1BOB


Conserved Protein Domain Family
Hat1_N
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pfam10394: Hat1_N 
Histone acetyl transferase HAT1 N-terminus
This domain is the N-terminal half of the structure of histone acetyl transferase HAT1. It is often found in association with the C-terminal part of the GNAT Acetyltransf_1 (pfam00583) domain. It seems to be motifs C and D of the structure. Histone acetyltransferases (HATs) catalyze the transfer of an acetyl group from acetyl-CoA to the lysine E-amino groups on the N-terminal tails of histones. HATs are involved in transcription since histones tend to be hyper-acetylated in actively transcribed regions of chromatin, whereas in transcriptionally silent regions histones are hypo-acetylated.
Links
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Statistics
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PSSM-Id: 463071
Aligned: 161 rows
Threshold Bit Score: 73.3476
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1BOB_A        11 WTSSANEALRVSIVGEN-AVQ------FSPLFTYPIYGDSEKIYGYKDLIIHLAFDSVTFKPYVNVKYSAklgd-dnivD 82  baker's yeast
XP_009416466  27 TGVEASECIKVFLVKSGdEVGstnsfcINPVDLNQFFGEDGKIYGYKGLRVNIWLSTVSFHAYSEITFEStsdggkgitD 106
XP_002866164  28 TGVEANECIKIYLVSSKeEVDspdiscVKPVDLNDFFDGDGKIYGYQGLKINVWINSISLHSYADITYQSttngdkgitD 107
XP_006367962  28 AGIEANDCITIYIVSSAeDVDspssfcLEPIDLNQFFEDDGRIFGYQGLKITIWVSLISFHAYADISFESssdggrgitN 107
XP_002514170  28 SGIEANECITIYMVSSReQVGasdsfcISPVDLNGFFDEAGKIYGYQGLKITIWISSLTFHAYADITYEStsdggkgitD 107
XP_002282931  27 TGVEAKDCIKIFLVSRKdEVGasdsfcIDPVDLNSFFEEDGKIYGYQGLKITVWINSISFHSYANITFQStsdggkgitD 106
KRH73079      28 SGVEAKDCITIYLVSSKeEFDapesfvIHPVDLNSFFDDDGKIYGYEGLKITIWISSISFYAYADITFQSssdrgkgvtD 107
Q8LPU4        30 AGVEANECMKVFLVWNPgEVSsvdctaIQPFDLNHFFGEDGKIYGYKNLKINVWISAKSFHGYADVSFDEtsdggkgitD 109 Zea mays
Q6ES10        27 AGVEANECMKVFIARNPdEAGsanstsLQPFDLNHFFGEDGKIYGYKNLKINVWISAISFHAYADISFEEtsdggkgitD 106 Japanese rice
XP_003578012  29 AGIEANECMKVFLARNPdDVCsvnntsIEPFDLNHFFGEDGKIYGYTNLKINVWISAISFHAYAEISFQEtsdggkgitD 108

1BOB_A        83 VEKKLLSFLPKddviVRDEAKWVDCFaeERK-THNLSdvFEKVSEYslNGEE---------------FVVYKSSLVDDFA 146 baker's yeast
XP_009416466 107 LEPALQDIFGEl--lTE-KEQFLQTFstERNfIRNIVsdGAVVPCK--TSKEddhasnsnseadgsmIEVIRMKQDSEPV 181
XP_002866164 108 LKSALQNIFAEt--iVDNKDEFLQTFstQSDfIRNMVsnGEVMRSG--ATDGssnnae----vvpsdLQVIRMEIGSPNA 179
XP_006367962 108 VKYALQNIFAEs--lVDEKDAFLQTFstESHyVRSVVsnAETLQHK--VSNGcstesncllksepsdVEVFR--IAGTPV 181
XP_002514170 108 LKNALQRIFAEt--lVENKDDFLRSFsaESHlIRSIVstGEIFHHK--ASNGyigeshl--geptsdMKVFRMAIGNTGA 181
XP_002282931 107 LKSALQTIFAEt--lVETKDDFLQTFstERHyIRSMVsnGEILQHK--ASIGhssnsg---raedsdLEVIRMVMGNMAA 179
KRH73079     108 LKSALQTIFAEt--lVDSKDEFLQKYlaDNDfVRTNIsnGETLKHK--AFKEnicdsnqltdsststVEVVRLVAGNMAT 183
Q8LPU4       110 LKPVLQNIFGEn--lVE-KEEFLHTFskECEyIRTAVtnGSAIKHD--GSYEsd-----------paVEIVRVELQGAAA 173 Zea mays
Q6ES10       107 LKPVLQNIFGEn--lVE-KDEFLKTFskECEyLSNVVtdGNVIKHD--ASIDed-----------saVEIVRVELQGAAA 170 Japanese rice
XP_003578012 109 LKPVLQSIFGEn--lVE-KDEFLETFskECQyISDVVtnGNPIKHD--VSDEgd-----------ldVEIVRVELQGAPA 172

1BOB_A       147 RrMHRRVQIFSLLFIE 162 baker's yeast
XP_009416466 182 ClLYSRLVPLVLLLVD 197
XP_002866164 180 GlLYSRLVPLVLLFVD 195
XP_006367962 182 GhLYSRLVPLVLLLVD 197
XP_002514170 182 GhLYSRLIPLVLLLID 197
XP_002282931 180 GhLYSRLIPLVLLLVD 195
KRH73079     184 GqLYSHLIPLTLLLVD 199
Q8LPU4       174 f-LYSRLVPLVLLLVE 188 Zea mays
Q6ES10       171 f-LYCRLVPLILLLVE 185 Japanese rice
XP_003578012 173 f-LYSRLVSLVLLLVE 187
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