2VQR,2W8S,2W8S


Conserved Protein Domain Family
PMH
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cd16028: PMH 
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Phosphonate monoester hydrolase/phosphodiesterase
Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Links
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Statistics
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PSSM-Id: 293752
Aligned: 24 rows
Threshold Bit Score: 552.25
Created: 7-Jan-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                ##                                            #                         
2VQR_A         3 KNVLLIVVDQWRADFVPHvlradgkidflKTPNLDRLCREGVTFRNHVTTCvPXCGPARASLLTGLYLMNHRAVQNTVPL 82  Rhizobium legum...
WP_010152696   3 RKVLLITADQFRFDHLGCtgh-----slkPTPNLDRLAAESSLFLKHFTNS-IPCGPSRASLHTGLYACNHRSVTNGTPL 76  SAR324 cluster ...
ADI23039       3 NSVLFICADQWRWDCFGFmgh-----khaHTPNIDKLVSRSTAFRKHFTGI-VPCGPARATMLTGLYPFIHRSVCNGTPL 76  uncultured Plan...
WP_020593376   7 RNILLITADQWRADCLSSagh------lvQTPNLDKLAADGLAFRKHFTQC-LPCGPSRTSLLTSMYAMNHRHVQNGTPL 79  Kiloniella lami...
XP_005973820   8 PNVLFICADQWRGDCLSAlgh-----pnvRTPNLDALAADGVLFRQHFGQC-TPCGPSRTSLLTGLYLMNHRSGRNGTPL 81  chiru
KGD49649       5 KNILFVMCDQLRWDYLSCygh-----palATPNIDALAQRGVRFERAYVQS-PVCGPSRMSYYTGRYVASHRAYWNFVPL 78  Burkholderia ps...
NP_251023      8 RNVLYIMCDQLRRDYLSCygh-----pylHTPNIDRLAAEGVRFARAYTQG-TICGPSRMSSYTGRYVSSHQVAWNAVPL 81  Pseudomonas aer...
EBA02400       1 MNVLWIMADQLRFDYLSCyga-----khiDTPNIDRLASKGVRFDKAYVQS-PICGPSRMSSYTGRYVRSHGATWNGFPL 74  Rhodobacteracea...
WP_019306843   3 KNILFIMCDQLRADYLSCygh-----pflETPNIDRLAERGVRFSNAYCQA-PLCGPSRASFYTGRYLSSHGAMANADPL 76  SAR324 cluster ...
WP_028820971   5 RNVLFVMCDQLRFDHLGFagh-----atiKTPNLDRFSKQCTRFTNAFVQA-GVCGPSRMSTYTGRYVSSHGVTWNRVPL 78  beta proteobact...

Feature 1                              # #                                                       
2VQR_A        83 DqrHLNLGKALRGVGYDPALIGYTTTVPDPRttspndp-----------------------rfrvlgdLMDGFHPVGAFE 139 Rhizobium legum...
WP_010152696  77 DrrHTNLALEVRKAGIEALLYGYSDTSVDPRhvnskdpsldtfesilpgfksvidfnlgylvgwldwlEDQGYDRPDPSE 156 SAR324 cluster ...
ADI23039      77 DkrFTSIPLEARKLGYQPSLYGYTDTSYDPRglekndp-----------------------rlftyesPMYGFDPVCHLP 133 uncultured Plan...
WP_020593376  80 DanFTNIAKEARKQGYDPILYGYTDTPADPRgraesdp-----------------------dlltyagVMPGFRVGSLVS 136 Kiloniella lami...
XP_005973820  82 DarHSNIALEARKAGYEPALFGYTDTSLDPRgrhp------------------------------ndpALTGYDKGVMPG 131 chiru
KGD49649      79 PvgELTLGDYLRPHGMRVALAGKTHMVPDAAgmqrlglvk--------------------gsdravllEECGFEPFDRDD 138 Burkholderia ps...
NP_251023     82 PleELTLGDYLRAAGVRTALVGKTHATANLEgmrrlgidp--------------------asargaalAEAGFEPYDRND 141 Pseudomonas aer...
EBA02400      75 RvgEPTLGDHLREIGVSCSLVGKTHMTPDFDgmkrlgidp--------------------estigalvSQCGFDEYVRDD 134 Rhodobacteracea...
WP_019306843  77 KlgELCLGDYLQKINYRTVLVGKSEARANQDalarllidq--------------------rsnlgqqlAQGGFEHYEHFA 136 SAR324 cluster ...
WP_028820971  79 PvgQLTLGDFLLAQSRSLDLIGKSHVIPDLVginrlgvlp--------------------qtklwkhlASGGFNELDRID 138 beta proteobact...

