 1                #   # ### #    #                 ####                  
Q7RTU4        59 RPVRSKARRMAANVRERKRILDYNEAFNALRRALRHDLgGKRLSKIATLRRAIHRIAALSLVL 121 human
A3KNX5        58 RPVRSKARRVAANVRERKRILDYNQAFNALRVALHHDLsGKRLSKIATLQRAINRISALSVFL 120 zebrafish
XP_005999719  81 RPVRSKARRIAANVRERKRILDYNQAFNALRLALKHDLnGKRLSKIATLRRAINRISTLSMFL 143 coelacanth
OCT91129      49 RPVRSKARRTAANVRERKRILDYNQAFNALRQALKHDLgGKRLSKIATLKRAINRISTLSMFL 111 African clawed frog
XP_001235101  58 RPARSKARRMAANVRERKRILDYNQAFNALRLVLKHDLgGKRLSKIATLRRAIHRIAALSLSL 120 chicken
XP_002596737   9 RVVRSKAKRVAANVRERRRISEYNKAFNQLRISLNHPLsGKRLSKIATLRRAINRIQALRDSL 71  Florida lancelet

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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