Feature 1                                                                                        
2VQR_A       140 Pnmegyfgwvaqngfdlpehrp-------------------diwlpegedavagatdrpsrIPKEFSDSTFFTERALTYL 200 Rhizobium legum...
WP_010152696 157 Svfhhspekit----------------------------------------egrfcdesafYAAEHSDTAYLTHHACHTI 196 SAR324 cluster ...
ADI23039     134 Esnpklwsdylkqhgykvekph-------------------elydsrhakkgegfvykaweIPTELSDTSFLADRAIADL 194 uncultured Plan...
WP_020593376 137 Eelaidwfgqleregirlpenqfd---------------itigspdypgakarghayappgYGKENSDTAFIADKLVDFI 201 Kiloniella lami...
XP_005973820 132 Fvtplhlpddmapngrgdvfr---------------------prpdfekpadrgfryiptiFPAEQSETAYLADRFLEWL 190 chiru
KGD49649     139 Gihpglfgkrvdtpycdylrskgyegdnpw---hdyansaegpngeilsgwkmrhaamparIREEDSETPYMIDRAMAFI 215 Burkholderia ps...
NP_251023    142 GvypddpafadkrerapythylrrlgftgdnpwhdwanaaagadgeilsgwrmrhaglptrLPEAHSETAYTTRRAMDFI 221 Pseudomonas aer...
EBA02400     135 Gtnainyknrhaedydrylrehgmdaevpw---eewantaigadgqkksgwflenaplparVPREHSETAWLTTRGIDFI 211 Rhodobacteracea...
WP_019306843 137 Giypeeivpddlayndylrsngydgenlw----eswansaydvngkkvsgwqmrnanlpaaVAEEHSETAFTTDRALEFL 212 SAR324 cluster ...
WP_028820971 139 Ghgapgpesgyanwlrnagyqsedpwnd-------yvvsghspngdkvsgwflrnvhlpslVSAEHSETAYVTEKALDYL 211 beta proteobact...

Feature 1                          #                                                             
2VQR_A       201 KGRd-GKPFFLHLGYYRPHPPFvaSAPYHAMYRPEDMPApiraanpdieaAQHPLMKFYVDsirrgsffqgaeg-sgatl 278 Rhizobium legum...
WP_010152696 197 RNYr-NEDWFIHISLLRPHPPLiaPAPYNHLYNWRELSLpergnslesdaALHPLLELWQQkidtldyfgsqa--nmlrl 273 SAR324 cluster ...
ADI23039     195 QNA--TEPFFMHISFLRPHPPFyvSEPWHSLIDPSSLEPpithgtkqemiSHHPILKNMMTryddensypsei--nysel 270 uncultured Plan...
WP_020593376 202 KVY--RQPWFVHGVFLRPHPPLfaPEPYNSMYDPSDVALphraetvgkeqRQHPYLEQALEkmaesgnymghey-nvrdl 278 Kiloniella lami...
XP_005973820 191 AVRd-EKPWFAHLVFYRPHPPLiaPEPYNRIVDPADVTLparaasltqekRQHPLLAYELDrlsepglydehspldpvsa 269 chiru
KGD49649     216 REQg-DRPWCLHLSLIKPHWPYivPAPYNDMYGPQDVKPversm--aereTQHPVYAAFMKheesvsfs----------- 281 Burkholderia ps...
NP_251023    222 DEQg-ERPWCLHLSYIKPHWPYiaPAPYHALYRADQVLPalraa--pgeeSDHPVYRAFREhreslnfs----------- 287 Pseudomonas aer...
EBA02400     212 ESQg-DDPWLCHLSYIKPHWPYlaPAPYNDMYSKDDLPPvnrr----dgeHTHPLMQAWEKtricesfs----------- 275 Rhodobacteracea...
WP_019306843 213 SGVdpNDQWCLHLSYIKPHWPYlvPAPYHSLYCKDQILPvvrnp--delqAPHPVFKAFHEqtysqnfs----------- 279 SAR324 cluster ...
WP_028820971 212 KDRv-GKKWVLHLSYVKPHWPYiaPAPYHNQYTANDIQPvsrnh--keliNPHPVYAAYLNqeesltfs----------- 277 beta proteobact...

Feature 1                                                     ##                                 
2VQR_A       279 deaelrqMRATYCGLITEVDDCLGRVFSYLDEtGQWDDTLIIFTSDHGEQLGDHHLLGKIGYNDPSFRIPLVIKDAGena 358 Rhizobium legum...
WP_010152696 274 cdedilrAKAVYLGLITEVDKNLGKVFDLLKEtGQWDETLIIFTSDHGEQLGDHHLWGKGGCFDQSWHIPLILRNPKnpa 353 SAR324 cluster ...
ADI23039     271 tkqdiarIQAVYLGMCAEVDSNIGKILQALDDsGQADNTMVIFTSDHGEMLGDYWQWGKNGWWDQSYRIPLIVHTPNcke 350 uncultured Plan...
WP_020593376 279 pdheiqqMRAAYYGLISEVDDQLGRVIQTLKDtDQYDNTLIIFTSDHAEQLGDHWLWGKLGYFDESCHIPLIIRDPRkea 358 Kiloniella lami...
XP_005973820 270 eeleirqMRATYYGLIAEVDHHIGRIVAHLKRtGEYDRTLIIVTSDHAEMLGEHHAWGKEIYFDGAFHLPLVIRDPRaea 349 chiru
KGD49649     282 rdevrntVIPTYMGLVKQIDDHLGRLFAFLREtGREDDTLIVFTSDHGDYLGDHWLGEKELFHDAASRVPLIVVDPRraa 361 Burkholderia ps...
NP_251023    288 redvrrqVIPTYMGLIRQVDDQLGRLFQHMRAsGRWDDTLIVFTSDHGDFLGDHGLGEKEFLLESAVGVPLLIRDPRpea 367 Pseudomonas aer...
EBA02400     276 rndvrdlVAPVYMGLIKELDDNLGRLFEYLETsGRMKDTMIVFCSDHGDNMGDHWLGEKDLFYDCSARVPMIVYDPRtea 355 Rhodobacteracea...
WP_019306843 280 rdevrerVVPTYMGLIKQIDDHLGRVFEMLKSkKLMDSTLIVLTADHGDYLGDHWLGEKDLFHEPSVRIPLIVCDPEtya 359 SAR324 cluster ...
WP_028820971 278 kqetvdqVRPVYMGLIEQLDSEFGRVLKQLEEsGELSNTLIIFTSDHGDLGGDHFLGEKDLFYDQVVKVPLMVFDPRqha 357 beta proteobact...

Feature 1                                                                                        
2VQR_A       359 ra---gaieSGFTESIDVMPTILDWLGGk-IPHACDGLSLLPFLSEGRPQdwrtelhyeydfrd-vyysepqsflglgmN 433 Rhizobium legum...
WP_010152696 354 sh---gitvSAFSEHVDITPTILAWLDQe-IPLAMDGRSLLPILQSEIPKdwktgifcefdwrs-lpqrhvqrdedrrfE 428 SAR324 cluster ...
ADI23039     351 ------qliDQMTESVDIAPTIIDWLDGd-IPADWNGRSLLSIVENTQPQlpprefvifewdfrelyytdfveklklapE 423 uncultured Plan...
WP_020593376 359 dasrgqtveSHFTEAVDIMPTVLDLIDGt-VPMQCDGHSLRCFLEGEQPEkwrsevhweydfrd-lknfsleqkfdltsD 436 Kiloniella lami...
XP_005973820 350 dag-rgstvDALTEAVDIMPTILDWLGLe-KPRACDGRSLMPLLHGATPTdwrdavffehdfrt-vatqkvemalgiasD 426 chiru
KGD49649     362 dtt-rgtvePRLVEAIDLLPTFLGAAGVeiPMHIVEGRSLQPLLHGAKDTpwreavfsefdys---frtrtrtllgrdlD 437 Burkholderia ps...
NP_251023    368 dat-rgrveEALVQSIDVLPSILEAFAVepASHRIEGRSLLPFVHGAPPAdwrryaiaeydya---fqaparerlgrpiD 443 Pseudomonas aer...
EBA02400     356 dat-rgtatDKLIEAIDLAPTFHEFFGGeaKPHVMEGRSLQPLLHDQDVSwreyciseydys-----trdardglgidqS 429 Rhodobacteracea...
WP_019306843 360 est-rgtvnHEFVEAVDIVPTMVEFAGGniCKQRMEGQSLLPLTRGILDQdnkreytisqidy---sdrgprvslnlhpY 435 SAR324 cluster ...
WP_028820971 358 nsm-rgravDELVESIDIVPTILDALGMptSDKPLQGFSLLPFLNRVEAPikrdfvisqidys----frkarltlnrqaN 432 beta proteobact...

Feature 1                                                                        
2VQR_A       434 DCSLCVIQDERYKYVHFaalpPLFFDLRHDPNEFTNLADDPAYAALVRDYAQKALSWRLKHADR 497 Rhizobium leguminosarum bv. vic...
WP_010152696 429 NQQLCLWRDNDFKYVHFakhpPLLFDLKNDPYETTNLAADPAYLSTCNKYLSTVLQHRMRHSDR 492 SAR324 cluster bacterium JCVI-S...
ADI23039     424 ECNLAVIRSNEWKYVHFpafpPLLYDLKNDQYEKDNLASDPKCDSIKAEMVGKLLGHRMRHAER 487 uncultured Planctomycetales bac...
WP_020593376 437 QCVMTIIRDDSYKYVHFtalpPLLFDLKKDPEESLDLAKDPEHFEVVLRYAQKMLSWRQNYAAR 500 Kiloniella laminariae
XP_005973820 427 QCSYAVVRDRHYKYVHFaalpPLLFDLAQDPHEMTNLADRPEMAPIVLRYAQKMLDWRLTHAER 490 chiru
KGD49649     438 GCRCFMAFDGRWKYIHYdgfrPQLFDLSNDPDELVDLGGDAAHAPVRARMHERLFDWLRHRTLR 501 Burkholderia pseudomallei
NP_251023    444 ACRMYMVRSERWKYIAYdgfrAQLFDLASDPGELRDLGADPAHAAVREAHAGMLFDWLRGLKRR 507 Pseudomonas aeruginosa PAO1
EBA02400     430 DARLVMVFDGRWKYVHVeqmrPMLFDLKTDPDELHDLGDNAEHQDQIERLSELHFEWARKHHTR 493 Rhodobacteraceae bacterium HTCC...
WP_019306843 436 DCRAHMIRTKDWKYILHekfsPQLFDLKNDPEEFYDLGADPEYQAVGKKMHEQLFTWFRERLIR 499 SAR324 cluster bacterium SCGC A...
WP_028820971 433 ECSGWMLRNQNWKYIEWqgfrPQLFNLTEDPEEFSDLGEDPGYAQIRSSLKSELMTWMKGINSR 496 beta proteobacterium SCGC AAA02...

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